Results 31 to 40 of about 24,019 (278)

α‐Synuclein aggregation landscape from phase separation to neurotoxic intermediates

FEBS Letters, EarlyView.
Alpha‐synuclein aggregation in Parkinson's disease involves a complex landscape of transient intermediates, including oligomers, fibrils and liquid–liquid phase separation (LLPS). A view is emerging in which LLPS maturation into solid‐like condensates may contribute to the formation of neurotoxic species.
Silvia Arino, Giuliana Fusco, Alfonso De Simone   +2 more
wiley   +1 more source

Fatores que influenciam a aprendizagem de conceitos matemáticos em cursos de engenharia: Um estudo exploratório com estudantes da Universidade do Minho

Revista Portuguesa de Educação, 2016
O sucesso na aprendizagem da Matemática no ensino superior constitui um campo emergente de pesquisa, em particular nos cursos de Engenharia. No entanto, em Portugal ainda é incipiente a pesquisa na área, pelo que é pertinente  explorar  fatores  que ...
Manuela Alves, Clara Coutinho, Ana Maria A. C. Rocha, Cristina Rodrigues   +3 more
doaj   +1 more source

Modelling stem cell differentiation related processes—A practical overview for biologists

FEBS Letters, EarlyView.
Stem cell differentiation is complex and difficult to control experimentally. This review introduces suitable computational modelling approaches that can support stem cell research, from mechanistic ODE and abstract models to multiscale and deep learning methods.
Ricco Zeegelaar, Xinqi Yan, Lucas Jansen Klomp, Stefano Schivo, Janine N. Post   +4 more
wiley   +1 more source

Arithmeticae contemplatio subtilissima est: l’enciclopedia matematica di Girolamo Cardano [PDF]

, 2015
L’Ars Magna (1545) di Girolamo Cardano (1501-1576), pietra miliare della storia dell’algebra, è generalmente considerata come un capolavoro pressoché isolato nella produzione matematica del medico milanese, un’opera che giganteggia su un panorama ...
GAVAGNA, Veronica
core  

Possibilidades pedagógicas do uso das tecnologias móveis no ensino de matemática na perspectiva da m-learning

BoEM: Boletim Online de Educação Matemática, 2018
Este trabalho é fruto de uma dissertação do Mestrado Profissional em Ensino de Ciências e Matemática (PPGECIM/UFAL) que busca investigar a utilização de um aplicativo (App) em aulas de Matemática numa Escola Estadual no município de Matriz de Camaragibe,
Carloney Alves de Oliveira, Jenekésia Lins da Silva   +1 more
doaj   +1 more source

Design and analysis strategies for robust microbiome ageing research

FEBS Letters, EarlyView.
The gut microbiome changes with age and associates with age‐related morbidity and mortality, establishing it as a potential biomarker and intervention target for ageing. Realising this potential requires methodological rigour, yet distinguishing biological signals from methodological artefacts remains challenging across cohorts. This review provides an
Mark Olenik, İsmail Güderer, Yi Wang, Tayyaba Alvi, Prasoon Pandey, Handan Melike Dönertaş   +5 more
wiley   +1 more source

Reconstructing enzyme evolution by protein engineering

FEBS Letters, EarlyView.
Natural enzyme evolution can be retraced by protein engineering methods such as directed evolution, rational design, and ancestral sequence reconstruction. These approaches reveal how enzymes emerged from ligand‐binding scaffolds, developed varying substrate preferences, formed oligomeric complexes, adapted to environmental changes, and evolved novel ...
Lukas Drexler, Markus R. Busch, Reinhard Sterner   +2 more
wiley   +1 more source

Rendiconti dell’Istituto di Matematica dell’Università di Trieste: an International Journal of Mathematics vol.53 (2021)

, 2021
The journal Rendiconti dell’Istituto di Matematica dell’Università di Trieste was founded in 1969 by Arno Predonzan, with the aim of publishing original research articles in all fields of mathematics. Rendiconti dell’Istituto di Matematica dell’Universit`
Università degli Studi di Trieste, Dipartimento di Matematica e Informatica
core   +1 more source

Subtype‐specific enhancer RNAs define transcriptional regulators and prognosis in breast cancers

Molecular Oncology, EarlyView.
This study employed machine learning methodologies to perform the subtype‐specific classification of RNA‐seq data sets, which are mapped on enhancers from TCGA‐derived breast cancer patients. Their integration with gene expression (referred to as ProxCReAM eRNAs) and chromatin accessibility profiles has the potential to identify lineage‐specific and ...
Aamena Y. Patel, Peyman Zarrineh, Nathnael T. Tuffa, Jigar H. Sheth, Sumitra Mohan, Mudassar Iqbal, Sankari Nagarajan   +6 more
wiley   +1 more source

Presentazione di “Secolo che ci squarti, secolo che ci incanti. Studi sulla tradizione del moderno". Un dibattito su Matematica e letteratura.

, 2020
Le connessioni fra la letteratura e la matematica non sono di mero carattere estetico, ma consistono in contenuti affini. In particolare riflettiamo sul modo in cui la matematica del secolo scorso contribuisca a definire la “modernità”. Secondo Reinhart
E. Di Lorenzo
core