Nociceptive Sensory Neurons Mediate Inflammation Induced by Bacillus Anthracis Edema Toxin [PDF]
Frontiers in Immunology, 2021 Bacterial products are able to act on nociceptive neurons during pathogenic infection. Neurogenic inflammation is an active part of pain signaling and has recently been shown to impact host-pathogen defense.
Nicole J. Yang +7 more
doaj +5 more sources
ATP depletion in anthrax edema toxin pathogenesis. [PDF]
PLoS PathogensAnthrax lethal toxin (LT) and edema toxin (ET) are two of the major virulence factors of Bacillus anthracis, the causative pathogen of anthrax disease. While the roles of LT in anthrax pathogenesis have been extensively studied, the pathogenic mechanism ...
Jie Liu +7 more
doaj +4 more sources
Anthrax edema toxin disrupts distinct steps in Rab11-dependent junctional transport. [PDF]
PLoS Pathogens, 2017 Various bacterial toxins circumvent host defenses through overproduction of cAMP. In a previous study, we showed that edema factor (EF), an adenylate cyclase from Bacillus anthracis, disrupts endocytic recycling mediated by the small GTPase Rab11.
Annabel Guichard +12 more
doaj +5 more sources
Anthrax Vaccine Precipitated Induces Edema Toxin-Neutralizing, Edema Factor-Specific Antibodies in Human Recipients. [PDF]
Clin Vaccine Immunol, 2017 ABSTRACT Edema toxin (ET), composed of edema factor (EF) and protective antigen (PA), is a virulence factor of Bacillus anthracis that alters host immune cell function and contributes to anthrax disease. Anthrax vaccine precipitated (AVP) contains low but detectable levels of EF and can elicit EF-specific ...
Dumas EK +13 more
europepmc +3 more sources
Anthrax edema toxin impairs clearance in mice. [PDF]
Infect Immun, 2012 ABSTRACT The anthrax edema toxin (ET) of Bacillus anthracis is composed of the receptor-binding component protective antigen (PA) and of the adenylyl cyclase catalytic moiety, edema factor (EF). Uptake of ET into cells raises intracellular concentrations of the secondary messenger cyclic AMP, thereby ...
Sastalla I +7 more
europepmc +4 more sources
Rapid Discovery and Characterization of Synthetic Neutralizing Antibodies against Anthrax Edema Toxin. [PDF]
Biochemistry, 2019 Anthrax, a lethal, weaponizable disease caused by Bacillus anthracis, acts through exotoxins that are primary mediators of systemic toxicity and also targets for neutralization by passive immunotherapy. The ease of engineering B. anthracis strains resistant to established therapy and the historic use of the microbe in bioterrorism present a compelling ...
Farcasanu M +8 more
europepmc +4 more sources
Anthrax Edema and Lethal Toxins Differentially Target Human Lung and Blood Phagocytes [PDF]
Toxins, 2020 Bacillus anthracis, the causative agent of inhalation anthrax, is a serious concern as a bioterrorism weapon. The vegetative form produces two exotoxins: Lethal toxin (LT) and edema toxin (ET).
Vineet I. Patel +4 more
doaj +3 more sources
Structure-based redesign of an edema toxin inhibitor. [PDF]
Bioorg Med Chem, 2012 Edema factor (EF) toxin of Bacillus anthracis (NIAID category A), and several other toxins from NIAID category B Biodefense target bacteria are adenylyl cyclases or adenylyl cyclase agonists that catalyze the conversion of ATP to 3',5'-cyclic adenosine monophosphate (cAMP).
Chen D +9 more
europepmc +4 more sources
Edema toxin impairs anthracidal phospholipase A2 expression by alveolar macrophages. [PDF]
PLoS Pathogens, 2007 Bacillus anthracis, the etiological agent of anthrax, is a spore-forming gram-positive bacterium. Infection with this pathogen results in multisystem dysfunction and death. The pathogenicity of B.
Benoit Raymond +7 more
doaj +4 more sources
Micropatterned macrophage analysis reveals global cytoskeleton constraints induced by Bacillus anthracis edema toxin. [PDF]
Infect Immun, 2015 ABSTRACT Bacillus anthracis secretes the edema toxin (ET) that disrupts the cellular physiology of endothelial and immune cells, ultimately affecting the adherens junction integrity of blood vessels that in turn leads to edema.
Trescos Y +4 more
europepmc +4 more sources