Results 11 to 20 of about 21,210 (293)

Recent Insights into the Paradoxical Effect of Echinocandins [PDF]

Journal of Fungi, 2017
Echinocandin antifungals represent one of the most important drug classes for the treatment of invasive fungal infections. The mode of action of the echinocandins relies on inhibition of the β-1,3-glucan synthase, an enzyme essentially required for the ...
Johannes Wagener, Veronika Loiko
doaj   +6 more sources

Echinocandins in antifungal pharmacotherapy [PDF]

Journal of Pharmacy and Pharmacology, 2017
Abstract Objectives Echinocandins are the newest addition of the last decade to the antifungal armamentarium, which, owing to their unique mechanism of action, selectively target the fungal cells without affecting mammalian cells.
A. Patil, S. Majumdar
semanticscholar   +4 more sources

Insight into advances for the biosynthetic progress of fermented echinocandins of antifungals

Microbial Biotechnology, 2023
Invasive fungal infections have increased remarkably, which have become unprecedented concern to human health. However, the effectiveness of current antifungal drugs is limited due to drug resistance and toxic side‐effects.
Kaili Jiang, Pan Luo, Xinxin Wang, Ling Lu   +3 more
doaj   +2 more sources

Adaptative survival of Aspergillus fumigatus to echinocandins arises from cell wall remodeling beyond β−1,3-glucan synthesis inhibition

Nature Communications
Antifungal echinocandins inhibit the biosynthesis of β−1,3-glucan, a major and essential polysaccharide component of the fungal cell wall. However, the efficacy of echinocandins against the pathogen Aspergillus fumigatus is limited.
Malitha C. Dickwella Widanage, Isha Gautam, Daipayan Sarkar, Frederic Mentink-Vigier, Josh V. Vermaas, Shi-You Ding, Andrew S. Lipton, Thierry Fontaine, Jean-Paul Latgé, Ping Wang, Tuo Wang   +10 more
doaj   +2 more sources

Rezafungin—Mechanisms of Action, Susceptibility and Resistance: Similarities and Differences with the Other Echinocandins

Journal of Fungi, 2020
Rezafungin (formerly CD101) is a new β-glucan synthase inhibitor that is chemically related with anidulafungin. It is considered the first molecule of the new generation of long-acting echinocandins. It has several advantages over the already approved by
Guillermo Garcia-Effron
doaj   +2 more sources

Resistance to Echinocandins Complicates a Case of Candida albicans Bloodstream Infection: A Case Report

Journal of Fungi, 2021
Invasive candidiasis is known to be one of the most common healthcare-associated complications and is caused by several Candida species. First-line drugs, particularly echinocandins, are effective, but there are increasing reports of resistance to these ...
Laura Trovato, Dafne Bongiorno, Maddalena Calvo, Giuseppe Migliorisi, Albino Boraccino, Nicolò Musso, Salvatore Oliveri, Stefania Stefani, Guido Scalia   +8 more
doaj   +2 more sources

Candida albicans and Candida dubliniensis Show Different Trailing Effect Patterns When Exposed to Echinocandins and Azoles

Frontiers in Microbiology, 2020
When Candida albicans and Candida dubliniensis isolates were tested for susceptibility to fluconazole and echinocandins using either EUCAST or Etest methods, differential patterns of growth were observed, independently of the methods used.
Rania Ayadi, Emilie Sitterlé, Emilie Sitterlé, Christophe d’Enfert, Eric Dannaoui, Eric Dannaoui, Marie-Elisabeth Bougnoux, Marie-Elisabeth Bougnoux   +7 more
doaj   +2 more sources

Susceptibility of Candida glabrata biofilms to echinocandins: alterations in the matrix composition [PDF]

Biofouling (Print), 2018
Candidiases are the most recurrent fungal infections, especially among immunosuppressed patients. Although Candida albicans is still the most widespread isolated species, non-Candida albicans Candida species have been increasing.
Arendrup MC, Célia F. Rodrigues, De Luca C, Grandesso S, Jabra-rizk MA, Maria Elisa Rodrigues, Mariana Henriques, Pappas PG, Pfaller MA, Williams DW   +9 more
core   +2 more sources

FDA-Approved Antibacterials and Echinocandins

Antibiotics
Since 1955, a total of 12 peptide-based drugs with antimicrobial or antifungal properties have received approval from the Food and Drug Administration (FDA).
Othman Al Musaimi
doaj   +4 more sources

Echinocandins: The Expanding Antifungal Armamentarium.

Clinical Infectious Diseases, 2015
The echinocandins are large lipopeptide molecules that, since their discovery approximately 41 years ago, have emerged as important additions to the expanding armamentarium against invasive fungal diseases.
Daniel Aguilar-Zapata, R. Petraitienė, V. Petraitis   +2 more
semanticscholar   +4 more sources