Results 51 to 60 of about 10,432 (275)

Capillary HPLC Separation of Selected Neuropeptides [PDF]

, 2012
Neuropeptides play a pivotal role in brain and peripheral nervous system function. As high performance liquid chromatography (HPLC) becomes the central tool in the separation and characterization of peptide and protein samples, its selectivity ...
Yi, Ying
core  

Perivascular Expression and Potent Vasoconstrictor Effect of Dynorphin A in Cerebral Arteries [PDF]

, 2012
BACKGROUND: Numerous literary data indicate that dynorphin A (DYN-A) has a significant impact on cerebral circulation, especially under pathophysiological conditions, but its potential direct influence on the tone of cerebral vessels is obscure.
A Ouyang, A Thureson-Klein, A Venteicher, AI Faden, AI Faden, AI Faden, AI Faden, AI Faden, AI Faden, AI Faden, AI Faden, Attila Cselenyák, B Brugos, B Horváth, BT Altura, BT Altura, C Severi, CR Figley, CS Roy, D Massardier, E Hamel, EA Young, H Tada, J Hu, J Lai, JE Hardebo, JF Tong, JM Quillan, JO Devine, JP Headrick, JP Headrick, JR Grider, JY Kong, Ken Arai, Krisztina Káldi, L Zhang, M Deli, M Miura, MA Moskowitz, MA Moskowitz, MC Thorogood, P Sándor, Péter Sándor, R Uddman, Rege Sugárka Papp, RL Klein, RM Arendt, RM Caudle, RM Caudle, S Müller, S Müller, S Zhang, SA Krumins, SE Kapadia, SJ Evans, T Willis, Tamás Németh, TJ Schwedt, TK Mcintosh, V Shankar, VM Pickel, WM Armstead, WM Armstead, WM Armstead, WM Armstead, WM Armstead, WM Armstead, WM Armstead, WM Armstead, Z Benyó, Z Benyó, Z Lacza, Zoltán Benyó, Éva Ruisanchez   +73 more
core   +4 more sources

Physiologically Based Pharmacokinetic (PBPK) Model to Predict the Magnitude of Drug–Drug Interaction Between Fezolinetant and CYP1A2 Inhibitors

The Journal of Clinical Pharmacology, EarlyView.
Abstract Fezolinetant is a non‐hormonal, selective neurokinin 3 receptor antagonist approved in multiple countries including the United States, in Europe, and in Asia for the treatment of moderate to severe vasomotor symptoms in menopausal women. Fezolinetant is primarily metabolized by CYP1A2 and was found to be a sensitive substrate for CYP1A2 ...
Mary P. Choules, Yukio Otsuka, Jace C. Nielsen, Megumi Iwai, Peter L. Bonate   +4 more
wiley   +1 more source

Proteasome targeted therapy in arthritis models -effects on pain and inflammation [PDF]

, 2010
The ubiquitin proteasome system (UPS) regulates numerous cellular functions by selectively degrading cellular proteins. It controls activation of the transcription factor NF-ĸB which is involved in the expression of pro-inflammatory mediators.
Ahmed, Aisha Siddiqah
core  

Determination of Dynorphins And Tnf- A By Lc-ms/ms In Biological Samples: Applicable To Studying Inflammatory Mechanisms [PDF]

, 2020
Dynorphins are endogenous opioid peptides that have been implicated as initiators ofimmune and inflammatory response through upregulation ofinflammatory cytokine and chemokine production, as well having a role in glutamate-induced neuro-inflammation and ...
Chandu, Karthik
core   +1 more source

The endogenous opioid dynorphin is required for normal bone homeostasis in mice [PDF]

, 2012
International ...
Baldock, PA, Castillo, L, Driessler, F, Eisman, J, Enriquez, RF, Herzog, H, Janmaat, S, Kieffer, B, Lin, S, Sainsbury, Amanda, Schwarzer, C, Shi, YC, Wong, IPL, Yulyaningsih, E, Zengin, A   +14 more
core   +2 more sources

Mechanism and site of action of big dynorphin on ASIC1a [PDF]

Proceedings of the National Academy of Sciences, 2019
Acid-sensing ion channels (ASICs) are proton-gated cation channels that contribute to neurotransmission, as well as initiation of pain and neuronal death following ischemic stroke. As such, there is a great interest in understanding the in vivo regulation of ASICs, especially by endogenous neuropeptides that potently modulate ASICs.
Borg, Christian B., Braun, Nina, Heusser, Stephanie A., Bay, Yasmin, Weis, Daniel, Galleano, Iacopo, Lund, Camilla, Tian, Weihua, Haugaard-Kedström, Linda M., Bennett, Eric P., Lynagh, Timothy, Strømgaard, Kristian, Andersen, Jacob, Pless, Stephan A.   +13 more
openaire   +7 more sources

Photoaffinity labeling coupled to MS to identify peptide biological partners: Secondary reactions, for better or for worse?

Mass Spectrometry Reviews, EarlyView.
Abstract Affinity photolabeling is a smart method to study noncovalent and transient interactions and provide a submolecular picture of the contacts between interacting partners. In this review, we will focus on the identification of peptide partners using photoaffinity labeling coupled to mass spectrometry in different contexts such as in vitro with a
Astrid Walrant, Emmanuelle Sachon
wiley   +1 more source

Variabilidad de los genes pdyn y oprk1 en cuatro poblaciones argentinas y su asociación con variables clínicas relacionadas al dolor agudo post-quirúrgico [PDF]

, 2022
Several population studies showed an association between variation in pain sensitivity and genetic polymorphisms located in Prodynorphin (PDYN) and Kappa Opioid Receptor (OPRK1) human genes.
Catanesi, Cecilia Ines, Di Santo Meztler, Gabriela Paula, Esteban Torné, M. Esther, Martina, Pablo F., Rigalli, Alfredo, Schiaffi, Jorge Alfredo   +5 more
core   +2 more sources

Kisspeptin as a test of hypothalamic dysfunction in pubertal and reproductive disorders

Andrology, EarlyView.
Abstract The hypothalamic–pituitary–gonadal axis is regulated by the gonadotropin‐releasing hormone pulse generator in the hypothalamus. This is comprised of neurons that secrete kisspeptin in a pulsatile manner to stimulate the release of GnRH, and, in turn, downstream gonadotropins from the pituitary gland, and subsequently sex steroids and ...
Aureliane C. S. Pierret, Aaran H. Patel, Elisabeth Daniels, Alexander N. Comninos, Waljit S. Dhillo, Ali Abbara   +5 more
wiley   +1 more source