Results 1 to 10 of about 219,147 (181)
T-Bet and Eomes Regulate the Balance between the Effector/Central Memory T Cells versus Memory Stem Like T Cells. [PDF]
PLoS ONE, 2013 Memory T cells are composed of effector, central, and memory stem cells. Previous studies have implicated that both T-bet and Eomes are involved in the generation of effector and central memory CD8 T cells.
Gang Li +6 more
doaj +14 more sources
G-Protein Coupled Receptor 18 Contributes to Establishment of the CD8 Effector T Cell Compartment [PDF]
Frontiers in Immunology, 2018 The requirements for effector and memory CD8 T cell development are incompletely understood. Recent work has revealed a role for G-protein coupled receptor 18 (GPR18) in establishment of the intestinal CD8αα intraepithelial lymphocyte compartment.
Hayakazu Sumida, Jason G. Cyster
doaj +14 more sources
Down-Regulation of Surface CD28 under Belatacept Treatment: An Escape Mechanism for Antigen-Reactive T-Cells. [PDF]
PLoS ONE, 2016 BACKGROUND:The co-stimulatory inhibitor of the CD28-CD80/86-pathway, belatacept, allows calcineurin-inhibitor-free immunosuppression in kidney transplantation.
Gretchen N de Graav +5 more
doaj +7 more sources
Molecular signatures distinguish human central memory from effector memory CD8 T cell subsets [PDF]
The Journal of Immunology, 2005 Memory T cells are heterogeneous in terms of their phenotype and functional properties. We investigated the molecular profiles of human CD8 naive central memory (TCM), effector memory (TEM), and effector memory RA (TEMRA) T cells using gene expression ...
Callan, Margaret F C +4 more
core +5 more sources
Cytomegalovirus infection and progressive differentiation of effector-memory T cells. [PDF]
F1000Res, 2018 Primary cytomegalovirus (CMV) infection leads to strong innate and adaptive immune responses against the virus, which prevents serious disease. However, CMV infection can cause serious morbidity and mortality in individuals who are immunocompromised.
Pardieck IN +3 more
europepmc +4 more sources
Frontiers in Immunology, 2021 Effective T cell differentiation during acute virus infections leads to the generation of effector T cells that mediate viral clearance, as well as memory T cells that confer protection against subsequent reinfection.
Roberto Tinoco +4 more
doaj +1 more source
SnapShot: Effector and Memory T Cell Differentiation [PDF]
Journal of End-to-End-testing, 2009 The differentiation of T cells is an ideal system to study the molecular basis of lineage specification in mammalian cells. Upon stimulation with antigen during infection or inflammation, naive peripheral T cells differentiate into various types of effector T cells with specific immune functions.
Pipkin, Matthew E., Rao, Anjana
openaire +2 more sources
Frontiers in Immunology, 2021 CD4−CD8− (double-negative, DN) T cells are critical orchestrators of the cytokine network associated with the pathogenic inflammatory response in one of the deadliest cardiomyopathies known, Chagas heart disease, which is caused by Trypanosoma cruzi ...
Livia Silva Araújo Passos +10 more
doaj +1 more source
Rapid Effector Function in CD8+ Memory T Cells [PDF]
The Journal of Experimental Medicine, 1997 The nature of the CD8+ T cells that underlie antiviral protective immunological memory in vivo is unclear. We have characterized peptide-specific CD8+ T lymphocytes directly ex vivo from peripheral blood in humans with past exposure to influenza virus, using single cell interferon γ (IFN-γ) release as a measure of effector function.
Lalvani, A +5 more
openaire +3 more sources
Mitochondrial Dysfunction in CD4+ T Effector Memory RA+ Cells
Biology, 2023 Human ageing is accompanied by poor responses to infection and decreased vaccine efficacy. While the causes of this can be attributed to defects in the immune system that increase with age, it is unknown whether mitochondrial dysfunction may also contribute to these phenomena.
Marie Strickland +9 more
openaire +5 more sources