Results 31 to 40 of about 219,266 (297)

T-Bet+ IgM Memory Cells Generate Multi-lineage Effector B Cells [PDF]

Cell Reports, 2018
Immunoglobulin M (IgM) memory cells undergo differentiation in germinal centers following antigen challenge, but the full effector cell potential of these cells is unknown. We monitored the differentiation of enhanced yellow fluorescent protein (eYFP)-labeled CD11c+ and CD11cneg T-bet+ IgM memory cells after their transfer into naive recipient mice ...
Kenderes, Kevin J., Levack, Russell C., Papillion, Amber M., Cabrera-Martinez, Berenice, Dishaw, Lisa M., Winslow, Gary M.   +5 more
openaire   +2 more sources

Effector memory Th1 CD4 T cells are maintained in a mouse model of chronic malaria.

PLoS Pathogens, 2010
Protection against malaria often decays in the absence of infection, suggesting that protective immunological memory depends on stimulation. Here we have used CD4(+) T cells from a transgenic mouse carrying a T cell receptor specific for a malaria ...
Robin Stephens, Jean Langhorne
doaj   +1 more source

Altered T cell memory and effector cell development in chronic lymphatic filarial infection that is independent of persistent parasite antigen. [PDF]

PLoS ONE, 2011
Chronic lymphatic filarial (LF) infection is associated with suppression of parasite-specific T cell responses that persist even following elimination of infection.
Cathy Steel, Thomas B Nutman
doaj   +1 more source

Early Decision: Effector and Effector Memory T Cell Differentiation in Chronic Infection [PDF]

Current Immunology Reviews, 2014
As effector memory T cells (Tem) are the predominant population elicited by chronic parasitic infections, increasing our knowledge of their function, survival and derivation, as phenotypically and functionally distinct from central memory and effector T cells will be critical to vaccine development for these diseases. In some infections, memory T cells
Opata, Michael M., Stephens, Robin
openaire   +2 more sources

Peroxiredoxin II Regulates Effector and Secondary Memory CD8+ T cell Responses [PDF]

, 2012
Reactive oxygen intermediates (ROI) generated in response to receptor stimulation play an important role in cellular responses. However, the effect of increased H2O2on an antigen-specific CD8+ T cell response was unknown.
A. E. Weant, Abate, Ahmed, Alexander-Miller, Barber, Blackburn, Case, Cayota, Chae, Chaudhri, Choi, Chung, Cui, D. G. Juneau, D.-Y. Yu, Das, Devadas, E. M. Hiltbold, E.-Y. Moon, Gopalakrishna, Grayson, Grayson, Hockenbery, Ichii, Imboden, Intlekofer, J. M. Grayson, Jabbari, Jonsson, Joshi, K. E. Crump, Kusmartsev, Kwon, L. B. Poole, Laniewski, Lee, Low, Matthews, May, Meng, Michalek, Moon, Murali-Krishna, Murali-Krishna, Mustelin, Nishi, Pearce, Perl, Piganelli, R. D. Michalek, Rutishauser, Shlomai, Tebo, Wherry, Wood, Wood, Xanthoudakis, Yang, Yang, Yi, Zenewicz, Zhang   +61 more
core   +2 more sources

Death of effector memory T cells characterizes AIDS

Frontiers in Bioscience, 2009
The adaptive effector CD4+ T helper-mediated immune response is highly heterogeneous, based on the development of distinct subsets that are characterized by the expression of different profiles of cell surface markers. Functional impairment of T cells is characteristic of many chronic mouse and human viral infections.
Laforge, Mireille, Senik, Anna, Cumont, Marie-Christine, Monceaux, Valerie, Hurtrel, Bruno, Estaquier, Jerome   +5 more
openaire   +2 more sources

Sustained Id2 regulation of E proteins is required for terminal differentiation of effector CD8+ T cells. [PDF]

, 2018
CD8+ T cells responding to infection differentiate into a heterogeneous population composed of progeny that are short-lived and participate in the immediate, acute response and those that provide long-lasting host protection.
Goldrath, Ananda W, Milner, J Justin, Nadjsombati, Marija S, Omilusik, Kyla D, Shaw, Laura A, Yu, Bingfei   +5 more
core   +1 more source

Effector memory differentiation increases detection of replication-competent HIV-l in resting CD4+ T cells from virally suppressed individuals. [PDF]

, 2019
Studies have demonstrated that intensive ART alone is not capable of eradicating HIV-1, as the virus rebounds within a few weeks upon treatment interruption.
Bale, Michael J, Busch, Michael P, Cox, Bryan, Deeks, Steven G, Hoh, Rebecca, Kearney, Mary F, Kulpa, Deanna A, Lackman-Smith, Carol, Maldarelli, Frank, Ptak, Roger G, Stone, Mars, Subramanian, Krupa, Wiegand, Ann, Wonderlich, Elizabeth R   +13 more
core   +1 more source

CD8+ T Effector Memory Cells Protect against Liver-Stage Malaria [PDF]

The Journal of Immunology, 2011
Abstract Identification of correlates of protection for infectious diseases including malaria is a major challenge and has become one of the main obstacles in developing effective vaccines. We investigated protection against liver-stage malaria conferred by vaccination with adenoviral (Ad) and modified vaccinia Ankara (MVA) vectors ...
Reyes-Sandoval, A, Wyllie, D, Bauza, K, Milicic, A, Forbes, E, Rollier, C, Hill, A   +6 more
openaire   +3 more sources

Chronic parasitic infection maintains high frequencies of short-lived Ly6C+CD4+ effector T cells that are required for protection against re-infection. [PDF]

PLoS Pathogens, 2014
In contrast to the ability of long-lived CD8(+) memory T cells to mediate protection against systemic viral infections, the relationship between CD4(+) T cell memory and acquired resistance against infectious pathogens remains poorly defined.
Nathan C Peters, Antonio J Pagán, Phillip G Lawyer, Timothy W Hand, Eric Henrique Roma, Lisa W Stamper, Audrey Romano, David L Sacks   +7 more
doaj   +1 more source