Results 11 to 20 of about 33,906 (210)

Eicosanoids [PDF]

Essays in Biochemistry, 2020
Abstract This article describes the pathways of eicosanoid synthesis, eicosanoid receptors, the action of eicosanoids in different physiological systems, the roles of eicosanoids in selected diseases, and the major inhibitors of eicosanoid synthesis and action. Eicosanoids are oxidised derivatives of 20-carbon polyunsaturated fatty acids
Hammock, Bruce D., Wang, Weicang, Gilligan, Molly M., Panigrahy, Dipak   +3 more
  +8 more sources

Emergence of highly profibrotic and proinflammatory Lrat+Fbln2+ HSC subpopulation in alcoholic hepatitis

Hepatology, EarlyView., 2022
Lrat+ quiescent hepatic stellate cells (qHSC) give rise to Lrat+Fbln2+ activated HSC (aHSC) in alcohol‐associated hepatitis and this subpopulation is highly profibrotic, inflammatory, and immunoregulatory based on their single cell transcriptomic profile. Abstract Background and Aims Relative roles of HSCs and portal fibroblasts in alcoholic hepatitis (
Steven Balog, Reika Fujiwara, Stephanie Q. Pan, Khairat B. El‐Baradie, Hye Yeon Choi, Sonal Sinha, Qihong Yang, Kinji Asahina, Yibu Chen, Meng Li, Matthew Salomon, Stanley W.‐K. Ng, Hidekazu Tsukamoto   +12 more
wiley   +1 more source

In Vitro Modeling of Age-Associated Lipid Mediator's Impact on Vascular Biology Following Platelet Concentrate Transfusion. [PDF]

Aging Cell
Age‐associated LPA affects adverse reactions and alters platelet and endothelial biology following platelet concentrate transfusion. Age‐associated LPC, S1P could be involved in adverse reactions, in platelet and endothelium biology following a PC transfusion.
Prier A, Portier M, Heranney C, Kouadio N, Arthaud CA, Eyraud MA, Heestermans M, Bertrand-Michel J, Hamzeh-Cognasse H, Cognasse F, Duchez AC.   +10 more
europepmc   +2 more sources

FADS2 function loss at the cancer hotspot 11q13 locus diverts lipid signaling precursor synthesis to unusual eicosanoid fatty acids. [PDF]

PLoS ONE, 2011
BACKGROUND: Genes coding for the fatty acid desaturases (FADS1, 2, 3) localized at the cancer genomic hotspot 11q13 locus are required for the biosynthesis of 20 carbon polyunsaturated fatty acids (PUFA) that are direct eicosanoid precursors.
Woo Jung Park, Kumar S D Kothapalli, Peter Lawrence, J Thomas Brenna   +3 more
doaj   +1 more source

2-Oxoesters: A Novel Class of Potent and Selective Inhibitors of Cytosolic Group IVA Phospholipase A2. [PDF]

, 2017
Cytosolic phospholipase A2 (GIVA cPLA2) is the only PLA2 that exhibits a marked preference for hydrolysis of arachidonic acid containing phospholipid substrates releasing free arachidonic acid and lysophospholipids and giving rise to the generation of ...
Barbayianni, Efrosini, Dennis, Edward A, Galiatsatou, Gerasimia, Kokotos, George, Kokotou, Maroula G, Koutoulogenis, Giorgos, Limnios, Dimitris, Magrioti, Victoria, Mouchlis, Varnavas D, Navratil, Aaron, Satpathy, Banita   +10 more
core   +1 more source

Marked elevations in pro-inflammatory polyunsaturated fatty acid metabolites in females with irritable bowel syndrome

Journal of Lipid Research, 2010
Irritable bowel syndrome (IBS) is the most common functional gastrointestinal disorder referred to gastroenterologists. Although the pathophysiology remains unclear, accumulating evidence points to the presence of low-level immune activation both in the ...
Gerard Clarke, Peter Fitzgerald, Alan A. Hennessy, Eugene M. Cassidy, Eamonn M.M. Quigley, Paul Ross, Catherine Stanton, John F. Cryan, Timothy G. Dinan   +8 more
doaj   +1 more source

A genome-wide association study identifies 41 loci associated with eicosanoid levels

Communications Biology, 2023
Eicosanoids are biologically active derivatives of polyunsaturated fatty acids with broad relevance to health and disease. We report a genome-wide association study in 8406 participants of the Atherosclerosis Risk in Communities Study, identifying 41 ...
Eugene P. Rhee, Aditya L. Surapaneni, Pascal Schlosser, Mona Alotaibi, Yueh-ning Yang, Josef Coresh, Mohit Jain, Susan Cheng, Bing Yu, Morgan E. Grams   +9 more
doaj   +1 more source

Anopheles gambiae eicosanoids modulate Plasmodium berghei survival from oocyst to salivary gland invasion

Memorias do Instituto Oswaldo Cruz, 2014
Eicosanoids affect the immunity of several pathogen/insect models, but their role on the Anopheles gambiae response to Plasmodium is still unknown.
Susana Ramos, Ana Custódio, Henrique Silveira   +2 more
doaj   +1 more source

Pleiotropic Functions of Cytochrome P450 Monooxygenase-Derived Eicosanoids in Cancer

Frontiers in Pharmacology, 2020
Eicosanoids are a class of functionally bioactive lipid mediators derived from the metabolism of long-chain polyunsaturated fatty acids (PUFAs) mediated by multiple enzymes of three main branches, including cyclooxygenases (COXs), lipoxygenases (LOXs ...
Ying Luo, Jun-Yan Liu
doaj   +1 more source

Eicosanoid and eicosanoid-related inflammatory mediators and exercise intolerance in heart failure with preserved ejection fraction

Nature Communications, 2023
Systemic inflammation has been implicated in the pathobiology of heart failure with preserved ejection fraction (HFpEF). Here, we examine the association of upstream mediators of inflammation as ascertained by fatty-acid derived eicosanoid and eicosanoid-
Emily S. Lau, Athar Roshandelpoor, Shahrooz Zarbafian, Dongyu Wang, James S. Guseh, Norrina Allen, Vinithra Varadarajan, Matthew Nayor, Ravi V. Shah, Joao A. C. Lima, Sanjiv J. Shah, Bing Yu, Mona Alotaibi, Susan Cheng, Mohit Jain, Gregory D. Lewis, Jennifer E. Ho   +16 more
doaj   +1 more source