Results 61 to 70 of about 21,210 (293)

A Prospective Surveillance Study of Candidaemia : Epidemiology, Risk Factors, Antifungal Treatment and Outcome in Hospitalized Patients [PDF]

, 2016
Funding This work was supported by the Wellcome Trust Strategic Award for Medical Mycology and Fungal Immunology 097377/Z/11/Z. Data collection was supported by a grant from Pfizer.
Deshpande, Ashutosh, Hanson, Mary F., Johnson, Elizabeth M., Jones, Brian L., Munro, Carol A., Rajendran, Ranjith, Ramage, Gordon, Sherry, Leighann, Williams, Craig   +8 more
core   +2 more sources

Antifungal effects of echinocandins diminish when exposed to intestinal lumen contents: a finding with potentially significant clinical implications

Frontiers in Pharmacology
Echinocandins, a prominent class of antifungals, are known for their broad-spectrum activity and favorable safety profiles. However, their bioavailability and efficacy via oral route are suboptimal. In this study, caspofungin and micafungin, the two most
Sepideh Mehravar, Gabriela S. Leite, Mark Pimentel, Mark Pimentel, Ali Rezaie, Ali Rezaie   +5 more
doaj   +1 more source

The seizure of illicit assets: patterns of civil forfeiture in Canada and Ireland [PDF]

, 2013
No description ...
Gallant, M Michelle, King, Colin
core   +1 more source

Comparative evaluation of Sensititre YeastOne and CLSI M38-Ed3 reference method for determining echinocandin minimum effective concentrations against Aspergillus isolates

Microbiology Spectrum
The minimum inhibitory concentration (MIC) of echinocandins against Aspergillus spp. does not represent the actual inhibition threshold of echinocandins.
Assaf Potruch, Hila Elinav, Matan J. Cohen, Alexander Rouvinski, Itzhack Polacheck, Maya Korem   +5 more
doaj   +1 more source

Successful management of recalcitrant fungal keratitis with topical caspofungin

GMS Ophthalmology Cases, 2022
Objective: To report a case of recalcitrant fungal keratitis successfully managed with topical caspofungin acetate in North India.Methods: Case report and literature review.Results: An 18-year-old male patient presented with complaints of redness ...
Goel, Siddhi, Sharma, Arpit, Sinha, Rajesh   +2 more
doaj   +1 more source

Set of Classical PCRs for Detection of Mutations in Candida glabrata FKS Genes Linked with Echinocandin Resistance [PDF]

, 2014
Clinical echinocandin resistance among Candida glabrata strains is increasing, especially in the United States. Antifungal susceptibility testing is considered mandatory to guide therapeutic decisions.
Afeltra, Javier, Dudiuk, Catiana Beatriz, Gamarra, Maria Soledad, Garcia, Guillermo Manuel, Jimenez Ortigoza, Cristina, Leonardelli, Florencia, Perlin, David S., Vitale, Roxana Gabriela   +7 more
core   +2 more sources

Acrophiarin (antibiotic S31794/F-1) from Penicillium arenicola shares biosynthetic features with both Aspergillus- and Leotiomycete-type echinocandins.

Environmental Microbiology, 2020
The antifungal echinocandin lipopeptide, acrophiarin, was circumscribed in a patent in 1979. We confirmed that the producing strain NRRL 8095 is Penicillium arenicola and other strains of P.
N. Lan, Bruno Perlatti, Daniel J. Kvitek, Philipp Wiemann, Colin J. B. Harvey, J. Frisvad, Z. An, G. Bills   +7 more
semanticscholar   +1 more source

Epidemiology of Echinocandin Resistance in Candida [PDF]

Current Fungal Infection Reports, 2014
Echinocandins are the newest antifungal agents approved for use in treating Candida infections in the US. They act by interfering with 1,3-β-D-glucan synthase and therefore disrupt cell wall production and lead to Candida cell death. There is no intrinsic resistance to echinocandins among Candida species, and isolates from historic collections archived
Shawn R. Lockhart, Tom Chiller, Nina T. Grossman   +2 more
openaire   +3 more sources

Identification of Genes in Candida glabrata Conferring Altered Responses to Caspofungin, a Cell Wall Synthesis Inhibitor

G3: Genes, Genomes, Genetics, 2016
Candida glabrata is an important human fungal pathogen whose incidence continues to rise. Because many clinical isolates are resistant to azole drugs, the drugs of choice to treat such infections are members of the echinocandin family, although there are
Anne G. Rosenwald, Gaurav Arora, Rocco Ferrandino, Erica L. Gerace, Maedeh Mohammednetej, Waseem Nosair, Shemona Rattila, Amanda Zirzow Subic, Ronda Rolfes   +8 more
doaj   +1 more source

Molecular Mechanisms Associated with Antifungal Resistance in Pathogenic Candida Species

Cells, 2023
Candidiasis is a highly pervasive infection posing major health risks, especially for immunocompromised populations. Pathogenic Candida species have evolved intrinsic and acquired resistance to a variety of antifungal medications.
Karolina M. Czajka, Krishnan Venkataraman, Danielle Brabant-Kirwan, Stacey A. Santi, Chris Verschoor, Vasu D. Appanna, Ravi Singh, Deborah P. Saunders, Sujeenthar Tharmalingam   +8 more
doaj   +1 more source