Results 31 to 40 of about 33,480 (278)

A genome-wide association study identifies 41 loci associated with eicosanoid levels

Communications Biology, 2023
Eicosanoids are biologically active derivatives of polyunsaturated fatty acids with broad relevance to health and disease. We report a genome-wide association study in 8406 participants of the Atherosclerosis Risk in Communities Study, identifying 41 ...
Eugene P. Rhee, Aditya L. Surapaneni, Pascal Schlosser, Mona Alotaibi, Yueh-ning Yang, Josef Coresh, Mohit Jain, Susan Cheng, Bing Yu, Morgan E. Grams   +9 more
doaj   +1 more source

Salicylic Acid, a Plant Hormone, Suppresses Phytophagous Insect Immune Response by Interrupting HMG-Like DSP1

Frontiers in Physiology, 2021
Salicylic acid is a plant hormone that can mediate various plant physiological processes. Salicylic acid can bind to human high mobility group box 1 (HMGB1) and interrupt its role in mediating immune responses. Dorsal switch protein 1 (DSP1) is an insect
Md. Mahi Imam Mollah, Hyong Woo Choi, Inhwa Yeam, Je Min Lee, Yonggyun Kim   +4 more
doaj   +1 more source

Plantar osteochondral fragments in young Standardbreds are associated with minimal joint inflammation at the time of surgical removal

Equine Veterinary Journal, Volume 55, Issue 1, Page 33-41, January 2023., 2023
Abstract Background Plantar osteochondral fragments (POF) are common but their effect on joint health of young Standardbreds in race training is largely unknown. Objectives Evaluate the inflammatory effects of POF in metatarsophalangeal joints of young Standardbreds as a step towards developing evidence‐based recommendations for surgical removal. Study
Annette M. McCoy, Erica J. Secor, Patrick J. Roady, Sarah M. Gray, Julie Klein, Santiago D. Gutierrez‐Nibeyro   +5 more
wiley   +1 more source

Structural Manipulation of Eicosanoid Receptors and Cellular Signaling

The Scientific World Journal, 2007
Eicosanoids are lipid mediators derived from the metabolism of arachidonic acid. These agents are locally released and activate different cell membrane receptors, and the latter are part of the G-protein coupled receptor family.
Charles Brink
doaj   +1 more source

Immunoregulatory and anti-inflammatory effects of n-3 polyunsaturated fatty acids

Brazilian Journal of Medical and Biological Research, 1998
1. Fish oils are rich in the long-chain n-3 polyunsaturated fatty acids (PUFAs), eicosapentaenoic (20:5n-3) and docosahexaenoic (22:6n-3) acids. Linseed oil and green plant tissues are rich in the precursor fatty acid, a-linolenic acid (18:3n-3).
P.C. Calder
doaj   +1 more source

The effects of FTO gene rs9939609 polymorphism on the association between breast cancer and dietary intake

Journal of Cellular and Molecular Medicine, Volume 26, Issue 23, Page 5794-5806, December 2022., 2022
Abstract Breast cancer (BC) is the leading cause of cancer‐related deaths in females worldwide and is related to genetic and environmental factors. Dietary components may strongly influence the risk of BC. A possible association was also reported between the fat mass and obesity‐associated (FTO) single‐nucleotide polymorphisms (SNPs) and BC. This study
Saeid Doaei, Sepideh Abdollahi, Golsa Khalatbari Mohseni, Maryam Gholamalizadeh, Mohammad Esmail Akbari, Seyed Mohammad Poorhosseini, Seyedeh Elaheh Bagheri, Soudeh Ghafouri‐Fard, Ghasem Azizi Tabesh, Alireza Moslem, Naeemeh Hasanpour Ardekanizadeh, Saeed Omidi, Azita Hekmatdoost, Mahdi Alam Rajabi, Seyed Alireza Mosavi Jarrahi, Mark O. Goodarzi   +15 more
wiley   +1 more source

Anopheles gambiae eicosanoids modulate Plasmodium berghei survival from oocyst to salivary gland invasion

Memorias do Instituto Oswaldo Cruz, 2014
Eicosanoids affect the immunity of several pathogen/insect models, but their role on the Anopheles gambiae response to Plasmodium is still unknown.
Susana Ramos, Ana Custódio, Henrique Silveira   +2 more
doaj   +1 more source

Investigation of the Association between High Arachidonic Acid Synthesis and Colorectal Polyp Incidence within a Generally Healthy UK Population: A Mendelian Randomization Approach

Lifestyle Genomics, 2022
Background: Arachidonic acid (ARA) is associated with colorectal cancer (CRC), a major public health concern. However, it is uncertain if ARA contributes to the development of colorectal polyps which are pre-malignant precursors of CRC.
Rachel Moon, J. Bernadette Moore, Mark A. Hull, Michael A. Zulyniak   +3 more
doaj   +1 more source

Targeted Metabolomics Identifies the Cytochrome P450 Monooxygenase Eicosanoid Pathway as a Novel Therapeutic Target of Colon Tumorigenesis.

Cancer Research, 2019
Colon cancer is the third most common cancer and the second leading cause of cancer-related death in the United States, emphasizing the need for the discovery of new cellular targets.
Weicang Wang, Jun Yang, M. Edin, Yuxin Wang, Ying Luo, Debin Wan, Haixia Yang, Chun‐Qing Song, Wen Xue, Katherine Z. Sanidad, Mingyue Song, Heather A Bisbee, J. Bradbury, Guanjun Nan, Jianan Zhang, P. B. Shih, K. S. Lee, L. Minter, Daeyoung Kim, Hang Xiao, Jun-Yan Liu, B. Hammock, D. Zeldin, Guodong Zhang   +23 more
semanticscholar   +1 more source

Bioactive food components and their inhibitory actions in multiple platelet pathways

Journal of Food Biochemistry, Volume 46, Issue 12, December 2022., 2022
A comprehensive overview of platelet multifunctional roles in CVD and other diseases and the effects of food components' modulatory effects are described. Abstract In addition to hemostasis and thrombosis, blood platelets are involved in various processes such as inflammation, infection, immunobiology, cancer metastasis, wound repair and angiogenesis ...
Diptimayee Das, Shubhamay Adhikary, Ranjit Kumar Das, Antara Banerjee, Arun Kumar Radhakrishnan, Sujay Paul, Surajit Pathak, Asim K. Duttaroy   +7 more
wiley   +1 more source