Results 51 to 60 of about 23,411 (246)
Complete integrability of information processing by biochemical reactions [PDF]
, 2016 Statistical mechanics provides an effective framework to investigate information processing in biochemical reactions. Within such framework far-reaching analogies are established among (anti-) cooperative collective behaviors in chemical kinetics, (anti-)
Agliari, Elena +3 more
core +3 more sources
Molecular Oncology, EarlyView.Clinical trials on PARP inhibitors in urothelial carcinoma (UC) showed limited efficacy and a lack of predictive biomarkers. We propose SLFN5, SLFN11, and OAS1 as UC‐specific response predictors. We suggest Talazoparib as the better PARP inhibitor for UC than Olaparib.
Jutta Schmitz +15 more
wiley +1 more source
Molecular Oncology, EarlyView.Development of therapies targeting cancer‐associated fibroblasts (CAFs) necessitates preclinical model systems that faithfully represent CAF–tumor biology. We established an in vitro coculture system of patient‐derived pancreatic CAFs and tumor cell lines and demonstrated its recapitulation of primary CAF–tumor biology with single‐cell transcriptomics ...
Elysia Saputra +10 more
wiley +1 more source
Research and learning environment: the role of the teacher [PDF]
, 2005 In this paper, starting from a didactical proposal about the introduction of the concept of natural number, already experienced in some primary school classes, we report about the subsequent reorganization of it in a new experience, quite different from ...
VACCARO, VIRGINIA
core
How glassy are neural networks?
, 2012 In this paper we continue our investigation on the high storage regime of a neural network with Gaussian patterns. Through an exact mapping between its partition function and one of a bipartite spin glass (whose parties consist of Ising and Gaussian ...
Adriano Barra +18 more
core +1 more source
Dual targeting of RET and SRC synergizes in RET fusion‐positive cancer cells
Molecular Oncology, EarlyView.Despite the strong activity of selective RET tyrosine kinase inhibitors (TKIs), resistance of RET fusion‐positive (RET+) lung cancer and thyroid cancer frequently occurs and is mainly driven by RET‐independent bypass mechanisms. Son et al. show that SRC TKIs significantly inhibit PAK and AKT survival signaling and enhance the efficacy of RET TKIs in ...
Juhyeon Son +13 more
wiley +1 more source
Educar em Revista, 2011 A apresentação trata da evolução da chamada psicologia da educação matemática no Brasil, traçando os temas e as linhas teóricas desenvolvidas pelo Grupo de Pesquisa em Psicologia e Educação Matemática (PSIEM) da FE/UNICAMP, surgido no final da década de ...
Márcia Regina Ferreira de Brito
doaj +1 more source
Revista Prática Docente, 2020 Resumo: O presente artigo trata-se de um recorte de dissertação de mestrado em Educação Matemática. O problema surge da análise de duas tendências que tratamos de articular, por um lado os dados indicam eventuais falhas no aprendizado da matemática e por
Martielle Soledade Souza Santos +1 more
doaj +1 more source
Molecular Oncology, EarlyView.We developed and validated a DNA methylation–based biomarker panel to distinguish pleural mesothelioma from other pleural conditions. Using the IMPRESS technology, we translated this panel into a clinically applicable assay. The resulting two classifier models demonstrated excellent performance, achieving high AUC values and strong diagnostic accuracy.
Janah Vandenhoeck +12 more
wiley +1 more source
A hybrid supervised/unsupervised machine learning approach to solar flare prediction [PDF]
, 2017 We introduce a hybrid approach to solar flare prediction, whereby a supervised regularization method is used to realize feature importance and an unsupervised clustering method is used to realize the binary flare/no-flare decision.
Benvenuto, Federico +3 more
core +3 more sources