Efeito da eletro-acupuntura na prevenção da catarata induzida por selenito de sódio em ratos Wistar [PDF]
, 2006 PURPOSE: To investigate whether electroacupuncture can prevent selenite-induced cataract in an experimental model. METHODS: Fifty Wistar rat pups were randomized into 5 groups of 10 animals: Group 1 (control), no procedure was performed; Group 2 ...
Cariello, Angelino Julio +4 more
core +2 more sources
The Pathophysiologic Mechanism of Tinnitus [PDF]
, 2016 Tinnitus represents a phantom auditory sensation without an external sound source. The reported prevalence of tinnitus estimates 15-20% in world population.
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Dynorphin‐based “release on demand” gene therapy for drug‐resistant temporal lobe epilepsy
EMBO Molecular Medicine, 2019 Focal epilepsy represents one of the most common chronic CNS diseases. The high incidence of drug resistance, devastating comorbidities, and insufficient responsiveness to surgery pose unmet medical challenges.
Alexandra S Agostinho +10 more
doaj +1 more source
Afferent Neuronal Control of Type-I Gonadotropin Releasing Hormone Neurons in the Human. [PDF]
, 2013 Understanding the regulation of the human menstrual cycle represents an important ultimate challenge of reproductive neuroendocrine research. However, direct translation of information from laboratory animal experiments to the human is often complicated ...
Hrabovszky, Erik, Liposits, Zsolt
core +1 more source
Proteasome targeted therapy in arthritis models -effects on pain and inflammation [PDF]
, 2010 The ubiquitin proteasome system (UPS) regulates numerous cellular functions by selectively degrading cellular proteins. It controls activation of the transcription factor NF-ĸB which is involved in the expression of pro-inflammatory mediators.
Ahmed, Aisha Siddiqah
core
Acute cocaine treatment increases thimet oligopeptidase in the striatum of rat brain [PDF]
, 2012 Many studies indicate that thimet oligopeptidase (EC3.4.24.15; TOP) can be implicated in the metabolism of bioactive peptides, including dynorphin 1-8, alpha-neoendorphin, beta-neoendorphin and GnRH.
Andersen, Monica Levy +13 more
core +1 more source
Des-tyrosine-dynorphin antagonizes morphine analgesia [PDF]
European Journal of Pharmacology, 1982 Peer Reviewed ; http://deepblue.lib.umich.edu/bitstream/2027.42/23809/1/0000047 ...
Walker, J. Michael +4 more
openaire +3 more sources
Fetal Pain Perception: Legislative Assertions and Developmental Neuroscience
Annals of the Child Neurology Society, EarlyView.ABSTRACT Background Pain perception is a conscious experience, but neither pain nor consciousness is defined in the developing human fetus. Emergent consciousness may be regarded as a phenomenon that ultimately arises from an essential minimum of functional neuronal connectivity. Proposed U.S.
William D. Graf +9 more
wiley +1 more source
Nicotine Effects and the Endogenous Opioid System
Journal of Pharmacological Sciences, 2014 .: Nicotine (NIC) is an exogenous ligand of the nicotinic acetylcholine receptor (nAChR), and it influences various functions in the central nervous system. Systemic administration of NIC elicits the release of endogenous opioids (endorphins, enkephalins,
Shiroh Kishioka +3 more
doaj +1 more source
Evaluation of Potential Hormonal Activities of Ashwagandha (Withania somnifera)
Phytotherapy Research, EarlyView.ABSTRACT Ashwagandha is a widely used herb in traditional medicine systems, particularly Ayurveda. Despite its extensive tradition, growing concerns regarding its potential endocrinological effects have prompted scientific scrutiny. This review systematically evaluates the current preclinical, clinical, and case study evidence concerning AS's effects ...
Günter Vollmer, Thomas Brendler
wiley +1 more source