Results 31 to 40 of about 43,287 (283)
Lis1 promotes the formation of activated cytoplasmic dynein-1 complexes
Nature Cell Biology, 2020 Cytoplasmic dynein-1 is a molecular motor that drives nearly all minus-end-directed microtubule-based transport in human cells, performing functions that range from retrograde axonal transport to mitotic spindle assembly 1 , 2 .
Z. Htet +5 more
semanticscholar +1 more source
Dynein and dynein-related genes [PDF]
Cell Motility and the Cytoskeleton, 1998 Dyneins are large, multisubunit ATPases that interact with microtubules to generate force. Dyneins move eukaryotic cilia and flagella and are in the cytoplasm, where they are involved in the transport of particles and organelles along microtubules and in the transport of condensed chromosomes during mitosis [reviewed in Holzbaur et al., 1994; Gibbons ...
openaire +2 more sources
Biology Open, 2021 Ciliary motility is powered by a suite of highly conserved axoneme-specific dynein motor complexes. In humans, the impairment of these motors through mutation results in the disease primary ciliary dyskinesia (PCD).
Petra zur Lage +7 more
doaj +1 more source
Sequential dynein effectors regulate axonal autophagosome motility in a maturation-dependent pathway
bioRxiv, 2020 Autophagy is a degradative pathway required to maintain neuronal homeostasis. Neuronal autophagosomes form constitutively at the axon terminal and mature via lysosomal fusion during dynein-mediated transport to the soma.
Sydney E. Cason +5 more
semanticscholar +1 more source
Structural basis for cytoplasmic dynein-1 regulation by Lis1
eLife, 2022 The lissencephaly 1 gene, LIS1, is mutated in patients with the neurodevelopmental disease lissencephaly. The Lis1 protein is conserved from fungi to mammals and is a key regulator of cytoplasmic dynein-1, the major minus-end-directed microtubule motor ...
John P Gillies +6 more
doaj +1 more source
Cell cycle-dependent microtubule-based dynamic transport of cytoplasmic dynein in mammalian cells. [PDF]
PLoS ONE, 2009 BACKGROUND:Cytoplasmic dynein complex is a large multi-subunit microtubule (MT)-associated molecular motor involved in various cellular functions including organelle positioning, vesicle transport and cell division.
Takuya Kobayashi, Takashi Murayama
doaj +1 more source
Nde1 and Ndel1: Outstanding Mysteries in Dynein-Mediated Transport
Frontiers in Cell and Developmental Biology, 2022 Cytoplasmic dynein-1 (dynein) is the primary microtubule minus-end directed molecular motor in most eukaryotes. As such, dynein has a broad array of functions that range from driving retrograde-directed cargo trafficking to forming and focusing the ...
Sharon R. Garrott +4 more
doaj +1 more source
Structures of outer-arm dynein array on microtubule doublet reveal a motor coordination mechanism
Nature Structural & Molecular Biology, 2020 Thousands of outer-arm dyneins (OADs) are arrayed in the axoneme to drive a rhythmic ciliary beat. Coordination among multiple OADs is essential for generating mechanical forces to bend microtubule doublets (MTDs).
Q. Rao +9 more
semanticscholar +1 more source
New insights into the mechanism of dynein motor regulation by lissencephaly-1
eLife, 2020 Lissencephaly (‘smooth brain’) is a severe brain disease associated with numerous symptoms, including cognitive impairment, and shortened lifespan. The main causative gene of this disease – lissencephaly-1 (LIS1) – has been a focus of intense scrutiny ...
S. M. Markus, M. G. Marzo, R. Mckenney
semanticscholar +1 more source
Dynein activators and adaptors at a glance
Journal of Cell Science, 2019 Cytoplasmic dynein-1 (hereafter dynein) is an essential cellular motor that drives the movement of diverse cargos along the microtubule cytoskeleton, including organelles, vesicles and RNAs.
Mara A Olenick, E. Holzbaur
semanticscholar +1 more source