Results 81 to 90 of about 17,768 (255)
Journal of Fungi, 2021 Rezafungin is a novel echinocandin in Phase 3 development for prevention of invasive fungal disease caused by Candida spp., Aspergillus spp. and Pneumocystis jirovecii in blood and marrow transplantation patients.
Melanie T. Cushion, Alan Ashbaugh
doaj +1 more source
Next-generation sequencing approach for connecting secondary metabolites to biosynthetic gene clusters in fungi [PDF]
, 2015 Genomics has revolutionized the research on fungal secondary metabolite (SM) biosynthesis. To elucidate the molecular and enzymatic mechanisms underlying the biosynthesis of a specific SM compound, the important first step is often to find the genes that
Cacho, Ralph A. +2 more
core +1 more source
Current Opinion in Infectious Diseases, 2014 Echinocandin resistance in Candida is a great concern, as the echinocandin drugs are recommended as first-line therapy for patients with invasive candidiasis. Here, we review recent advances in our understanding of the epidemiology, underlying mechanisms, methods for detection and clinical implications.Echinocandin resistance has emerged over the ...
Maiken Cavling Arendrup, David S. Perlin
openaire +3 more sources
Hematological Oncology, Volume 43, Issue 5, September 2025.ABSTRACT Infections often complicate pediatric‐inspired treatments for adult Philadelphia‐negative acute lymphoblastic leukemia (Ph‐ ALL). Literature data on these complications are difficult to interpret due to the heterogeneity of types of infections analyzed or patients and treatment characteristics.
Patrizia Zappasodi +27 more
wiley +1 more source
Portrait of matrix gene expression in Candida glabrata biofilms with stress induced by different drugs [PDF]
, 2018 (1) Background: Candida glabrata is one of the most significant Candida species associated with severe cases of candidiasis. Biofilm formation is an important feature, closely associated with antifungal resistance, involving alterations of gene ...
Henriques, Mariana, Rodrigues, Célia F.
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iLABMED, Volume 3, Issue 3, Page 258-262, September 2025.ABSTRACT This paper reports a case of Chlamydia psittaci pneumonia and pulmonary aspergillosis with concurrent liver injury. The patient was admitted to the hospital with coughing, expectoration, and fever for 5 days. Laboratory tests upon admission revealed abnormalities in liver function.
Chang Song +5 more
wiley +1 more source
Titan cell production in Cryptococcus neoformans reshapes the cell wall and capsule composition during infection [PDF]
, 2018 This work was supported by the National Institutes of Health (R01AI080275 and R21AI22352), the NIH Fogarty International Center (R25TW009345), the University of Minnesota Center for Translational Science Institute (UL1TR000114), Wellcome Trust (086827 ...
Gow, Neil A R +5 more
core +1 more source
Histone deacetylase inhibition as an alternative strategy against invasive aspergillosis. [PDF]
, 2015 Invasive aspergillosis (IA) is a life-threatening infection due to Aspergillus fumigatus and other Aspergillus spp. Drugs targeting the fungal cell membrane (triazoles, amphotericin B) or cell wall (echinocandins) are currently the sole therapeutic ...
Juvvadi, P.R. +2 more
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Reviews Of Anti‐infective Agents: Anidulafungin: A Novel Echinocandin [PDF]
Clinical Infectious Diseases, 2006 Until recently, the treatment available for serious fungal infections was composed of amphotericin B and azoles, and each class demonstrated significant limitations. Echinocandins are a new class of drugs that have shown promising results in treating a variety of fungal infections.
Jose A. Vazquez, Jack D. Sobel
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Mycoses, Volume 68, Issue 9, September 2025.ABSTRACT Background Starting from 2018 onwards, several outbreaks of fluconazole‐resistant C. parapsilosis have been reported in many countries worldwide. Objectives Here we report a retrospective study on C. parapsilosis blood isolates collected over 7 years (2018–2024) in two hospitals in Northern Italy.
Giorgia Palladini +12 more
wiley +1 more source