Post-LECA Origin and Diversification of an Axonemal Outer Arm Dynein Motor [PDF]
Cytoskeleton (Hoboken)ABSTRACT Dyneins were present in the last eukaryotic common ancestor (LECA) and play key roles in eukaryotic biology. Axonemal dyneins form the inner and outer arms that power ciliary beating, and it has long been recognized that outer arms in some organisms contain two different heavy chain motors, whereas those from other species contain a third unit
King S.
europepmc +2 more sources
LIS1 and NDEL1 Regulate Axonal Trafficking of Mitochondria in Mature Neurons
Frontiers in Molecular Neuroscience, 2022 Defective mitochondrial dynamics in axons have been linked to both developmental and late-onset neurological disorders. Axonal trafficking is in large part governed by the microtubule motors kinesin-1 and cytoplasmic dynein 1 (dynein).
Jai P. Pandey +3 more
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The retrograde IFT machinery of C. elegans cilia: two IFT dynein complexes? [PDF]
PLoS ONE, 2011 We analyzed the relatively poorly understood IFT-dynein (class DYNC2)-driven retrograde IFT pathway in C. elegans cilia, which yielded results that are surprising in the context of current models of IFT. Assays of C.
Limin Hao +3 more
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Neurodegenerative Mutation in Cytoplasmic Dynein Alters Its Organization and Dynein-Dynactin and Dynein-Kinesin Interactions [PDF]
Journal of Biological Chemistry, 2010 A single amino acid change, F580Y (Legs at odd angles (Loa), Dync1h1(Loa)), in the highly conserved and overlapping homodimerization, intermediate chain, and light intermediate chain binding domain of the cytoplasmic dynein heavy chain can cause severe motor and sensory neuron loss in mice.
Deng, Wenhan +7 more
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Cortical dynein pulling mechanism is regulated by differentially targeted attachment molecule Num1
eLife, 2018 Cortical dynein generates pulling forces via microtubule (MT) end capture-shrinkage and lateral MT sliding mechanisms. In Saccharomyces cerevisiae, the dynein attachment molecule Num1 interacts with endoplasmic reticulum (ER) and mitochondria to ...
Safia Omer +2 more
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Dynein promotes sustained axonal growth and Schwann cell remodeling early during peripheral nerve regeneration. [PDF]
PLoS Genetics, 2019 Following injury, axons of the peripheral nervous system have retained the capacity for regeneration. While it is well established that injury signals require molecular motors for their transport from the injury site to the nucleus, whether kinesin and ...
Melissa Ducommun Priest +3 more
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Lissencephaly-1 is a context-dependent regulator of the human dynein complex
eLife, 2017 The cytoplasmic dynein-1 (dynein) motor plays a central role in microtubule organisation and cargo transport. These functions are spatially regulated by association of dynein and its accessory complex dynactin with dynamic microtubule plus ends. Here, we
Janina Baumbach +6 more
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Dynein-2 intermediate chains play crucial but distinct roles in primary cilia formation and function
eLife, 2018 The dynein-2 microtubule motor is the retrograde motor for intraflagellar transport. Mutations in dynein-2 components cause skeletal ciliopathies, notably Jeune syndrome. Dynein-2 contains a heterodimer of two non-identical intermediate chains, WDR34 and
Laura Vuolo +3 more
doaj +1 more source
Versatile properties of dynein molecules underlying regulation in flagellar oscillation
Scientific Reports, 2023 Dynein is a minus-end-directed motor that generates oscillatory motion in eukaryotic flagella. Cyclic beating, which is the most significant feature of a flagellum, occurs by sliding spatiotemporal regulation by dynein along microtubules.
Takashi Fujiwara +2 more
doaj +1 more source
Regulation of in vivo dynein force production by CDK5 and 14-3-3ε and KIAA0528
Nature Communications, 2019 Dynein plays roles in vesicular, organelle, chromosomal and nuclear transport but so far it is unclear how dynein activity in cells is regulated. Here authors study several dynein cofactors and their role in force adaptation of dynein during lipid ...
Dail E. Chapman +9 more
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