Results 21 to 30 of about 33,099 (254)

Cellular and physiological effects of anthrax exotoxin and its relevance to disease

Frontiers in Cellular and Infection Microbiology, 2012
Bacillus anthracis, the causative agent of anthrax, secretes a tripartite exotoxin that exerts pleiotropic effects on the host. The purification of the exotoxin components, protective antigen, lethal factor, and edema factor allowed the rapid ...
David Edward Lowe, Ian Justin Glomski
doaj   +1 more source

Bacillus anthracisEdema Toxin Impairs Neutrophil Actin-Based Motility [PDF]

Infection and Immunity, 2009
ABSTRACTInhalation anthrax results in high-grade bacteremia and is accompanied by a delay in the rise of the peripheral polymorphonuclear neutrophil (PMN) count and a paucity of PMNs in the infected pleural fluid and mediastinum. Edema toxin (ET) is one of the majorBacillus anthracisvirulence factors and consists of the adenylate cyclase edema factor ...
Sarah E, Szarowicz, Russell L, During, Wei, Li, Conrad P, Quinn, Wei-Jen, Tang, Frederick S, Southwick   +5 more
openaire   +2 more sources

T Cell Targeting by Anthrax Toxins: Two Faces of the Same Coin

Toxins, 2011
Bacillus anthracis, similar to other bacterial pathogens, has evolved effective immune evasion strategies to prolong its survival in the host, thus ensuring the unchecked spread of the infection.
Silvia Rossi Paccani, Cosima T. Baldari
doaj   +1 more source

Emergence of Anthrax Edema Toxin as a Master Manipulator of Macrophage and B Cell Functions

Toxins, 2010
Anthrax edema toxin (ET), a powerful adenylyl cyclase, is an important virulence factor of Bacillus anthracis. Until recently, only a modest amount of research was performed to understand the role this toxin plays in the organism’s immune evasion ...
Linsey A. Yeager, Scott T. Moen, Ashok K. Chopra, Johnny W. Peterson, Bryan T. Gnade   +4 more
doaj   +1 more source

Anthrax Edema Toxin Cooperates with Lethal Toxin to Impair Cytokine Secretion during Infection of Dendritic Cells [PDF]

The Journal of Immunology, 2005
AbstractBacillus anthracis secretes two critical virulence factors, lethal toxin (LT) and edema toxin (ET). In this study, we show that murine bone marrow-derived dendritic cells (DC) infected with B. anthracis strains secreting ET exhibit a very different cytokine secretion pattern than DC infected with B.
Jean-Nicolas, Tournier, Anne, Quesnel-Hellmann, Jacques, Mathieu, Cesare, Montecucco, Wei-Jen, Tang, Michèle, Mock, Dominique R, Vidal, Pierre L, Goossens   +7 more
openaire   +4 more sources

On some toxinological aspects of the starfish Stellaster equestris (Retzius, 1805)

Journal of Venomous Animals and Toxins including Tropical Diseases, 2008
Whole-body extracts in methanol were obtained from the starfish Stellaster equestris. The crude toxin was fractionated stepwise using diethylaminoethyl (DEAE) cellulose column chromatography.
U Kanagarajan, S Bragadeeswaran, K Venkateshvaran   +2 more
doaj   +1 more source

LRP5 and LRP6 are not required for protective antigen-mediated internalization or lethality of anthrax lethal toxin. [PDF]

PLoS Pathogens, 2007
Anthrax toxin (AnTx) plays a key role in the pathogenesis of anthrax. AnTx is composed of three proteins: protective antigen (PA), edema factor, and lethal factor (LF). PA is not toxic but serves to bind cells and translocate the toxic edema factor or LF
John J Young, Jennifer L Bromberg-White, Cassandra Zylstra, Joseph T Church, Elissa Boguslawski, James H Resau, Bart O Williams, Nicholas S Duesbery, Nicholas S Duesbery   +8 more
doaj   +1 more source

Recombinant Production and Characterization of a New Toxin from Cryptops iheringi Centipede Venom Revealed by Proteome and Transcriptome Analysis

Toxins, 2021
Among the Chilopoda class of centipede, the Cryptops genus is one of the most associated with envenomation in humans in the metropolitan region of the state of São Paulo. To date, there is no study in the literature about the toxins present in its venom.
Lhiri Hanna De Lucca Caetano, Milton Yutaka Nishiyama-Jr, Bianca de Carvalho Lins Fernandes Távora, Ursula Castro de Oliveira, Inácio de Loiola Meirelles Junqueira-de-Azevedo, Eliana L. Faquim-Mauro, Geraldo Santana Magalhães   +6 more
doaj   +1 more source

cAMP imaging of cells treated with pertussis toxin, cholera toxin, and anthrax edema toxin

Biochemical and Biophysical Research Communications, 2008
The enzymatic activity of the three most studied bacterial toxins that increase the cytosolic cAMP level: pertussis toxin (PT), cholera toxin (CT), and anthrax edema toxin (ET), was imaged by fluorescence videomicroscopy. Three different cell lines were transfected with a fluorescence resonance energy transfer biosensor based on the PKA regulatory and ...
DAL MOLIN F, ZORNETTA, IRENE, PUHAR A, TONELLO F, ZACCOLO M, MONTECUCCO, CESARE   +5 more
openaire   +5 more sources

Transcriptional stimulation of anthrax toxin receptors by anthrax edema toxin and Bacillus anthracis Sterne spore [PDF]

Microbial Pathogenesis, 2007
We used quantitative real-time RT-PCR to not only investigate the mRNA levels of anthrax toxin receptor 1 (ANTXR1) and 2 (ANTXR2) in the murine J774A.1 macrophage cells and different tissues of mice, but also evaluate the effect of anthrax edema toxin and Bacillus anthracis Sterne spores on the expression of mRNA of these receptors.
Qingfu, Xu, Eric D, Hesek, Mingtao, Zeng
openaire   +2 more sources