Results 11 to 20 of about 53,789 (311)

Eicosanoid and eicosanoid-related inflammatory mediators and exercise intolerance in heart failure with preserved ejection fraction

Nature Communications, 2023
Systemic inflammation has been implicated in the pathobiology of heart failure with preserved ejection fraction (HFpEF). Here, we examine the association of upstream mediators of inflammation as ascertained by fatty-acid derived eicosanoid and eicosanoid-
Emily S. Lau, Athar Roshandelpoor, Shahrooz Zarbafian, Dongyu Wang, James S. Guseh, Norrina Allen, Vinithra Varadarajan, Matthew Nayor, Ravi V. Shah, Joao A. C. Lima, Sanjiv J. Shah, Bing Yu, Mona Alotaibi, Susan Cheng, Mohit Jain, Gregory D. Lewis, Jennifer E. Ho   +16 more
doaj   +2 more sources

A combined computational strategy of sequence and structural analysis predicts the existence of a functional eicosanoid pathway in Drosophila melanogaster.

PLoS ONE, 2019
This study reports on a putative eicosanoid biosynthesis pathway in Drosophila melanogaster and challenges the currently held view that mechanistic routes to synthesize eicosanoid or eicosanoid-like biolipids do not exist in insects, since to date ...
Michael Scarpati, Yan Qi, Shubha Govind, Shaneen Singh   +3 more
doaj   +2 more sources

Eicosanoids [PDF]

Essays in Biochemistry, 2020
Abstract This article describes the pathways of eicosanoid synthesis, eicosanoid receptors, the action of eicosanoids in different physiological systems, the roles of eicosanoids in selected diseases, and the major inhibitors of eicosanoid synthesis and action. Eicosanoids are oxidised derivatives of 20-carbon polyunsaturated fatty acids
Hammock, Bruce D., Wang, Weicang, Gilligan, Molly M., Panigrahy, Dipak   +3 more
  +8 more sources

Phospholipase A₂regulates eicosanoid class switching during inflammasome activation [PDF]

Proceedings of the National Academy of Sciences of the United States of America, 2014
Paul C. Norris, David Gosselin, Donna Reichart, Christopher K. Glass, Edward A. Dennis   +4 more
openalex   +2 more sources

Cytosolic Phospholipase A2α and Eicosanoids Regulate Expression of Genes in Macrophages Involved in Host Defense and Inflammation [PDF]

, 2013
Acknowledgments: We thank Dr. Robert Barkley and Charis Uhlson for mass spectrometry analysis. Funding: This work was supported by grants from the National Institutes of Health HL34303 (to C.C.L., R.C.M. and D.L.B), DK54741 (to J.V.B.), GM5322 (to D.L.W.)
Bonventre, Joseph V., Bratton, Donna L., Brown, Gordon D., Gow, Neil A. R., Leslie, Christina C., Mahaffey, Spencer, Murphy, Robert C., Silveira, Lori J., Suram, Saritha, Williams, David L.   +9 more
core   +12 more sources

The association of eicosanoids and eicosanoid-related metabolites with pulmonary hypertension

European Respiratory Journal, 2023
Background Eicosanoids are bioactive lipids that regulate systemic inflammation and exert vasoactive effects. Specific eicosanoid metabolites have previously been associated with pulmonary hypertension (PH), yet their role remains incompletely understood.
J. McNeill, A. Roshandelpoor, M. Alotaibi, A. Choudhary, Mohit Jain, Su-Shiang Cheng, Shahrooz Zarbafian, E. Lau, Gregory D. Lewis, Jennifer E. Ho   +9 more
semanticscholar   +1 more source

Eicosanoid lipidome activation in post-mortem brain tissues of individuals with APOE4 and Alzheimer’s dementia

Alzheimer's Research & Therapy, 2022
Background Chronic neuroinflammation is one of the hallmarks of late-onset Alzheimer’s disease (AD) dementia pathogenesis. Carrying the apolipoprotein ε4 ( APOE4 ) allele has been associated with an accentuated response to brain inflammation and ...
Brandon Ebright, Isaac Assante, R. Poblete, Shaowei Wang, Marlon V. Duro, David A. Bennett, Z. Arvanitakis, S. Louie, Hussein N. Yassine   +8 more
semanticscholar   +1 more source

Mild COVID-19 imprints a long-term inflammatory eicosanoid- and chemokine memory in monocyte-derived macrophages

Mucosal Immunology, 2022
Monocyte-derived macrophages (MDM) drive the inflammatory response to severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) and they are a major source of eicosanoids in airway inflammation.
Sina Bohnacker, F. Hartung, Fiona D. R. Henkel, A. Quaranta, J. Kolmert, Alina Priller, Minhaz Ud-Dean, Johanna Giglberger, Luisa M. Kugler, L. Pechtold, Sarah Yazici, A. Lechner, J. Erber, U. Protzer, P. Lingor, P. Knolle, A. Chaker, C. Schmidt‐Weber, C. Wheelock, Julia Esser‐von Bieren   +19 more
semanticscholar   +1 more source

Red blood cell transfusion-related eicosanoid profiles in intensive care patients—A prospective, observational feasibility study

Frontiers in Physiology, 2023
Introduction: Eicosanoids are bioactive lipids present in packed red blood cells (PRBCs), and might play a role in transfusion-related immunomodulation (TRIM).
Pierre Raeven, Gerhard Hagn, Laura Niederstaetter, Jonas Brugger, Sophia Bayer-Blauensteiner, Christoph Domenig, Konrad Hoetzenecker, Martin Posch, Gerda Leitner, Christopher Gerner, Christopher Gerner, David M. Baron   +11 more
doaj   +1 more source

Eicosanoid Signaling in Insect Immunology: New Genes and Unresolved Issues

Genes, 2021
This paper is focused on eicosanoid signaling in insect immunology. We begin with eicosanoid biosynthesis through the actions of phospholipase A2, responsible for hydrolyzing the C18 polyunsaturated fatty acid, linoleic acid (18:2n-6), from cellular ...
Yonggyun Kim, D. Stanley
semanticscholar   +1 more source