Results 21 to 30 of about 167,075 (204)

Ever-Adapting RND Efflux Pumps in Gram-Negative Multidrug-Resistant Pathogens: A Race against Time

Antibiotics, 2021
The rise in multidrug resistance (MDR) is one of the greatest threats to human health worldwide. MDR in bacterial pathogens is a major challenge in healthcare, as bacterial infections are becoming untreatable by commercially available antibiotics. One of
Martijn Zwama, Kunihiko Nishino
doaj   +1 more source

Antimicrobial and Efflux Pump Inhibitory Activity of Caffeoylquinic Acids from Artemisia absinthium against Gram-Positive Pathogenic Bacteria [PDF]

, 2010
Background: Traditional antibiotics are increasingly suffering from the emergence of multidrug resistance amongst pathogenic bacteria leading to a range of novel approaches to control microbial infections being investigated as potential alternative ...
Han Haley, Jacques Vervoort, Alexandre M. J. J. Bonvin, George P Tegos, Lewis Kim, Panagiotis L. Kastritis, Vervoort, J., NMR Spectroscopy, Michael R. Hamblin, Kastritis, P., Vervoort Jacques, Exarchou, Vassiliki, Vervoort, Jacques, Bonvin, A.M., Kastritis Panagiotis L., Hamblin, Michael, Tegos, George, Tegos, George P., Lewis, K., Kim Lewis, George P. Tegos, Bonvin, Alexandre M. J. J., Panagiotis L Kastritis, Bonvin Alexandre M. J. J., Sub NMR Spectroscopy, Han, H., Tegos, G.P., Alexandre M J J Bonvin, Fiamegos Yiannis C., Fiamegos, Y.C., Yiannis C Fiamegos, Kastritis, P.L., Hamblin, Michael R., Exarchou Vassiliki, Lewis, Kim, Exarchou, V., Han, Haley, Hamblin Michael R., Tegos George P., Michael R Hamblin, Fiamegos, Yiannis C., Haley Han, Yiannis C. Fiamegos, Kastritis, Panagiotis L., Vassiliki Exarchou, Bonvin, A.M.J.J., Hamblin, M.R., Vervoort, J.J.M.   +47 more
core   +2 more sources

Nanoparticles as Efflux Pump and Biofilm Inhibitor to Rejuvenate Bactericidal Effect of Conventional Antibiotics

Nanoscale Research Letters, 2017
The universal problem of bacterial resistance to antibiotic reflects a serious threat for physicians to control infections. Evolution in bacteria results in the development of various complex resistance mechanisms to neutralize the bactericidal effect of
Divya Gupta, Ajeet Singh, Asad U. Khan
doaj   +1 more source

Evaluation of Delafloxacin against a Burkholderia pseudomallei Efflux Mutant Panel

Microbiology Spectrum, 2022
In vitro activities of delafloxacin and ciprofloxacin were evaluated against Burkholderia pseudomallei mutants expressing or lacking defined resistance-nodulation-cell division (RND) efflux pumps using CLSI methodology at pHs of 5.8 and 7.2. Delafloxacin
Sandra P. McCurdy, Nawarat Somprasong, Herbert P. Schweizer   +2 more
doaj   +1 more source

Combination Therapy with Ciprofloxacin and Pentamidine against Multidrug-Resistant Pseudomonas aeruginosa: Assessment of In Vitro and In Vivo Efficacy and the Role of Resistance–Nodulation–Division (RND) Efflux Pumps

Antibiotics, 2023
The aim of this work was to (i) evaluate the efficacy of a combination treatment of pentamidine with ciprofloxacin against Galleria mellonella larvae infected with an MDR strain of P.
Megan Fletcher, Alex McCormack, Benjamin J. Parcell, Peter J. Coote   +3 more
doaj   +1 more source

Role of efflux pumps in reduced susceptibility to tigecycline in Acinetobacter baumannii

New Microbes and New Infections, 2019
Acinetobacter baumannii is an important human pathogen responsible for a various type of infections. These bacterial strains are generally resistant to numerous antibiotics.
S.H. Ardehali, T. Azimi, Fatemeh Fallah, M. Owrang, N. Aghamohammadi, L. Azimi   +5 more
doaj   +1 more source

The Role of Efflux Pumps in the Transition from Low-Level to Clinical Antibiotic Resistance

Antibiotics, 2020
Antibiotic resistance is on the rise and has become one of the biggest public health challenges of our time. Bacteria are able to adapt to the selective pressure exerted by antibiotics in numerous ways, including the (over)expression of efflux pumps ...
Anna Elisabeth Ebbensgaard, Anders Løbner-Olesen, Jakob Frimodt-Møller   +2 more
doaj   +1 more source

An ace up their sleeve: a transcriptomic approach exposes the AceI efflux protein of Acinetobacter baumannii and reveals the drug efflux potential hidden in many microbial pathogens

Frontiers in Microbiology, 2015
The era of antibiotics as a cure-all for bacterial infections appears to be coming to an end. The emergence of multidrug resistance in many hospital-associated pathogens has resulted in superbugs that are effectively untreatable.
Karl A Hassan, Liam DH Elbourne, Liping eLi, Hasinika KA Hewawasam Gamage, Qi eLiu, Scott M Jackson, David eSharples, Anne-Brit eKolstø, Peter JF Henderson, Ian T Paulsen   +9 more
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Roles of SmeYZ, SbiAB, and SmeDEF Efflux Systems in Iron Homeostasis of Stenotrophomonas maltophilia

Microbiology Spectrum, 2022
Stenotrophomonas maltophilia, a nonfermenting Gram-negative rod, is frequently isolated from the environment and is emerging as a multidrug-resistant global opportunistic pathogen. S.
Chao-Jung Wu, Yu Chen, Li-Hua Li, Cheng-Mu Wu, Yi-Tsung Lin, Cheng-Hua Ma, Tsuey-Ching Yang   +6 more
doaj   +1 more source

Role of bacterial efflux pumps in biofilm formation [PDF]

, 2018
Efflux pumps are widely implicated in antibiotic resistance because they can extrude the majority of clinically relevant antibiotics from within cells to the extracellular environment.
Rahman, Khondaker Miraz, Ilyas Alav, J Mark Sutton, Rahman, Khondaker Miraz; id_orcid, Sutton, J. Mark, Alav, Ilyas; id_orcid, Khondaker Miraz Rahman, Sutton, J Mark, Alav, Ilyas   +8 more
core   +1 more source