Results 61 to 70 of about 5,930 (239)

Membrane leakage induced by dynorphins

FEBS Letters, 2006
Dynorphins, endogeneous opioid peptides, function as ligands to the opioid kappa receptors and induce non‐opioid excitotoxic effects. Here we show that big dynorphin and dynorphin A, but not dynorphin B, cause leakage effects in large unilamellar phospholipid vesicles (LUVs).
Hugonin, Loïc, Vukojević, Vladana, Bakalkin, Georgy, Gräslund, Astrid   +3 more
openaire   +2 more sources

Chronic pain recruits hypothalamic dynorphin/kappa opioid receptor signalling to promote wakefulness and vigilance [PDF]

, 2022
Hisakatsu Ito, Edita Navratilova, Barbora Vagnerova, Moe Watanabe, Carol Kopruszinski, Luiz Henrique Moreira de Souza, Xu Yue, Daigo Ikegami, Aubin Moutal, Amol Patwardhan, Rajesh Khanna, Mitsuaki Yamazaki, Miguel Guerrero, Hugh Rosen, Ed Roberts, Volker Neugebauer, David W. Dodick, Frank Porreca   +17 more
openalex   +1 more source

Epigenetic mechanisms and therapeutic innovations in chronic pain‐associated neuropsychiatric co‐morbidities

British Journal of Pharmacology, EarlyView.
Abstract Chronic pain, marked by nociceptive sensitization and maladaptive neuroplasticity, affects 30% of the global population with escalating socioeconomic burdens. Epidemiological data show a 2‐3‐fold increase in neuropsychiatric co‐morbidities among individuals with chronic pain, where epigenetic dysregulation serves as a key mechanism linking ...
Kai Zhang, Sijia Zhu, Na Xing, Zhen Zhou, Jiayi Chen, Tianen Si, Mingrui Li, Lin Jia, Yousef Rastegar‐Kashkooli, Tom J. Wang, Wei Zhu, Jing Li, Chao Jiang, Junmin Wang, Moxin Wu, Xiaoping Yin, Weidong Zang, Jian Wang, Songxue Su   +18 more
wiley   +1 more source

The Opioid System in Temporal Lobe Epilepsy: Functional Role and Therapeutic Potential

Frontiers in Molecular Neuroscience, 2017
Temporal lobe epilepsy is considered to be one of the most common and severe forms of focal epilepsies. Patients often develop cognitive deficits and emotional blunting along the progression of the disease.
Johannes Burtscher, Christoph Schwarzer
doaj   +1 more source

Synthesis of a novel universal opioid receptor agonist with the 1,3,5-trioxazatriquinane skeleton and its pharmacologies [PDF]

, 2014
We designed and synthesized of 1,3,5-trioxazatriquinanes with o- or p-hydroxyphenyl rings as analogs of the κ opioid receptor agonist SYK-146 with m-hydroxyphenyl groups. Although almost all tested compounds did not bind to the opioid receptors, only 17b
Fujii Hideaki, Hirayama Shigeto, Hirono Shuichi, Iwai Takashi, Kuroda Naoya, Nagase Hiroshi, Wada Naohisa, Yamaotsu Noriyuki, 長瀬 博   +8 more
core   +1 more source

Gene therapy for epilepsy: An emerging, promising approach for a serious neurological disorder

Journal of Internal Medicine, EarlyView.
Abstract Gene therapy is emerging as a groundbreaking strategy for treating epilepsy, offering new hope to patients who do not respond to conventional medications. Despite advancements in anti‐seizure treatments, nearly 30%–40% of individuals with epilepsy continue to experience uncontrolled seizures, highlighting the urgent need for more effective and
Marco Ledri, Merab Kokaia
wiley   +1 more source

Gut-brain axis: Role of lipids in the regulation of inflammation, pain and CNS diseases [PDF]

, 2018
The human gut is a composite anaerobic environment with a large, diverse and dynamic enteric microbiota, represented by more than 100 trillion microorganisms, including at least 1000 distinct species.
Avagliano, Carmen, BERNI CANANI, Roberto, Calignano, Antonio, Cristiano, Claudia, DE CARO, Carmen, LA RANA, Giovanna, MATTACE RASO, Giuseppina, Meli, Rosaria, Russo, Roberto   +8 more
core   +1 more source

Effects of Electroacupuncture at ST36 on Visceral Pain and Inflammatory Markers in IBS Rats

Neurogastroenterology &Motility, EarlyView.
Electroacupuncture (EA) at ST36 significantly reduced visceral pain and colonic inflammation in IBS model rats. EA increased pain thresholds, lowered AWR scores, and downregulated key inflammatory mediators (IL‐1β, IL‐6, TNF‐α, TRPV1, NF‐κB). These findings highlight ST36‐targeted EA as a promising therapeutic strategy for IBS visceral hypersensitivity
Ya‐bo Hao, Yan‐lin Liu, Xiao‐mei Wang, Kai Cheng, Qing‐yu Tu, Fei Dai, Xi‐bing Yang   +6 more
wiley   +1 more source

The effectiveness of aerobic exercise on pain and disability in individuals with neck pain: A systematic review and meta‐analysis

Experimental Physiology, EarlyView.
Abstract The present review aimed to investigate the effectiveness of aerobic exercise (AE) compared to other interventions in decreasing pain intensity and reducing disability in individuals with neck pain. A systematic review (SR) of randomized controlled trials was conducted. This SR was registered in PROSPERO (CRD42021231231).
Ana lzabela Sobral de Oliveira‐Souza, Marie Kempe, Sofia Grimmelsmann, Luiz Felipe Tavares, Ester Moreira De Castro‐Carletti, Angela Viegas Andrade, Liz Dennett, Harry Von Piekartz, Jorge Fuentes Contreras, Susan Armijo‐Olivo   +9 more
wiley   +1 more source

Imaging mass spectrometry reveals elevated nigral levels of dynorphin neuropeptides in L-DOPA-induced dyskinesia in rat model of Parkinson's disease.

PLoS ONE, 2011
L-DOPA-induced dyskinesia is a troublesome complication of L-DOPA pharmacotherapy of Parkinson's disease and has been associated with disturbed brain opioid transmission.
Anna Ljungdahl, Jörg Hanrieder, Maria Fälth, Jonas Bergquist, Malin Andersson   +4 more
doaj   +1 more source