Results 41 to 50 of about 17,763 (261)

Tolerance and heteroresistance to echinocandins in <i>Candida auris</i>: conceptual issues, clinical implications, and outstanding questions. [PDF]

mSphere
Shor E, Perlin DS, Kontoyiannis DP.
europepmc   +2 more sources

Echinocandins in antifungal pharmacotherapy [PDF]

Journal of Pharmacy and Pharmacology, 2017
Abstract Objectives Echinocandins are the newest addition of the last decade to the antifungal armamentarium, which, owing to their unique mechanism of action, selectively target the fungal cells without affecting mammalian cells.
Akash Patil, Soumyajit Majumdar
openaire   +2 more sources

FKS1 Is Required for Cryptococcus neoformans Fitness In Vivo: Application of Copper-Regulated Gene Expression to Mouse Models of Cryptococcosis

mSphere, 2022
There is an urgent need for new antifungals to treat cryptococcal meningoencephalitis, a leading cause of mortality in people living with HIV/AIDS. An important aspect of antifungal drug development is the validation of targets to determine whether they ...
Sarah R. Beattie, Andrew J. Jezewski, Laura C. Ristow, Melanie Wellington, Damian J. Krysan   +4 more
doaj   +1 more source

Breakthrough Candidemia Due to Multidrug-Resistant Candida glabrata during Prophylaxis with a Low Dose of Micafungin [PDF]

, 2014
We identified a case of breakthrough candidemia in a 25-year-old patient receiving micafungin prophylaxis (50 mg/day). Five Candida glabrata isolates were obtained from blood cultures and were classified as multidrug-resistant isolates, since all of them
Bizerra, Fernando Cesar, Breda, Giovanni Luis, Colombo, Arnaldo L., Jimenez-Ortigosa, Cristina, Perlin, David S., Queiroz-Telles, Flavio, Souza, Ana Carolina R.   +6 more
core   +2 more sources

Clinical and Laboratory Development of Echinocandin Resistance in Candida glabrata: Molecular Characterization

Frontiers in Microbiology, 2019
The pathogenic yeast Candida glabrata has become a public health issue due to the increasing number of echinocandin resistant clinical strains reported.
Olga Rivero-Menendez, Patricia Navarro-Rodriguez, Leticia Bernal-Martinez, Leticia Bernal-Martinez, Gema Martin-Cano, Laura Lopez-Perez, Isabel Sanchez-Romero, Ana Perez-Ayala, Javier Capilla, Oscar Zaragoza, Oscar Zaragoza, Ana Alastruey-Izquierdo, Ana Alastruey-Izquierdo   +12 more
doaj   +1 more source

Accumulation of Trehalose 6-Phosphate in Candidozyma auris results in Decreased Echinocandin Resistance and Tolerance. [PDF]

Nat Commun
Zhu Q, Van de Velde S, Wijnants S, Carolus H, Jacobs S, Sofras D, Vandecruys P, Van Goethem O, Feil R, Vergauwen R, Van Genechten W, Van den Ende W, Rybak JM, Himmelreich U, Lunn JE, Van Dijck P.   +15 more
europepmc   +3 more sources

The Surgical Infection Society revised guidelines on the management of intra-abdominal infection [PDF]

, 2017
Background: Previous evidence-based guidelines on the management of intra-abdominal infection (IAI) were published by the Surgical Infection Society (SIS) in 1992, 2002, and 2010. At the time the most recent guideline was released, the plan was to update
Chang, Phillip K, Diaz, Jose J, Jr, Huston, Jared M, May, Addison K, Mazuski, John E, Mollen, Kevin P, Nadler, Evan P, O\u27Neill, Patrick J, Prince, Jose M, Rosengart, Matthew R, Sawyer, Robert G, Tessier, Jeffrey M   +11 more
core   +3 more sources

Antifungal effects of echinocandins diminish when exposed to intestinal lumen contents: a finding with potentially significant clinical implications

Frontiers in Pharmacology
Echinocandins, a prominent class of antifungals, are known for their broad-spectrum activity and favorable safety profiles. However, their bioavailability and efficacy via oral route are suboptimal. In this study, caspofungin and micafungin, the two most
Sepideh Mehravar, Gabriela S. Leite, Mark Pimentel, Mark Pimentel, Ali Rezaie, Ali Rezaie   +5 more
doaj   +1 more source

The problem of systemic candidosis after transplantation of solid organs. Review of the literature

Трансплантология (Москва), 2018
The article presents current views on the epidemiology, diagnosis and treatment of candidosis with organ transplantation.
S. V. Zhuravel, A. O. Chugunov, T. V. Chernenkaya   +2 more
doaj   +1 more source

Combined antifungal resistance and biofilm tolerance: the global threat of Candida auris [PDF]

, 2019
The enigmatic yeast Candida auris has emerged over the last decade and rapidly penetrated our consciousness. The global threat from this multidrug-resistant yeast has generated a call to arms from within the medical mycology community.
Kean, Ryan, Ramage, Gordon
core   +2 more sources