Probing electrophysiological activity of amphiphilic Dynorphin A in planar neutral membranes reveals both ion channel-like activity and neuropeptide translocation [PDF]
Dynorphin A (DynA) is an endogenous neuropeptide that besides acting as a ligand of the κ-opioid receptor, presents some non-opioid pathophysiological properties associated to its ability to induce cell permeability similarly to cell-penetrating peptides
Alcaraz, Antonio+5 more
core +1 more source
Somatostatin: A Novel Substrate and a Modulator of Insulin-Degrading Enzyme Activity [PDF]
Insulin-degrading enzyme (IDE) is an interesting pharmacological target for Alzheimer's disease (AD), since it hydrolyzes beta-amyloid, producing non-neurotoxic fragments.
Ciaccio C+8 more
core +1 more source
Dynorphins are endogenous neuropeptides that function as ligands for the κ-opioid receptor. In addition to opioid activity, dynorphins can induce several pathological effects such as neurological dysfunctions and cell death.
D. Aurora Perini+4 more
doaj
Background Microglia-mediated neuroinflammation is associated with epilepsy. Switching microglial polarization from the pro-inflammatory M1 phenotype to the anti-inflammatory M2 phenotype represents a novel therapeutic strategy for mitigating ...
Lin Liu+5 more
doaj +1 more source
Dopamine-D1 and δ-opioid receptors co-exist in rat striatal neurons [PDF]
Cocaine’s enhancement of dopaminergic neurotransmission in the mesolimbic pathway plays a critical role in the initial reinforcing properties of this drug. However, other neurotransmitter systems are also integral to the addiction process.
Ambrose-Lanci, L. M.+3 more
core +2 more sources
Pain 87 (2000) 235-239. doi:10.1016/S0304-3959(00)00360-2 ; Received by publisher: 2000-05-22 ; Harvest Date: 2016-01-04 12:22:07 ; DOI:10.1016/S0304-3959(00)00360-2 ; Page Range: 235 ...
Department of Oral Surgery, Division of Neuroscience, University of Florida College of Dentistry, P.O. Box 100416, Gainesville, FL 32610, USA ( host institution )+2 more
openaire +4 more sources
Immunoreactive dynorphin in pituitary and brain. [PDF]
Distribution of the potent opioid peptide dynorphin has been determined in pituitary gland (pig, beef, rat), in the various regions of rat brain, and in rat spinal cord, by using a highly specific antiserum. By gel permeation chromatography in 4 M guanidine, the porcine pituitary immunoreactivity is found in a major peak of apparent molecular weight ...
Avram Goldstein, Vartan E. Ghazarossian
openaire +3 more sources
Concomitant duplications of opioid peptide and receptor genes before the origin of jawed vertebrates. [PDF]
BACKGROUND: The opioid system is involved in reward and pain mechanisms and consists in mammals of four receptors and several peptides. The peptides are derived from four prepropeptide genes, PENK, PDYN, PNOC and POMC, encoding enkephalins, dynorphins ...
Görel Sundström+2 more
doaj +1 more source
Opioid modulation of GABA release in the rat inferior colliculus [PDF]
Background: The inferior colliculus, which receives almost all ascending and descending auditory signals, plays a crucial role in the processing of auditory information.
Casalotti, SO+7 more
core +3 more sources
Characterization of kappa opioid receptor mediated, dynorphin-stimulated [35S]GTPγS binding in mouse striatum for the evaluation of selective KOR ligands in an endogenous setting [PDF]
Differential modulation of kappa opioid receptor (KOR) signaling has been a proposed strategy for developing therapies for drug addiction and depression by either activating or blocking this receptor.
Aubé, Jeffrey+6 more
core +1 more source