Results 21 to 30 of about 90,161 (342)
mSystems, 2021 Multidrug resistance (MDR) efflux pumps are involved in bacterial intrinsic resistance to multiple antimicrobials. Expression of MDR efflux pumps can be either constitutive or transiently induced by various environmental signals, which are typically ...
Di-Yin Li +7 more
doaj +1 more source
Ever-Adapting RND Efflux Pumps in Gram-Negative Multidrug-Resistant Pathogens: A Race against Time
Antibiotics, 2021 The rise in multidrug resistance (MDR) is one of the greatest threats to human health worldwide. MDR in bacterial pathogens is a major challenge in healthcare, as bacterial infections are becoming untreatable by commercially available antibiotics. One of
Martijn Zwama, Kunihiko Nishino
doaj +1 more source
Evaluation of Delafloxacin against a Burkholderia pseudomallei Efflux Mutant Panel
Microbiology Spectrum, 2022 In vitro activities of delafloxacin and ciprofloxacin were evaluated against Burkholderia pseudomallei mutants expressing or lacking defined resistance-nodulation-cell division (RND) efflux pumps using CLSI methodology at pHs of 5.8 and 7.2. Delafloxacin
Sandra P. McCurdy +2 more
doaj +1 more source
Effect of efflux pump inhibition on Pseudomonas aeruginosa transcriptome and virulence [PDF]
, 2017 Efflux pumps of the resistance-nodulation-cell-division (RND) family increase antibiotic resistance in many bacterial pathogens, representing candidate targets for the development of antibiotic adjuvants.
Baldelli, Valerio +8 more
core +2 more sources
Nanoscale Research Letters, 2017 The universal problem of bacterial resistance to antibiotic reflects a serious threat for physicians to control infections. Evolution in bacteria results in the development of various complex resistance mechanisms to neutralize the bactericidal effect of
Divya Gupta, Ajeet Singh, Asad U. Khan
doaj +1 more source
Antibiotics, 2023 The aim of this work was to (i) evaluate the efficacy of a combination treatment of pentamidine with ciprofloxacin against Galleria mellonella larvae infected with an MDR strain of P.
Megan Fletcher +3 more
doaj +1 more source
Bacterial Multidrug Efflux Pumps: Much More Than Antibiotic Resistance Determinants
Microorganisms, 2016 Bacterial multidrug efflux pumps are antibiotic resistance determinants present in all microorganisms. With few exceptions, they are chromosomally encoded and present a conserved organization both at the genetic and at the protein levels.
Paula Blanco +8 more
doaj +1 more source
Genome-Wide Transposon Screen of a Pseudomonas syringae mexB Mutant Reveals the Substrates of Efflux Transporters. [PDF]
, 2019 Bacteria express numerous efflux transporters that confer resistance to diverse toxicants present in their environment. Due to a high level of functional redundancy of these transporters, it is difficult to identify those that are of most importance in ...
Deutschbauer, Adam M +4 more
core +1 more source
Versatility of Stenotrophomonas maltophilia: Ecological roles of RND efflux pumps
Heliyon, 2023 S. maltophilia is a widely distributed bacterium found in natural, anthropized and clinical environments. The genome of this opportunistic pathogen of environmental origin includes a large number of genes encoding RND efflux pumps independently of the ...
Amandine Chauviat +2 more
doaj +1 more source
Molecular mechanism of MBX2319 inhibition of Escherichia coli AcrB multidrug efflux pump and comparison with other inhibitors [PDF]
, 2014 Efflux pumps of the resistance nodulation division (RND) superfamily, such as AcrB, make a major contribution to multidrug resistance in Gram-negative bacteria. The development of inhibitors of the RND pumps would improve the efficacy of current and next-
Nguyen, ST +4 more
core +2 more sources