Results 31 to 40 of about 33,099 (254)
Toxins, 2019 Myeloid phagocytes have evolved to rapidly recognize invading pathogens and clear them through opsonophagocytic killing. The adenylate cyclase toxin (CyaA) of Bordetella pertussis and the edema toxin (ET) of Bacillus anthracis are both calmodulin ...
Shakir Hasan +3 more
doaj +1 more source
Contributions of Histamine, Prostanoids, and Neurokinins to Edema Elicited by Edema Toxin fromBacillus anthracis [PDF]
Infection and Immunity, 2007 ABSTRACTBacillus anthracisedema toxin (ET), composed of protective antigen and an adenylate cyclase edema factor (EF), elicits edema in host tissues, but the target cells and events leading from EF-mediated cyclic-AMP production to edema are unknown.
Jeffrey, Tessier +6 more
openaire +2 more sources
Innate Immune Interactions between Bacillus anthracis and Host Neutrophils
Frontiers in Cellular and Infection Microbiology, 2018 Bacillus anthracis, the causative agent of anthrax, has been a focus of study in host-pathogen dynamics since the nineteenth century. While the interaction between anthrax and host macrophages has been extensively modeled, comparatively little is known ...
Janet Z. Liu +4 more
doaj +1 more source
PLoS Pathogens, 2022 Inhalation anthrax has three clinical stages: early-prodromal, intermediate-progressive, and late-fulminant. We report the comprehensive characterization of anthrax toxins, including total protective antigen (PA), total lethal factor (LF), total edema ...
Anne E Boyer +11 more
doaj +1 more source
Bacillus anthracis Edema Toxin Activates Nuclear Glycogen Synthase Kinase 3β [PDF]
Infection and Immunity, 2008 ABSTRACT Bacillus anthracis edema toxin (ET) generates high levels of cyclic AMP and impacts a complex network of signaling pathways in targeted cells. In the current study, we sought to identify kinase signaling pathways modulated by ET to better understand how this toxin alters cell physiology.
Jason L, Larabee +3 more
openaire +2 more sources
Toxins, 2011 Outbreaks of Bacillus anthracis in the US and Europe over the past 10 years have emphasized the health threat this lethal bacteria poses even for developed parts of the world.
Peter Q. Eichacker +5 more
doaj +1 more source
Toxins, 2021 Heat-labile toxin I (LT-I), produced by strains of enterotoxigenic Escherichia coli (ETEC), causes profuse watery diarrhea in humans. Different in vitro and in vivo models have already elucidated the mechanism of action of this toxin; however, their use ...
Camila Henrique +8 more
doaj +1 more source
Globotetraosylceramide Is Recognized by the Pig Edema Disease Toxin
Journal of Biological Chemistry, 1989 The pig edema disease toxin has been shown by a tlc glycolipid binding assay to bind specifically to globotetraosylceramide (Gb4, GalNAc beta 1-3Gal alpha 1-4Gal beta 1-4GlcCer.). Binding was reduced for globotriosylceramide (Gb3, Gal alpha 1-4Gal beta 1-4GlcCer) and more markedly for the Forssman antigen (GalNAc alpha 1-3GalNAc beta 1-3Gal alpha 1 ...
S, DeGrandis +4 more
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Anthrax Edema Toxin Inhibits Endothelial Cell Chemotaxis via Epac and Rap1 [PDF]
Journal of Biological Chemistry, 2007 Angiogenesis involves the assembly of endothelial cells into capillaries from a pre-existing vasculature. Because abnormal angiogenesis is a hallmark of many cancers, it is critical to find factors that control this process. Endothelial cells are enriched in the anthrax receptor; we therefore determined the effect of anthrax edema toxin (ET), an ...
Jia, Hong +5 more
openaire +2 more sources
PLoS ONE, 2010 BackgroundAnthrax toxin is comprised of protective antigen (PA), lethal factor (LF), and edema factor (EF). These proteins are individually nontoxic; however, when PA assembles with LF and EF, it produces lethal toxin and edema toxin, respectively ...
Alexander F Kintzer +4 more
doaj +1 more source