Results 41 to 50 of about 10,432 (275)
Frontiers in Pharmacology, 2015 Salvinorin A is a potent hallucinogen, isolated from the ethnomedical plant Salvia divinorum. Salvinorin A is a selective high efficacy kappa-opioid receptor (KOPr) agonist, and thus implicates the KOPr system and its endogenous agonist ligands (the ...
Eduardo eButelman, Mary Jeanne eKreek
doaj +1 more source
Interactions of the opioid and cannabinoid systems in reward: Insights from knockout studies
Frontiers in Pharmacology, 2015 The opioid system consists of three receptors, mu, delta, and kappa, which are activated by endogenous opioid peptides (enkephalins, endorphins and dynorphins). The endogenous cannabinoid system comprises lipid neuromodulators (endocannabinoids), enzymes
Katia eBefort
doaj +1 more source
Identification of Dynorphins as Endogenous Ligands for an Opioid Receptor-like Orphan Receptor (*)
Journal of Biological Chemistry, 1995 To identify the endogenous ligands for a cloned orphan receptor that shares high degrees of sequence homology with opioid receptors, this orphan receptor was expressed in Xenopus oocytes and in mammalian cell lines CHO-K1 and HEK-293. The coupling of the
Shengwen Zhang, Lei Yu
semanticscholar +1 more source
Virus-mediated shRNA knockdown of prodynorphin in the rat nucleus accumbens attenuates depression-like behavior and cocaine locomotor sensitization. [PDF]
PLoS ONE, 2014 Dynorphins, endogenous opioid peptides that arise from the precursor protein prodynorphin (Pdyn), are hypothesized to be involved in the regulation of mood states and the neuroplasticity associated with addiction.
Ami Cohen +7 more
doaj +1 more source
Efeito da eletro-acupuntura na prevenção da catarata induzida por selenito de sódio em ratos Wistar [PDF]
, 2006 PURPOSE: To investigate whether electroacupuncture can prevent selenite-induced cataract in an experimental model. METHODS: Fifty Wistar rat pups were randomized into 5 groups of 10 animals: Group 1 (control), no procedure was performed; Group 2 ...
Cariello, Angelino Julio +4 more
core +2 more sources
Peptide ligand recognition by G protein-coupled receptors [PDF]
, 2015 Introduction: This study was conducted to investigate the effects of thyme extract in drinking water on immune response of broiler chickens. Methods: A total of 245-day-old broiler chicks were purchased and 20 chicks were bled for determination maternal ...
Brian E. Krumm, Reinhard Grisshammer
core +4 more sources
Frontiers in Behavioral Neuroscience, 2015 Whether the opioid system plays a role in the ability to flexibly adapt behavior is still unclear. We used fMRI to investigate the effect of a nucleotide tandem repeat (68-bp VNTR) functional polymorphism of the prodynorphin gene on cerebral activation ...
Mikhail eVotinov +7 more
doaj +1 more source
Contralateral inhibition of click- and chirp-evoked human compound action potentials [PDF]
, 2017 Cochlear outer hair cells (OHC) receive direct efferent feedback from the caudal auditory brainstem via the medial olivocochlear (MOC) bundle. This circuit provides the neural substrate for the MOC reflex, which inhibits cochlear amplifier gain and is ...
Cone, Barbara K +2 more
core +2 more sources
Dynorphin‐based “release on demand” gene therapy for drug‐resistant temporal lobe epilepsy
EMBO Molecular Medicine, 2019 Focal epilepsy represents one of the most common chronic CNS diseases. The high incidence of drug resistance, devastating comorbidities, and insufficient responsiveness to surgery pose unmet medical challenges.
Alexandra S Agostinho +10 more
doaj +1 more source
Oligodendrogenesis in Evolution, Development and Adulthood
Glia, EarlyView.Oligodendrocytes and myelin took shape in jawed vertebrates. During development, OPCs are originated from NSCs and then undergo differentiation into mature oligodendrocytes that supply myelin. OPCs persist in the adult CNS and continue to produce oligodendrocytes and myelin. Adaptive myelination, which fine‐tunes neural circuits in response to neuronal
Hao Hu +3 more
wiley +1 more source