Results 31 to 40 of about 10,432 (275)

Probing electrophysiological activity of amphiphilic Dynorphin A in planar neutral membranes reveals both ion channel-like activity and neuropeptide translocation [PDF]

open access: yes, 2023
Dynorphin A (DynA) is an endogenous neuropeptide that besides acting as a ligand of the κ-opioid receptor, presents some non-opioid pathophysiological properties associated to its ability to induce cell permeability similarly to cell-penetrating peptides
Alcaraz, Antonio   +5 more
core   +1 more source

Somatostatin: A Novel Substrate and a Modulator of Insulin-Degrading Enzyme Activity [PDF]

open access: yes, 2009
Insulin-degrading enzyme (IDE) is an interesting pharmacological target for Alzheimer's disease (AD), since it hydrolyzes beta-amyloid, producing non-neurotoxic fragments.
Ciaccio C   +8 more
core   +1 more source

Dynorphin A induces membrane permeabilization by formation of proteolipidic pores. Insights from electrophysiology and computational simulations

open access: yesComputational and Structural Biotechnology Journal, 2022
Dynorphins are endogenous neuropeptides that function as ligands for the κ-opioid receptor. In addition to opioid activity, dynorphins can induce several pathological effects such as neurological dysfunctions and cell death.
D. Aurora Perini   +4 more
doaj  

Dynorphin activation of kappa opioid receptor promotes microglial polarization toward M2 phenotype via TLR4/NF-κB pathway

open access: yesCell & Bioscience, 2020
Background Microglia-mediated neuroinflammation is associated with epilepsy. Switching microglial polarization from the pro-inflammatory M1 phenotype to the anti-inflammatory M2 phenotype represents a novel therapeutic strategy for mitigating ...
Lin Liu   +5 more
doaj   +1 more source

Dopamine-D1 and δ-opioid receptors co-exist in rat striatal neurons [PDF]

open access: yes, 2006
Cocaine’s enhancement of dopaminergic neurotransmission in the mesolimbic pathway plays a critical role in the initial reinforcing properties of this drug. However, other neurotransmitter systems are also integral to the addiction process.
Ambrose-Lanci, L. M.   +3 more
core   +2 more sources

Dynorphin: friend or foe?

open access: yesPain, 2000
Pain 87 (2000) 235-239. doi:10.1016/S0304-3959(00)00360-2 ; Received by publisher: 2000-05-22 ; Harvest Date: 2016-01-04 12:22:07 ; DOI:10.1016/S0304-3959(00)00360-2 ; Page Range: 235 ...
Department of Oral Surgery, Division of Neuroscience, University of Florida College of Dentistry, P.O. Box 100416, Gainesville, FL 32610, USA ( host institution )   +2 more
openaire   +4 more sources

Immunoreactive dynorphin in pituitary and brain. [PDF]

open access: yesProceedings of the National Academy of Sciences, 1980
Distribution of the potent opioid peptide dynorphin has been determined in pituitary gland (pig, beef, rat), in the various regions of rat brain, and in rat spinal cord, by using a highly specific antiserum. By gel permeation chromatography in 4 M guanidine, the porcine pituitary immunoreactivity is found in a major peak of apparent molecular weight ...
Avram Goldstein, Vartan E. Ghazarossian
openaire   +3 more sources

Concomitant duplications of opioid peptide and receptor genes before the origin of jawed vertebrates. [PDF]

open access: yesPLoS ONE, 2010
BACKGROUND: The opioid system is involved in reward and pain mechanisms and consists in mammals of four receptors and several peptides. The peptides are derived from four prepropeptide genes, PENK, PDYN, PNOC and POMC, encoding enkephalins, dynorphins ...
Görel Sundström   +2 more
doaj   +1 more source

Opioid modulation of GABA release in the rat inferior colliculus [PDF]

open access: yes, 2004
Background: The inferior colliculus, which receives almost all ascending and descending auditory signals, plays a crucial role in the processing of auditory information.
Casalotti, SO   +7 more
core   +3 more sources

Characterization of kappa opioid receptor mediated, dynorphin-stimulated [35S]GTPγS binding in mouse striatum for the evaluation of selective KOR ligands in an endogenous setting [PDF]

open access: yes, 2015
Differential modulation of kappa opioid receptor (KOR) signaling has been a proposed strategy for developing therapies for drug addiction and depression by either activating or blocking this receptor.
Aubé, Jeffrey   +6 more
core   +1 more source

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