Results 1 to 10 of about 39,327 (264)

Eicosanoid release is increased by membrane destabilization and CFTR inhibition in Calu-3 cells. [PDF]

PLoS ONE, 2009
The antiinflammatory protein annexin-1 (ANXA1) and the adaptor S100A10 (p11), inhibit cytosolic phospholipase A2 (cPLA2alpha) by direct interaction. Since the latter is responsible for the cleavage of arachidonic acid at membrane phospholipids, all three
Florence Borot, Diane-Lore Vieu, Grazyna Faure, Janine Fritsch, Julien Colas, Sandra Moriceau, Maryvonne Baudouin-Legros, Franck Brouillard, Jesus Ayala-Sanmartin, Lhousseine Touqui, Marc Chanson, Aleksander Edelman, Mario Ollero   +12 more
doaj   +3 more sources

Red blood cell transfusion-related eicosanoid profiles in intensive care patients—A prospective, observational feasibility study

Frontiers in Physiology, 2023
Introduction: Eicosanoids are bioactive lipids present in packed red blood cells (PRBCs), and might play a role in transfusion-related immunomodulation (TRIM).
Pierre Raeven, Gerhard Hagn, Laura Niederstaetter, Jonas Brugger, Sophia Bayer-Blauensteiner, Christoph Domenig, Konrad Hoetzenecker, Martin Posch, Gerda Leitner, Christopher Gerner, Christopher Gerner, David M. Baron   +11 more
doaj   +1 more source

Deciphering Complex Interactions in Bioactive Lipid Signaling

Molecules, 2023
Lipids are usually viewed as metabolic fuel and structural membrane components. Yet, in recent years, different families of lipids able to act as authentic messengers between cells and/or intracellularly have been discovered. Such lipid signals have been
Mauro Maccarrone
doaj   +1 more source

Dorsal switch protein 1 as a damage signal in insect gut immunity to activate dual oxidase via an eicosanoid, PGE2

Frontiers in Immunology, 2022
Various microbiota including beneficial symbionts reside in the insect gut. Infections of pathogens cause dysregulation of the microflora and threaten insect survival. Reactive oxygen species (ROS) have been used in the gut immune responses, in which its
Miltan Chandra Roy, Shabbir Ahmed, Yonggyun Kim   +2 more
doaj   +1 more source

Plasma Oxylipins and Their Precursors Are Strongly Associated with COVID-19 Severity and with Immune Response Markers

Metabolites, 2022
COVID-19 is characterised by a dysregulated immune response, that involves signalling lipids acting as mediators of the inflammatory process along the innate and adaptive phases.
Naama Karu, Alida Kindt, Lieke Lamont, Adriaan J. van Gammeren, Anton A. M. Ermens, Amy C. Harms, Lutzen Portengen, Roel C. H. Vermeulen, Willem A. Dik, Anton W. Langerak, Vincent H. J. van der Velden, Thomas Hankemeier   +11 more
doaj   +1 more source

Characterization of eicosanoid synthesis in a genetic ablation model of ceramide kinase[S]

Journal of Lipid Research, 2013
Multiple reports have demonstrated a role for ceramide kinase (CERK) in the production of eicosanoids. To examine the effects of the genetic ablation of CERK on eicosanoid synthesis, primary mouse embryonic fibroblasts (MEFs) and macrophages were ...
Jennifer A. Mietla, Dayanjan S. Wijesinghe, L. Alexis Hoeferlin, Michael D. Shultz, Ramesh Natarajan, Alpha A. Fowler, III, Charles E. Chalfant   +6 more
doaj   +1 more source

FADS2 function loss at the cancer hotspot 11q13 locus diverts lipid signaling precursor synthesis to unusual eicosanoid fatty acids. [PDF]

PLoS ONE, 2011
BACKGROUND: Genes coding for the fatty acid desaturases (FADS1, 2, 3) localized at the cancer genomic hotspot 11q13 locus are required for the biosynthesis of 20 carbon polyunsaturated fatty acids (PUFA) that are direct eicosanoid precursors.
Woo Jung Park, Kumar S D Kothapalli, Peter Lawrence, J Thomas Brenna   +3 more
doaj   +1 more source

Current Trends and Changes in Use of Membrane Molecular Dynamics Simulations within Academia and the Pharmaceutical Industry

Membranes, 2023
There has been an almost exponential increase in the use of molecular dynamics simulations in basic research and industry over the last 5 years, with almost a doubling in the number of publications each year.
Stephan L. Watkins
doaj   +1 more source

Marked elevations in pro-inflammatory polyunsaturated fatty acid metabolites in females with irritable bowel syndrome

Journal of Lipid Research, 2010
Irritable bowel syndrome (IBS) is the most common functional gastrointestinal disorder referred to gastroenterologists. Although the pathophysiology remains unclear, accumulating evidence points to the presence of low-level immune activation both in the ...
Gerard Clarke, Peter Fitzgerald, Alan A. Hennessy, Eugene M. Cassidy, Eamonn M.M. Quigley, Paul Ross, Catherine Stanton, John F. Cryan, Timothy G. Dinan   +8 more
doaj   +1 more source

A genome-wide association study identifies 41 loci associated with eicosanoid levels

Communications Biology, 2023
Eicosanoids are biologically active derivatives of polyunsaturated fatty acids with broad relevance to health and disease. We report a genome-wide association study in 8406 participants of the Atherosclerosis Risk in Communities Study, identifying 41 ...
Eugene P. Rhee, Aditya L. Surapaneni, Pascal Schlosser, Mona Alotaibi, Yueh-ning Yang, Josef Coresh, Mohit Jain, Susan Cheng, Bing Yu, Morgan E. Grams   +9 more
doaj   +1 more source