Results 41 to 50 of about 33,099 (254)

Experimental study on the effect of toxin fractions isolated from hydatid cyst fluid of sheep on the cardiac muscles of mice [PDF]

Iraqi Journal of Veterinary Sciences, 2021
The aim of this study was to investigate the effectiveness of hydatid cyst toxin fractions in mice. Fifty male mice were divided into five groups with 10 mice for each group the first group as control the second group was injected with toxin fractions at
Hana Kh. Ismail, Ilham A. AL-Saleem, Afrah Y. Jasim   +2 more
doaj   +1 more source

Quantitative Mass Spectrometry for Bacterial Protein Toxins — A Sensitive, Specific, High-Throughput Tool for Detection and Diagnosis

Molecules, 2011
Matrix-assisted laser-desorption time-of-flight (MALDI-TOF) mass spectrometry (MS) is a valuable high-throughput tool for peptide analysis. Liquid chromatography electrospray ionization (LC-ESI) tandem-MS provides sensitive and specific quantification of
Suzanne Kalb, Conrad P. Quinn, John R. Barr, Hercules Moura, Renato C. Lins, Zsuzsanna Kuklenyik, Adrian Woolfitt, Maribel Gallegos-Candela, Anne E. Boyer   +8 more
doaj   +1 more source

A Review of the Efficacy of FDA-Approved B. anthracis Anti-Toxin Agents When Combined with Antibiotic or Hemodynamic Support in Infection- or Toxin-Challenged Preclinical Models

Toxins, 2021
Anti-toxin agents for severe B. anthracis infection will only be effective if they add to the benefit of the two mainstays of septic shock management, antibiotic therapy and titrated hemodynamic support.
Zoe Couse, Xizhong Cui, Yan Li, Mahtab Moayeri, Stephen Leppla, Peter Q. Eichacker   +5 more
doaj   +1 more source

The Potential Pathogenic Contributions of Endothelial Barrier and Arterial Contractile Dysfunction to Shock Due to B. anthracis Lethal and Edema Toxins

Toxins, 2017
Shock with B. anthracis infection is particularly resistant to conventional cardiovascular support and its mortality rate appears higher than with more common bacterial pathogens.
Dante A. Suffredini, Xizhong Cui, Wanying Xu, Yan Li, Peter Q. Eichacker   +4 more
doaj   +1 more source

Lung endothelial cells are sensitive to epsilon toxin from Clostridium perfringens

Veterinary Research, 2020
The pore-forming protein epsilon toxin (Etx) from Clostridium perfringens produces acute perivascular edema affecting several organs, especially the brain and lungs.
Jonatan Dorca-Arévalo, Eduard Dorca, Benjamín Torrejón-Escribano, Marta Blanch, Mireia Martín-Satué, Juan Blasi   +5 more
doaj   +1 more source

Cytoskeleton as an Emerging Target of Anthrax Toxins

Toxins, 2012
Bacillus anthracis, the agent of anthrax, has gained virulence through its exotoxins produced by vegetative bacilli and is composed of three components forming lethal toxin (LT) and edema toxin (ET).
Jean-Nicolas Tournier, Yannick Trescos
doaj   +1 more source

What Is Anthrax?

Pathogens, 2022
Anthrax has been feared for its high mortality in animals and humans for centuries. The etiologic agent is considered a potentially devastating bioweapon, and since 1876―when Robert Koch demonstrated that Bacillus anthracis caused anthrax―it has been ...
William A. Bower, Katherine A. Hendricks, Antonio R. Vieira, Rita M. Traxler, Zachary Weiner, Ruth Lynfield, Alex Hoffmaster   +6 more
doaj   +1 more source

Shiga toxin 2 from enterohemorrhagic Escherichia coli induces reactive glial cells and neurovascular disarrangements including edema and lipid peroxidation in the murine brain hippocampus

Journal of Biomedical Science, 2019
Background Shiga toxin 2 from enterohemorrhagic Escherichia coli is the etiologic agent of bloody diarrhea, hemolytic uremic syndrome and derived encephalopathies that may result to death in patients.
Clara Berdasco, Alipio Pinto, Valeria Calabró, David Arenas, Adriana Cangelosi, Patricia Geoghegan, Pablo Evelson, Jorge Goldstein   +7 more
doaj   +1 more source

Anthrax toxin translocation complex reveals insight into the lethal factor unfolding and refolding mechanism

Scientific Reports, 2021
Translocation is essential to the anthrax toxin mechanism. Protective antigen (PA), the binding component of this AB toxin, forms an oligomeric pore that translocates lethal factor (LF) or edema factor, the active components of the toxin, into the cell ...
Alexandra J. Machen, Mark T. Fisher, Bret D. Freudenthal   +2 more
doaj   +1 more source

Rapidly improving acute myocarditis after a scorpion sting

Türk Kardiyoloji Derneği Arşivi, 2013
Scorpion stings are usually benign, but especially cardiovascular death has been reported due to complications. Local reactions at the site of the sting as well as organ dysfunction may be due to the effects of a systemic toxin.
Nermin Bayar, Selçuk Küçükseymen, İsa Öner Yüksel, Şakir Arslan   +3 more
doaj   +1 more source