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Cytoplasmic dynein nomenclature [PDF]
The Journal of Cell Biology, 2005 A variety of names has been used in the literature for the subunits of cytoplasmic dynein complexes. Thus, there is a strong need for a more definitive consensus statement on nomenclature. This is especially important for mammalian cytoplasmic dyneins, many subunits of which are encoded by multiple genes.
Pfister, K. Kevin +11 more
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Dynein modifiers in C. elegans: light chains suppress conditional heavy chain mutants. [PDF]
PLoS Genetics, 2007 Cytoplasmic dynein is a microtubule-dependent motor protein that functions in mitotic cells during centrosome separation, metaphase chromosome congression, anaphase spindle elongation, and chromosome segregation. Dynein is also utilized during interphase
Sean M O'Rourke +3 more
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Dynein at the nuclear envelope [PDF]
EMBO reports, 2010 Most cellular organelles are positioned through active transport by motor proteins. The authors discuss the evidence that dynein has important cell cycle‐regulated functions in this context at the nuclear envelope.
René H. Medema +2 more
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A single protofilament is sufficient to support unidirectional walking of dynein and kinesin. [PDF]
PLoS ONE, 2012 Cytoplasmic dynein and kinesin are two-headed microtubule motor proteins that move in opposite directions on microtubules. It is known that kinesin steps by a 'hand-over-hand' mechanism, but it is unclear by which mechanism dynein steps.
Keitaro Shibata +6 more
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Dynein Swings into Action [PDF]
Cell, 2009 Motor proteins, such as dynein, use chemical energy from ATP hydrolysis to move along the cytoskeleton. Roberts et al. (2009) now describe the arrangement of subdomains in the motor domain of dynein and propose a model for how these regions function together in force generation.
Anne Houdusse +2 more
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Post-LECA Origin and Diversification of an Axonemal Outer Arm Dynein Motor [PDF]
Cytoskeleton (Hoboken)ABSTRACT Dyneins were present in the last eukaryotic common ancestor (LECA) and play key roles in eukaryotic biology. Axonemal dyneins form the inner and outer arms that power ciliary beating, and it has long been recognized that outer arms in some organisms contain two different heavy chain motors, whereas those from other species contain a third unit
King S.
europepmc +2 more sources
Dynein and intraflagellar transport [PDF]
Experimental Cell Research, 2015 Publisher Summary This chapter provides a brief background on intraflagellar transport (IFT) and reviews the studies culminating in the identification of the dynein motor that powers retrograde IFT. IFT is the active movement of multi-subunit particles along axonemal doublet microtubules in the space between the outer-doublet microtubules and the ...
Hou, Yuqing, Witman, George B.
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Dynein light intermediate chains as pivotal determinants of dynein multifunctionality [PDF]
Journal of Cell Science, 2021 ABSTRACT In animal cells, a single cytoplasmic dynein motor mediates microtubule minus-end-directed transport, counterbalancing dozens of plus-end-directed kinesins. The remarkable ability of dynein to interact with a diverse cargo spectrum stems from its tightly regulated recruitment of cargo-specific adaptor proteins, which engage the ...
Amrita Kumari +3 more
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Dynein-Dependent Endo-Lysosomal Degradation Drives Lewy Body Disorders Accompanied by Aβ Pathology. [PDF]
Adv Sci (Weinh)This study investigates the impact of Aβ plaques on α‐synuclein (αSyn) pathologies in dementia with Lewy bodies (DLB). Co‐culturing primary neurons with AD mouse brain slices reveals impaired dynein‐dependent organelle trafficking, affecting αSyn degradation. Activating Rab7 restores this process, reducing αSyn inclusions.
Zhou L +14 more
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Lis1 activates dynein motility by modulating its pairing with dynactin
Nature Cell Biology, 2020 Lissencephaly-1 (Lis1) is a key cofactor for dynein-mediated intracellular transport towards the minus-ends of microtubules. It remains unclear whether Lis1 serves as an inhibitor or an activator of mammalian dynein motility.
M. M. ElShenawy +5 more
semanticscholar +1 more source