Results 11 to 20 of about 33,099 (254)
Anthrax Edema Toxin Sensitizes DBA/2J Mice to Lethal Toxin [PDF]
Infection and Immunity, 2007 ABSTRACT Anthrax toxin is made up of three separate protein components: the receptor-binding protective antigen (PA), the adenylyl cyclase edema factor (EF), and the metalloproteinase lethal factor (LF). EF and PA constitute edema toxin (ET), which causes edema when injected subcutaneously.
Aaron M, Firoved +5 more
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Cellular and systemic effects of anthrax lethal toxin and edema toxin [PDF]
Molecular Aspects of Medicine, 2009 Anthrax lethal toxin (LT) and edema toxin (ET) are the major virulence factors of anthrax and can replicate the lethality and symptoms associated with the disease. This review provides an overview of our current understanding of anthrax toxin effects in animal models and the cytotoxicity (necrosis and apoptosis) induced by LT in different cells.
Mahtab, Moayeri, Stephen H, Leppla
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Инфекция и иммунитет, 2020 Here, we review the data on mechanisms inhibiting cytotoxic effect of anthrax toxin on the immune system cells. Various disease forms, immunopathogenesis and contemporary methods for anthrax treatment are discussed.
V. V. Firstova +2 more
doaj +1 more source
Development of a New Cell-Based AP-1 Gene Reporter Potency Assay for Anti-Anthrax Toxin Therapeutics
Toxins, 2023 Anthrax toxin is a critical virulence factor of Bacillus anthracis. The toxin comprises protective antigen (PA) and two enzymatic moieties, edema factor (EF) and lethal factor (LF), forming bipartite lethal toxin (LT) and edema toxin (ET).
Weiming Ouyang +3 more
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Correlation between in vitro cytotoxicity and in vivo lethal activity in mice of epsilon toxin mutants from Clostridium perfringens. [PDF]
PLoS ONE, 2014 Epsilon toxin (Etx) from Clostridium perfringens is a pore-forming protein with a lethal effect on livestock, producing severe enterotoxemia characterized by general edema and neurological alterations.
Jonatan Dorca-Arévalo +5 more
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Toxins, 2023 Edema toxin (ET), one of the main toxic factors of Bacillus anthracis (B. anthracis), is a kind of potent adenylate cyclase (AC). B. anthracis has adapted to resist macrophage microbicidal mechanisms in part by secreting ET.
Taoran Zhao +7 more
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Anthrax lethal and edema toxins in anthrax pathogenesis [PDF]
Trends in Microbiology, 2014 The pathophysiological effects resulting from many bacterial diseases are caused by exotoxins released by the bacteria. Bacillus anthracis, a spore-forming bacterium, is such a pathogen, causing anthrax through a combination of bacterial infection and toxemia. B.
Shihui, Liu +2 more
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Corneal edema due to botanical toxins
IP International Journal of Ocular Oncology and Oculoplasty, 2020 Corneal edema following contact with plant extracts occur not only with horticultural workers but also with amateur gardeners. The condition causes reasonable visual debility but is reversible and self limiting. Till date, no established therapeutic protocol exists for management of this particular condition.To re-examine the etiological factors behind
Soumen Chakraborty +1 more
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Contribution of Lethal Toxin and Edema Toxin to the Pathogenesis of Anthrax Meningitis [PDF]
Infection and Immunity, 2011 ABSTRACT Bacillus anthracis is a Gram-positive spore-forming bacterium that causes anthrax disease in humans and animals. Systemic infection is characterized by septicemia, toxemia, and meningitis, the main neurological complication associated with high mortality. We have shown previously that B. anthracis
Celia M, Ebrahimi +4 more
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Cell entry and cAMP imaging of anthrax edema toxin [PDF]
The EMBO Journal, 2006 The entry and enzymatic activity of the anthrax edema factor (EF) in different cell types was studied by monitoring EF-induced changes in intracellular cAMP with biochemical and microscopic methods. cAMP was imaged in live cells, transfected with a fluorescence resonance energy transfer biosensor based on the protein kinase A regulatory and catalytic ...
Dal Molin F +7 more
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