Results 51 to 60 of about 90,161 (342)

Fluorescence-Based Flow Sorting in Parallel with Transposon Insertion Site Sequencing Identifies Multidrug Efflux Systems in Acinetobacter baumannii

mBio, 2016
Multidrug efflux pumps provide clinically significant levels of drug resistance in a number of Gram-negative hospital-acquired pathogens. These pathogens frequently carry dozens of genes encoding putative multidrug efflux pumps.
Karl A. Hassan, Amy K. Cain, TaoTao Huang, Qi Liu, Liam D. H. Elbourne, Christine J. Boinett, Anthony J. Brzoska, Liping Li, Martin Ostrowski, Nguyen Thi Khanh Nhu, Tran Do Hoang Nhu, Stephen Baker, Julian Parkhill, Ian T. Paulsen   +13 more
doaj   +1 more source

Determination of efflux activity in Enterococci by Hoechst accumulation assay and the role of zinc oxide nanoparticles in inhibition of this activity

BMC Microbiology, 2022
Background Contribution of efflux pumps in development of antimicrobial resistance has been largely addressed in Gram negative and to a much lesser extent in Gram positive bacteria.
Mohammad Hossein Sobhanipoor, Roya Ahmadrajabi, Hossein Hosseini Nave, Fereshteh Saffari   +3 more
doaj   +1 more source

Social interactions in the Burkholderia cepacia complex : biofilms and quorum sensing [PDF]

, 2010
Burkholderia cepacia complex bacteria are opportunistic pathogens that cause respiratory tract infections in susceptible patients, mainly people with cystic fibrosis. There is convincing evidence that B.
Coenye, Tom
core   +2 more sources

A P-type ATPase importer that discriminates between essential and toxic transition metals [PDF]

, 2009
Transition metals, although being essential cofactors in many physiological processes, are toxic at elevated concentrations. Among the membrane-embedded transport proteins that maintain appropriate intracellular levels of transition metals are ATP-driven
A. T. Lee, Agranoff, Arguello, Arg  ello, Axelsen, Bal, Bull, D. C. Rees, Finney, Francis, Grass, Johnson, Krogh, Legatzki, Lewinson, Melchers, Nies, O. Lewinson, Papp-Wallace, Phung, Rensing, Schafer, Sharma, Thompson, Trenor, Vulpe   +25 more
core   +2 more sources

Review of: "Inhibiting Efflux Pumps and Resistance Mechanisms: A Mini Review" [PDF]

, 2023
Claus‐Michael Lehr
openalex   +3 more sources

Interplay between three RND efflux pumps in doxycycline-selected strains of Burkholderia thailandensis. [PDF]

PLoS ONE, 2013
BACKGROUND: Efflux systems are involved in multidrug resistance in most Gram-negative non-fermentative bacteria. We have chosen Burkholderia thailandensis to dissect the development of multidrug resistance phenotypes under antibiotic pressure ...
Fabrice Vincent Biot, Mélanie Monique Lopez, Thomas Poyot, Fabienne Neulat-Ripoll, Sabrina Lignon, Arnaud Caclard, François Michel Thibault, Andre Peinnequin, Jean-Marie Pagès, Eric Valade   +9 more
doaj   +1 more source

Contribution of RND-Type Efflux Pumps in Reduced Susceptibility to Biocides in Acinetobacter baumannii

Antibiotics, 2022
Bacterial efflux pumps are among the key mechanisms of resistance against antibiotics and biocides. We investigated whether differential expression levels of the RND-type efflux pumps AdeABC and AdeIJK impacted the susceptibility to commonly used ...
Christina Meyer, Kai Lucaβen, Stefanie Gerson, Kyriaki Xanthopoulou, Thorsten Wille, Harald Seifert, Paul G. Higgins   +6 more
doaj   +1 more source

Effect of β-lactamase inhibitors on in vitro activity of β-lactam antibiotics against Burkholderia cepacia complex species [PDF]

, 2016
Background: Bacteria belonging to the Burkholderia cepacia complex (Bcc) are an important cause of chronic respiratory tract infections in cystic fibrosis patients. Intrinsic resistance to a wide range of antimicrobial agents, including a variety of beta-
Coenye, Tom, Everaert, Annelien
core   +2 more sources

Substrate specificity of Burkholderia pseudomallei multidrug transporters is influenced by the hydrophilic patch in the substrate‐binding pocket

FEBS Letters, EarlyView.
Multidrug transporters BpeB and BpeF from the Gram‐negative pathogen Burkholderia pseudomallei have a hydrophilic patch in their substrate‐binding pocket. Drug susceptibility tests and growth curve analyses using an Escherichia coli recombinant expression system revealed that the hydrophilic patches of BpeB and BpeF are involved in the substrate ...
Ui Okada, Satoshi Murakami
wiley   +1 more source

Efflux Pump-mediated Drug Resistance in Burkholderia

Frontiers in Microbiology, 2015
Several members of the genus Burkholderia are prominent pathogens. Infections caused by these bacteria are difficult to treat because of significant antibiotic resistance.
Nicole L Podnecky, Katherine A Rhodes, Katherine A Rhodes, Herbert P Schweizer, Herbert P Schweizer   +4 more
doaj   +1 more source