Results 11 to 20 of about 21,836 (300)
Recent Insights into the Paradoxical Effect of Echinocandins [PDF]
Journal of Fungi, 2017 Echinocandin antifungals represent one of the most important drug classes for the treatment of invasive fungal infections. The mode of action of the echinocandins relies on inhibition of the β-1,3-glucan synthase, an enzyme essentially required for the ...
Johannes Wagener, Veronika Loiko
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Echinocandins in antifungal pharmacotherapy [PDF]
Journal of Pharmacy and Pharmacology, 2017 Abstract Objectives Echinocandins are the newest addition of the last decade to the antifungal armamentarium, which, owing to their unique mechanism of action, selectively target the fungal cells without affecting mammalian cells.
A. Patil, S. Majumdar
semanticscholar +4 more sources
Insight into advances for the biosynthetic progress of fermented echinocandins of antifungals
Microbial Biotechnology, 2023 Invasive fungal infections have increased remarkably, which have become unprecedented concern to human health. However, the effectiveness of current antifungal drugs is limited due to drug resistance and toxic side‐effects.
Kaili Jiang +3 more
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Nature CommunicationsAntifungal echinocandins inhibit the biosynthesis of β−1,3-glucan, a major and essential polysaccharide component of the fungal cell wall. However, the efficacy of echinocandins against the pathogen Aspergillus fumigatus is limited.
Malitha C. Dickwella Widanage +10 more
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Journal of Fungi, 2020 Rezafungin (formerly CD101) is a new β-glucan synthase inhibitor that is chemically related with anidulafungin. It is considered the first molecule of the new generation of long-acting echinocandins. It has several advantages over the already approved by
Guillermo Garcia-Effron
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Treatment of Primary Pulmonary Aspergillosis: An Assessment of the Evidence [PDF]
Journal of Fungi, 2016 Aspergillus spp. are a group of filamentous molds that were first described due to a perceived similarity to an aspergillum, or liturgical device used to sprinkle holy water, when viewed under a microscope.
Ethan R. Stewart, George R. Thompson
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Micafungin: a sulfated echinocandin [PDF]
The Journal of Antibiotics, 2009 AbstractChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 200 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
Seiji Hashimoto
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Comparison of echinocandin antifungals
Therapeutics and Clinical Risk Management, 2007 The incidence of invasive fungal infections, especially those due to Aspergillus spp. and Candida spp., continues to increase. Despite advances in medical practice, the associated mortality from these infections continues to be substantial. The echinocandin antifungals provide clinicians with another treatment option for serious fungal infections ...
Gregory Eschenauer +2 more
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FDA-Approved Antibacterials and Echinocandins
AntibioticsSince 1955, a total of 12 peptide-based drugs with antimicrobial or antifungal properties have received approval from the Food and Drug Administration (FDA).
Othman Al Musaimi
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Fungal echinocandin resistance [PDF]
Fungal Genetics and Biology, 2010 The echinocandins are the newest class of antifungal agents in the clinical armory. These secondary metabolites are non-competitive inhibitors of the synthesis of beta-(1,3)-glucan, a major structural component of the fungal cell wall. Recent work has shown that spontaneous mutations can arise in two hot spot regions of Fks1 the target protein of ...
Neil A. R. Gow +2 more
openaire +6 more sources