Results 21 to 30 of about 53,789 (311)

Deciphering Complex Interactions in Bioactive Lipid Signaling

Molecules, 2023
Lipids are usually viewed as metabolic fuel and structural membrane components. Yet, in recent years, different families of lipids able to act as authentic messengers between cells and/or intracellularly have been discovered. Such lipid signals have been
Mauro Maccarrone
doaj   +1 more source

Dorsal switch protein 1 as a damage signal in insect gut immunity to activate dual oxidase via an eicosanoid, PGE2

Frontiers in Immunology, 2022
Various microbiota including beneficial symbionts reside in the insect gut. Infections of pathogens cause dysregulation of the microflora and threaten insect survival. Reactive oxygen species (ROS) have been used in the gut immune responses, in which its
Miltan Chandra Roy, Shabbir Ahmed, Yonggyun Kim   +2 more
doaj   +1 more source

Emergence of highly profibrotic and proinflammatory Lrat+Fbln2+ HSC subpopulation in alcoholic hepatitis

Hepatology, EarlyView., 2022
Lrat+ quiescent hepatic stellate cells (qHSC) give rise to Lrat+Fbln2+ activated HSC (aHSC) in alcohol‐associated hepatitis and this subpopulation is highly profibrotic, inflammatory, and immunoregulatory based on their single cell transcriptomic profile. Abstract Background and Aims Relative roles of HSCs and portal fibroblasts in alcoholic hepatitis (
Steven Balog, Reika Fujiwara, Stephanie Q. Pan, Khairat B. El‐Baradie, Hye Yeon Choi, Sonal Sinha, Qihong Yang, Kinji Asahina, Yibu Chen, Meng Li, Matthew Salomon, Stanley W.‐K. Ng, Hidekazu Tsukamoto   +12 more
wiley   +1 more source

Plasma Oxylipins and Their Precursors Are Strongly Associated with COVID-19 Severity and with Immune Response Markers

Metabolites, 2022
COVID-19 is characterised by a dysregulated immune response, that involves signalling lipids acting as mediators of the inflammatory process along the innate and adaptive phases.
Naama Karu, Alida Kindt, Lieke Lamont, Adriaan J. van Gammeren, Anton A. M. Ermens, Amy C. Harms, Lutzen Portengen, Roel C. H. Vermeulen, Willem A. Dik, Anton W. Langerak, Vincent H. J. van der Velden, Thomas Hankemeier   +11 more
doaj   +1 more source

Cutting Edge: Severe SARS-CoV-2 Infection in Humans Is Defined by a Shift in the Serum Lipidome, Resulting in Dysregulation of Eicosanoid Immune Mediators

Journal of Immunology, 2020
Key Points Systemic lipidomic changes distinguish COVID-19 disease severity in humans. Lipidomic changes correspond to different levels of immune lipid mediators. Lipid mediator differences correlate with BMI, hypertension, and heart disease.
Benjamin Schwarz, L. Sharma, Lydia M. Roberts, Xiaohua Peng, S. Bermejo, I. Leighton, A. Casanovas-Massana, M. Minasyan, S. Farhadian, A. Ko, C. D. Dela Cruz, C. Bosio   +11 more
semanticscholar   +1 more source

Eicosanoid regulation of debris-stimulated metastasis

Proceedings of the National Academy of Sciences of the United States of America, 2021
Significance Cancer therapy, such as chemotherapy, induces tumor cell death (“debris”), which can stimulate metastasis. Chemotherapy-generated debris upregulates soluble epoxide hydrolase (sEH) and the prostaglandin E2 receptor 4 (EP4), which triggers a ...
Jianjun Deng, Haixia Yang, Victoria M. Haak, Jun Yang, F. Kipper, Chantal Barksdale, S. Hwang, Allison Gartung, D. Bielenberg, S. Subbian, Koc-Kan Ho, Xiang Ye, Daidi Fan, Yong-jun Sun, B. Hammock, D. Panigrahy   +15 more
semanticscholar   +1 more source

Resolution of eicosanoid/cytokine storm prevents carcinogen and inflammation-initiated hepatocellular cancer progression

Proceedings of the National Academy of Sciences of the United States of America, 2020
Significance Eicosanoid and cytokine storms are poorly characterized in cancer. Our study demonstrates the environmental carcinogen aflatoxin B1 (AFB1) promotes hepatocellular carcinoma (HCC) by triggering a debris-stimulated proinflammatory and ...
A. Fishbein, Weicang Wang, Haixia Yang, Jun Yang, Victoria M. Hallisey, Jianjun Deng, Sanne M. L. Verheul, S. Hwang, Allison Gartung, Yuxin Wang, D. Bielenberg, Sui Huang, M. Kieran, B. Hammock, D. Panigrahy   +14 more
semanticscholar   +1 more source

Consequences of altered eicosanoid patterns for nociceptive processing in mPGES-1-deficient mice [PDF]

, 2007
Cyclooxygenase-2 (COX-2)-dependent prostaglandin (PG) E2 synthesis in the spinal cord plays a major role in the development of inflammatory hyperalgesia and allodynia. Microsomal PGE2 synthase-1 (mPGES-1) isomerizes COX-2-derived PGH2 to PGE2.
Angioni, Carlo Federico, Becker, Wiebke, Brenneis, Christian, Coste, Ovidiu, Geisslinger, Gerd, Nusing, Rolf M., Popp, Laura, Schmidt, Ronald, Scholich, Klaus   +8 more
core   +1 more source

Eicosanoid release is increased by membrane destabilization and CFTR inhibition in Calu-3 cells. [PDF]

PLoS ONE, 2009
The antiinflammatory protein annexin-1 (ANXA1) and the adaptor S100A10 (p11), inhibit cytosolic phospholipase A2 (cPLA2alpha) by direct interaction. Since the latter is responsible for the cleavage of arachidonic acid at membrane phospholipids, all three
Florence Borot, Diane-Lore Vieu, Grazyna Faure, Janine Fritsch, Julien Colas, Sandra Moriceau, Maryvonne Baudouin-Legros, Franck Brouillard, Jesus Ayala-Sanmartin, Lhousseine Touqui, Marc Chanson, Aleksander Edelman, Mario Ollero   +12 more
doaj   +1 more source

Prostanoid Metabolites as Biomarkers in Human Disease

Metabolites, 2022
Prostaglandins (PGD2, PGE2, PGF2α), prostacyclin (PGI2), and thromboxane A2 (TXA2) together form the prostanoid family of lipid mediators. As autacoids, these five primary prostanoids propagate intercellular signals and are involved in many physiological
Helena Idborg, Sven-Christian Pawelzik
doaj   +1 more source