Results 1 to 10 of about 33,446 (244)

A combined computational strategy of sequence and structural analysis predicts the existence of a functional eicosanoid pathway in Drosophila melanogaster.

PLoS ONE, 2019
This study reports on a putative eicosanoid biosynthesis pathway in Drosophila melanogaster and challenges the currently held view that mechanistic routes to synthesize eicosanoid or eicosanoid-like biolipids do not exist in insects, since to date ...
Michael Scarpati, Yan Qi, Shubha Govind, Shaneen Singh   +3 more
doaj   +2 more sources

Eicosanoid and eicosanoid-related inflammatory mediators and exercise intolerance in heart failure with preserved ejection fraction [PDF]

Nature Communications, 2023
Systemic inflammation has been implicated in the pathobiology of heart failure with preserved ejection fraction (HFpEF). Here, we examine the association of upstream mediators of inflammation as ascertained by fatty-acid derived eicosanoid and eicosanoid-
Emily S. Lau, Athar Roshandelpoor, Shahrooz Zarbafian, Dongyu Wang, James S. Guseh, Norrina Allen, Vinithra Varadarajan, Matthew Nayor, Ravi V. Shah, Joao A. C. Lima, Sanjiv J. Shah, Bing Yu, Mona Alotaibi, Susan Cheng, Mohit Jain, Gregory D. Lewis, Jennifer E. Ho   +16 more
doaj   +2 more sources

The association of eicosanoids and eicosanoid-related metabolites with pulmonary hypertension. [PDF]

Eur Respir J, 2023
BackgroundEicosanoids are bioactive lipids that regulate systemic inflammation and exert vasoactive effects. Specific eicosanoid metabolites have previously been associated with pulmonary hypertension (PH), yet their role remains incompletely understood.MethodsWe studied 482 participants with chronic dyspnoea who underwent clinically indicated ...
McNeill JN, Roshandelpoor A, Alotaibi M, Choudhary A, Jain M, Cheng S, Zarbafian S, Lau ES, Lewis GD, Ho JE.   +9 more
europepmc   +3 more sources

Characterization of eicosanoid synthesis in a genetic ablation model of ceramide kinase[S]

Journal of Lipid Research, 2013
Multiple reports have demonstrated a role for ceramide kinase (CERK) in the production of eicosanoids. To examine the effects of the genetic ablation of CERK on eicosanoid synthesis, primary mouse embryonic fibroblasts (MEFs) and macrophages were ...
Jennifer A. Mietla, Dayanjan S. Wijesinghe, L. Alexis Hoeferlin, Michael D. Shultz, Ramesh Natarajan, Alpha A. Fowler, III, Charles E. Chalfant   +6 more
doaj   +2 more sources

The eicosanoids in biology and medicine

Journal of Lipid Research, 1984
Aaron J. Marcus
openalex   +5 more sources

Mild COVID-19 imprints a long-term inflammatory eicosanoid- and chemokine memory in monocyte-derived macrophages

Mucosal Immunology, 2022
Monocyte-derived macrophages (MDM) drive the inflammatory response to severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) and they are a major source of eicosanoids in airway inflammation.
Sina Bohnacker, F. Hartung, Fiona D. R. Henkel, A. Quaranta, J. Kolmert, Alina Priller, Minhaz Ud-Dean, Johanna Giglberger, Luisa M. Kugler, L. Pechtold, Sarah Yazici, A. Lechner, J. Erber, U. Protzer, P. Lingor, P. Knolle, A. Chaker, C. Schmidt‐Weber, C. Wheelock, Julia Esser-von Bieren   +19 more
semanticscholar   +1 more source

Eicosanoid Signaling in Insect Immunology: New Genes and Unresolved Issues

Genes, 2021
This paper is focused on eicosanoid signaling in insect immunology. We begin with eicosanoid biosynthesis through the actions of phospholipase A2, responsible for hydrolyzing the C18 polyunsaturated fatty acid, linoleic acid (18:2n-6), from cellular ...
Yonggyun Kim, D. Stanley
semanticscholar   +1 more source

Eicosanoid regulation of debris-stimulated metastasis

Proceedings of the National Academy of Sciences of the United States of America, 2021
Significance Cancer therapy, such as chemotherapy, induces tumor cell death (“debris”), which can stimulate metastasis. Chemotherapy-generated debris upregulates soluble epoxide hydrolase (sEH) and the prostaglandin E2 receptor 4 (EP4), which triggers a ...
Jianjun Deng, Haixia Yang, Victoria M. Haak, Jun Yang, F. Kipper, Chantal Barksdale, S. Hwang, Allison Gartung, D. Bielenberg, S. Subbian, Koc-Kan Ho, Xiang Ye, Daidi Fan, Yong-jun Sun, B. Hammock, D. Panigrahy   +15 more
semanticscholar   +1 more source

Dorsal switch protein 1 as a damage signal in insect gut immunity to activate dual oxidase via an eicosanoid, PGE2

Frontiers in Immunology, 2022
Various microbiota including beneficial symbionts reside in the insect gut. Infections of pathogens cause dysregulation of the microflora and threaten insect survival. Reactive oxygen species (ROS) have been used in the gut immune responses, in which its
Miltan Chandra Roy, Shabbir Ahmed, Yonggyun Kim   +2 more
doaj   +1 more source

Plasma Oxylipins and Their Precursors Are Strongly Associated with COVID-19 Severity and with Immune Response Markers

Metabolites, 2022
COVID-19 is characterised by a dysregulated immune response, that involves signalling lipids acting as mediators of the inflammatory process along the innate and adaptive phases.
Naama Karu, Alida Kindt, Lieke Lamont, Adriaan J. van Gammeren, Anton A. M. Ermens, Amy C. Harms, Lutzen Portengen, Roel C. H. Vermeulen, Willem A. Dik, Anton W. Langerak, Vincent H. J. van der Velden, Thomas Hankemeier   +11 more
doaj   +1 more source