Results 21 to 30 of about 227,310 (233)

Mechanical Forces as Determinants of Disseminated Metastatic Cell Fate

open access: yesCells, 2020
Disseminated metastatic cancer cells represent one of the most relevant causes of disease relapse and associated death for cancer patients, and a therapeutic target of the highest priority.
Marco Montagner, Sirio Dupont
doaj   +1 more source

On micromachining with a focus on miniature gears by non conventional processes: a status report [PDF]

open access: yesArchive of Mechanical Engineering, 2018
Recent developments in automation and technology have revolutionized the way products are made. It is directly seen in the evolution of part miniaturization in the sectors such as aerospace, electronics, biomedicine and medical implants.
Tina Chaudhary   +3 more
doaj   +1 more source

Neural ECM mimetics [PDF]

open access: yes, 2014
The consequence of numerous neurological disorders is the significant loss of neural cells, which further results in multilevel dysfunction or severe functional deficits. The extracellular matrix (ECM) is of tremendous importance for neural regeneration mediating ambivalent functions: ECM serves as a growth-promoting substrate for neurons but, on the ...
Estrada, V.   +2 more
openaire   +6 more sources

Structural instability impairs function of the UDP‐xylose synthase 1 Ile181Asn variant associated with short‐stature genetic syndrome in humans

open access: yesFEBS Letters, EarlyView.
The Ile181Asn variant of human UDP‐xylose synthase (hUXS1), associated with a short‐stature genetic syndrome, has previously been reported as inactive. Our findings demonstrate that Ile181Asn‐hUXS1 retains catalytic activity similar to the wild‐type but exhibits reduced stability, a looser oligomeric state, and an increased tendency to precipitate ...
Tuo Li   +2 more
wiley   +1 more source

The impact of educational expenditures of government on economic growth of Iran

open access: yesAD-minister, 2017
Using the annual data of Iran’s economy from 1981-2012, this study examines Wagner’s law and the Keynesian hypothesis about the relationship between the real government expenditure and the real GDP.
Fozieh Jeyhoon Tabar   +2 more
doaj   +1 more source

In vitro models of cancer‐associated fibroblast heterogeneity uncover subtype‐specific effects of CRISPR perturbations

open access: yesMolecular Oncology, EarlyView.
Development of therapies targeting cancer‐associated fibroblasts (CAFs) necessitates preclinical model systems that faithfully represent CAF–tumor biology. We established an in vitro coculture system of patient‐derived pancreatic CAFs and tumor cell lines and demonstrated its recapitulation of primary CAF–tumor biology with single‐cell transcriptomics ...
Elysia Saputra   +10 more
wiley   +1 more source

A Novel 3D Scaffold for Cell Growth to Assess Electroporation Efficacy

open access: yesCells, 2019
Tumor electroporation (EP) refers to the permeabilization of the cell membrane by means of short electric pulses thus allowing the potentiation of chemotherapeutic drugs.
Monica Dettin   +9 more
doaj   +1 more source

Forecasting Macroeconomic Variables and their Effect on Poverty

open access: yesJournal of Economics, Business & Accountancy Ventura, 2023
Forecasting macroeconomic variables is crucial to measure dynamic changes during uncertain economic conditions. This study examines and analyzes the appropriate and accurate forecasting model to predict macroeconomic variables in Maluku Province.
Muhammad Ridhwan Assel   +3 more
doaj   +1 more source

Extracellular Matrix (ECM) [PDF]

open access: yes, 2012
The region of space at the periphery of cyanobacterial cells is the interface between the environment and intracellular processes. This metaspace may include a structure appressed to the outer wall and membrane, such as an extracellular polysaccharide (EPS), a structural and/or physiological discontinuity in the control of flow metabolites, as well as ...
Helm R.F., Potts M.
openaire   +3 more sources

Transcriptional network analysis of PTEN‐protein‐deficient prostate tumors reveals robust stromal reprogramming and signs of senescent paracrine communication

open access: yesMolecular Oncology, EarlyView.
Combining PTEN protein assessment and transcriptomic profiling of prostate tumors, we uncovered a network enriched in senescence and extracellular matrix (ECM) programs associated with PTEN loss and conserved in a mouse model. We show that PTEN‐deficient cells trigger paracrine remodeling of the surrounding stroma and this information could help ...
Ivana Rondon‐Lorefice   +16 more
wiley   +1 more source

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