Results 91 to 100 of about 33,906 (210)
Diabetes, Obesity and Metabolism, EarlyView.ABSTRACT Excess adiposity and obesity are increasingly prevalent, with incidence rising in many parts of the world; both trigger a state of metabo‐inflammation in adipose tissue, creating a systemic milieu characterised by insulin resistance and pro‐inflammatory and fibrogenic states. Along with systemic inflammatory cues, perturbations in systemic and
Mirjana Grocic +2 more
wiley +1 more source
Cardiac myocyte-specific knock-out of calcium-independent phospholipase A2γ (iPLA2γ) decreases oxidized fatty acids during ischemia/reperfusion and reduces infarct size [PDF]
, 2016 Calcium-independent phospholipase A(2)γ (iPLA(2)γ) is a mitochondrial enzyme that produces lipid second messengers that facilitate opening of the mitochondrial permeability transition pore (mPTP) and contribute to the production of oxidized fatty acids ...
Abendschein, Dana +12 more
core +2 more sources
The FEBS Journal, EarlyView.Ferroptosis is driven by unrestricted peroxidation of polyunsaturated fatty acyl (PUFA) chains in membrane phospholipids. In triple‐negative breast cancer cells, lipid droplets (LDs) sequester dietary PUFAs, limiting their incorporation into membrane phospholipids, preventing mitochondrial damage, and reducing lipid peroxidation and ferroptosis.
Ana Kump +10 more
wiley +1 more source
Evaluation of Cysteinyl Leukotriene Signaling as a Therapeutic Target for Colorectal Cancer
Frontiers in Cell and Developmental Biology, 2016 Colorectal cancer is the third most common cancer worldwide and is associated with significant morbidity and mortality. Current pharmacotherapy options include cytotoxic chemotherapy, anti-VEGF and anti-EGFR targeting drugs, but these are limited by ...
Lorraine Burke +7 more
doaj +1 more source
Polarization of macrophages toward M2 phenotype is favored by reduction in iPLA2β (group VIA phospholipase A2)* [PDF]
, 2016 Macrophages are important in innate and adaptive immunity. Macrophage participation in inflammation or tissue repair is directed by various extracellular signals and mediated by multiple intracellular pathways.
Ashley, Jason W +7 more
core +2 more sources
The FEBS Journal, EarlyView.Fetal growth restriction is associated with placental metabolic adaptations. In small‐for‐gestational‐age placenta (SGA), cholesterol receptors and steroidogenic enzymes are upregulated, enhancing steroidogenesis. NAD salvage pathway is also increased to support NADP+/NADPH requirements.
Serena Xodo +4 more
wiley +1 more source
The FEBS Journal, EarlyView.Using 1H NMR metabolomics, we measured polar and lipid metabolites from human blood neutrophils from people with frailty (n = 31, mean age 84Y), people with rheumatoid arthritis (n = 16, mean age 55Y), robust older (n = 24, mean age 66Y) and healthy younger people (n = 21, mean age 22Y).
Genna Ali Abdullah +5 more
wiley +1 more source
BPTF Enhances Chemotherapy Induced Cytotoxicity [PDF]
, 2020 BPTF Enhances Chemotherapy Induced Cytotoxicity Valentina Posada, Depts. of Biology, Chemistry, & Religious Studies, with Dr. Joseph Landry, Dept. of Human Molecular Genetics New chemotherapies and immunotherapy treatments have greatly improved the ...
Posada, Valentina
core +1 more source
Evaluation of the performance of ChatGPT‐4 and ChatGPT‐4o as a learning tool in endodontics
International Endodontic Journal, EarlyView.Abstract Aims The aim of this study was to evaluate the accuracy and consistency of responses given by two different versions of Chat Generative Pre‐trained Transformer (ChatGPT), ChatGPT‐4, and ChatGPT‐4o, to multiple‐choice questions prepared from undergraduate endodontic education topics at different times of the day and on different days ...
Esra Arılı Öztürk +2 more
wiley +1 more source
Production of inflammatory mediators by human macrophages obtained from ascites [PDF]
, 1994 Ascites is a readily available source of human macrophages (Mø), which can be used to study Mø functions in vitro. We characterized the mediators of inflammation produced by human peritoneal Mø (hp-Mø) obtained from patients with portal hypertension and ...
Bonta, I.L. +5 more
core +1 more source