Results 31 to 40 of about 167,075 (204)
Investigating the Escherichia coli Drug Efflux System: Generation of an Efflux Deficient Genetic Background [PDF]
, 2021 The Escherichia coli drug efflux network is expansive and complex, encompassing 37 efflux pump encoding genes. Several efflux pumps, such as the AcrAB-TolC complex, display promiscuous substrate specificities, which contributes significantly to ...
Teelucksingh, Tanisha
core +1 more source
Development of Nucleic Acid Aptamers to Inhibit Bacterial Efflux Pumps [PDF]
, 2021 Multidrug resistance in bacteria, defined as the ability of a bacterial strain to resist the killing effects of more than one antibiotic, represents a major threat to global healthcare.
Moses, Emilie A.
core +1 more source
Efflux pumps as potential targets for biofilm inhibition
Frontiers in MicrobiologyBiofilms account for a great deal of infectious diseases and contribute significantly to antimicrobial resistance. Efflux pumps confer antimicrobial resistance to microorganisms and involve multiple processes of biofilm formation. Efflux pump inhibitors (
Jingyi Ren +3 more
doaj +1 more source
Vibrio cholerae VexH encodes a multiple drug efflux pump that contributes to the production of cholera toxin and the toxin co-regulated pilus. [PDF]
PLoS ONE, 2012 The resistance-nodulation-division (RND) efflux systems are ubiquitous transporters that function in antimicrobial resistance. Recent studies showed that RND systems were required for virulence factor production in Vibrio cholerae. The V. cholerae genome
Dawn L Taylor +2 more
doaj +1 more source
mBio, 2016 Multidrug efflux pumps provide clinically significant levels of drug resistance in a number of Gram-negative hospital-acquired pathogens. These pathogens frequently carry dozens of genes encoding putative multidrug efflux pumps.
Karl A. Hassan +13 more
doaj +1 more source
Coincidence analysis of efflux pumps in the Escherichia coli pangenome
, 2023 Global rates of multi-drug resistance continue to rise, posing a significant challenge in the fight against antimicrobial resistance worldwide. Multi-drug efflux pumps are a significant contributor to this burden.
Shahabuddin, Ammar A. +2 more
core +1 more source
FEBS Letters, EarlyView.Heterodimeric amino acid transporters consist of SLC7 and SLC3 family proteins arranged in a conserved structural organization. They regulate nutrient transport across cell membranes, supporting essential cellular functions. These transporters also contribute to xenobiotic/drug uptake and distribution.
Mariafrancesca Scalise +5 more
wiley +1 more source
Elucidation of the structure and molecular mechanism of the tripartite multidrug efflux pumps in the Gram-negative pathogens: Vibrio cholerae and Neisseria gonorrhoeae [PDF]
, 2006 In bacteria, multidrug efflux systems have been identified as significant determinants of resistance recently. These resistance pumps are widely distributed in bacterial species and many pathogenic bacteria posses them, which play an important role in ...
Du, Dijun
core
Genomic Tools to Investigate Bacterial Drug Efflux Pumps [PDF]
New therapeutics are urgently needed to combat Gram-negative pathogens such as Escherichia coli, yet antibiotic development has been significantly hindered due to intrinsic antimicrobial resistance elements such as efflux pumps. E. coli harbours 35 known
Thompson, Laura
core +1 more source
Molecular Oncology, EarlyView.The novel styrylquinazolinone‐based molecule W1B effectively suppresses glioblastoma by inhibiting IGF1R and EGFR. In high‐glucose microenvironments driving tumor resistance, W1B acts synergistically with the EGFR inhibitor dacomitinib. This combination safely blocks compensatory survival signaling in zebrafish xenograft models. Showcasing promising in
Patryk Rurka +9 more
wiley +1 more source