Results 71 to 80 of about 17,763 (261)

Effectiveness of an antifungal stewardship programme at a London teaching hospital 2010–16 [PDF]

, 2019
Background The need for antifungal stewardship is gaining recognition with increasing incidence of invasive fungal infection (IFI) and antifungal resistance alongside the high cost of antifungal drugs.
Al-Ghusein, H, Ball, J, Bicanic, T, Glass, S, Houston, A, Klammer, M, Koh, M, Wake, R, Whitney, L, Youngs, J   +9 more
core   +1 more source

Comparison of echinocandin antifungals

Therapeutics and Clinical Risk Management, 2007
The incidence of invasive fungal infections, especially those due to Aspergillus spp. and Candida spp., continues to increase. Despite advances in medical practice, the associated mortality from these infections continues to be substantial. The echinocandin antifungals provide clinicians with another treatment option for serious fungal infections ...
Gregory, Eschenauer, Daryl D, Depestel, Peggy L, Carver   +2 more
openaire   +3 more sources

Targeted Therapy of Fungal Keratitis Enabled by Iron Nutritional Deprivation Combined With Photothermal Effect

Small Structures, Volume 7, Issue 1, January 2026.
This work developed a PDC nanoplatform that orchestrated a multimodal synergistic therapy, combining active targeting, photothermal therapy, and iron nutrient deprivation. The antifungal, anti‐inflammatory efficacy and corneal repair ability of nanoplatform were demonstrated through both in vitro and in vivo evaluations.
Ruojiao Feng, Lingshuai Meng, Shuping Zhang, Jie Zhang, Chuchu Hu, Jiaxin Zhang, Junchao Xia, Xiaoshuo Yue, Quanlin Wang, Xiaoran Liu, Wenruo Xu, Yinglun Sun, Panhong Niu, Hua Gao   +13 more
wiley   +1 more source

Adaptative survival of Aspergillus fumigatus to echinocandins arises from cell wall remodeling beyond β−1,3-glucan synthesis inhibition

Nature Communications
Antifungal echinocandins inhibit the biosynthesis of β−1,3-glucan, a major and essential polysaccharide component of the fungal cell wall. However, the efficacy of echinocandins against the pathogen Aspergillus fumigatus is limited.
Malitha C. Dickwella Widanage, Isha Gautam, Daipayan Sarkar, Frederic Mentink-Vigier, Josh V. Vermaas, Shi-You Ding, Andrew S. Lipton, Thierry Fontaine, Jean-Paul Latgé, Ping Wang, Tuo Wang   +10 more
doaj   +1 more source

APX001 Is Effective in the Treatment of Murine Invasive Pulmonary Aspergillosis. [PDF]

, 2019
Invasive pulmonary aspergillosis (IPA) due to Aspergillus fumigatus is a serious fungal infection in the immunosuppressed patient population. Despite the introduction of new antifungal agents, mortality rates remain high, and new treatments are needed ...
Alkhazraji, Sondus, Alqarihi, Abdullah, Gebremariam, Teclegiorgis, Gu, Yiyou, Ibrahim, Ashraf S, Jeon, Heewon H, Kapoor, Mili, Shaw, Karen J   +7 more
core  

Resistance in Candida albicans: exploring the cell wall barrier by proteomics [PDF]

, 2015
The incidence of candidiasis has dramatically increased and bloodstream infections due to different species of Candida are becoming a prime cause of morbidity and mortality in different types of immunocompromised patients.
Angiolella, Letizia, Maras, Bruno, Mignogna, Giuseppina   +2 more
core   +1 more source

Emerging Frontiers in Clinical Mycology: Innovations, Insights, and Impacts

Mycoses, Volume 69, Issue 1, January 2026.
ABSTRACT The Mycoses Study Group Education and Research Consortium (MSGERC)—a group comprising clinicians, researchers, patients, and industry partners—meets every 2 years to review the most significant challenges facing the clinical mycology community and plan research, education, and advocacy strategies to prevent fungal infections and improve ...
A. Apostolopoulou, A. G. Stewart, H. Yoon, J. M. Steinbrink, D. Z. P. Friedman, L. Ostrosky‐Zeichner, I. S. Schwartz, on behalf of the Mycoses Study Group Education and Research Consortium (MSGERC)   +7 more
wiley   +1 more source

Some issues of the resistance of Candida glabrata to echinocandins [PDF]

Клиническая микробиология и антимикробная химиотерапия, 2019
Invasive candidiasis is a common, severe and often difficult to treat complication in various categories of patients. Despite the fact that in most cases Candida albicans retains a leading position as an etiological cause, a pathogen such as Candida ...
Veselov A.V.
doaj   +1 more source

De-escalation from Echinocandins to Azole Treatment in Critically Ill Patients with Candidemia

International Journal of Infectious Diseases, 2022
Objectives: This study aims to further explore the duration of echinocandins and analyze the de-escalation (DE) strategy in patients with candidemia. Methods: Multivariable logistic regression was used to evaluate the association between the duration of ...
Jing Lin, Menglan Zhou, Jialong Chen, Li Zhang, Minya Lu, Zhengyin Liu   +5 more
doaj   +1 more source

Pitfalls associated with the use of molecular diagnostic panels in the diagnosis of cryptococcal meningitis [PDF]

, 2017
We report the case of a kidney transplantation patient on chronic immunosuppressive therapy presenting with subacute meningitis. The final diagnosis of cryptococcal meningitis was delayed due to 2 false-negative cryptococcal results on a molecular ...
Burnham, Carey-Ann, Dubberke, Erik, Franklin, Alexander, Lainhart, William, O\u27Halloran, Jane A, Powderly, William   +5 more
core   +2 more sources