Results 101 to 110 of about 33,480 (278)

Stereopermutation on the Putative Structure of the Marine Natural Product Mucosin

Molecules, 2017
A stereodivergent total synthesis has been executed based on the plausibly misassigned structure of the unusual marine hydrindane mucosin (1). The topological connectivity of the four contiguous all-carbon stereocenters has been examined by selective ...
Simen G. Antonsen, Harrison Gallantree-Smith, Carl Henrik Görbitz, Trond Vidar Hansen, Yngve H. Stenstrøm, Jens M. J. Nolsøe   +5 more
doaj   +1 more source

Differential release of histamine and eicosanoids from human skin mast cells activated by IgE‐dependent and non‐immunological stimuli [PDF]

, 1989
R. Christopher Benyon, C. Robinson, Martin K. Church   +2 more
openalex   +1 more source

Comparison of viscoelastic coagulation parameters, blood loss and surgical time between asymptomatic heartworm antigen‐positive and negative dogs presented for elective gonadectomy

Journal of Small Animal Practice, EarlyView.
Objectives The primary objective of this study was to evaluate viscoelastic profiles in heartworm antigen‐positive versus antigen‐negative dogs using a point‐of‐care viscoelastic device. A secondary objective was to compare intraoperative bleeding and surgical duration between these same groups.
B. K. Newmans, J. M. Fudge, R. Clarkin‐Breslin, D. C. Silverstein, G. G. Verocai   +4 more
wiley   +1 more source

Genomic and lipidomic analyses differentiate the compensatory roles of two COX isoforms during systemic inflammation in mice1,2[S]

Journal of Lipid Research, 2018
Both cyclooxygenase (COX)-1 and COX-2, encoded by Ptgs1 and Ptgs2, function coordinately during inflammation. But the relative contributions and compensations of COX-1 and COX-2 to inflammatory responses remain unanswered.
Xinzhi Li, Liudmila L. Mazaleuskaya, Laurel L. Ballantyne, Hu Meng, Garret A. FitzGerald, Colin D. Funk   +5 more
doaj  

Endocannabinoid Oxygenation by Cyclooxygenases, Lipoxygenases, and Cytochromes P450: Cross-Talk between the Eicosanoid and Endocannabinoid Signaling Pathways

Chemical Reviews, 2011
The discovery of the cannabinoid receptors CB1 and CB2 in 19881,2 and 1990,(3) respectively, and of the endogenous cannabinoid ligands (endocannabinoids) arachidonoylethanolamide (AEA) and 2-arachidonoylglycerol (2-AG) in 1992(4) and 1995,(5 ...
C. Rouzer, L. Marnett
semanticscholar   +1 more source

Implications for soluble iron accumulation, oxidative stress, and glial glutamate release in motor neuron death associated with sporadic amyotrophic lateral sclerosis

Neuropathology, EarlyView.
Oxidative stress in sporadic amyotrophic lateral sclerosis (ALS) has been evidenced by accumulation of oxidatively modified products of nucleic acids, lipids, sugars, and proteins in the motor neuron system of brains and spinal cords obtained at autopsy from the patients.
Noriyuki Shibata, Ikuko Kataoka, Yukinori Okamura, Kumiko Murakami, Yoichiro Kato, Tomoko Yamamoto, Kenta Masui   +6 more
wiley   +1 more source

Temporal changes of cytochrome P450 (Cyp) and eicosanoid-related gene expression in the rat brain after traumatic brain injury

BMC Genomics, 2013
BackgroundTraumatic brain injury (TBI) induces arachidonic acid (ArA) release from cell membranes. ArA metabolites form a class of over 50 bioactive eicosanoids that can induce both adaptive and/or maladaptive brain responses.
Matthew Birnie, Ryan Morrison, R. Camara, K. Strauss   +3 more
semanticscholar   +1 more source

Excessive hypercholesterolaemia during pregnancy as a risk factor for endothelial dysfunction in pre‐eclampsia

The Journal of Physiology, EarlyView.
Abstract figure legend Excessive hypercholesterolaemia during pregnancy impairs maternal endothelial function, which, in turn, drives the development of pre‐eclampsia and may also contribute to the increased risk of later‐life cardiovascular disease in women.
Amanda A. de Oliveira, Floor Spaans, Christy‐Lynn M. Cooke, Sandra T. Davidge   +3 more
wiley   +1 more source

Omega-3 fatty acids cause dramatic changes in TLR4 and purinergic eicosanoid signaling

Proceedings of the National Academy of Sciences of the United States of America, 2012
Dietary fish oil containing ω3 fatty acids, eicosapentaenoic acid (EPA) and docosahexaenoic acid (DHA), elicit cardioprotective and anti-inflammatory effects through unresolved mechanisms that may involve competition and inhibition at multiple levels ...
Paul C. Norris, E. Dennis
semanticscholar   +1 more source

Mitochondrial control of ciliary gene expression and structure in striatal neurons

The Journal of Physiology, EarlyView.
Abstract figure legend Neurons drive animal behaviour by receiving and transmitting information and require energy, primarily supplied by mitochondria, to function. Additionally, neurons need to sense environmental changes to adapt, a function that is locally played by the primary cilia.
Dogukan H. Ulgen, Alessandro Chioino, Olivia Zanoletti, Albert Quintana, Elisenda Sanz, Carmen Sandi   +5 more
wiley   +1 more source