Urinary eicosanoid metabolites in HIV-infected women with central obesity switching to raltegravir: an analysis from the women, integrase, and fat accumulation trial. [PDF]
, 2014 Chronic inflammation is a hallmark of HIV infection. Eicosanoids reflect inflammation, oxidant stress, and vascular health and vary by sex and metabolic parameters. Raltegravir (RAL) is an HIV-1 integrase inhibitor that may have limited metabolic effects.
Boger, M Sean +11 more
core +7 more sources
Amyloid proteotoxicity initiates an inflammatory response blocked by cannabinoids. [PDF]
, 2016 The beta amyloid (Aβ) and other aggregating proteins in the brain increase with age and are frequently found within neurons. The mechanistic relationship between intracellular amyloid, aging and neurodegeneration is not, however, well understood.
Currais, Antonio +5 more
core +2 more sources
Lifestyle Genomics, 2022 Background: Arachidonic acid (ARA) is associated with colorectal cancer (CRC), a major public health concern. However, it is uncertain if ARA contributes to the development of colorectal polyps which are pre-malignant precursors of CRC.
Rachel Moon +3 more
doaj +1 more source
Candida albicans and Pseudomonas aeruginosa interaction, with focus on the role of eicosanoids
Frontiers in Physiology, 2016 Candida albicans is commonly found in mixed infections with Pseudomonas aeruginosa, especially in the lungs of cystic fibrosis patients. Both of these opportunistic pathogens are able to form resistant biofilms and frequently infect immunocompromised ...
Ruan eFourie +6 more
doaj +1 more source
Statistical Workflow for Feature Selection in Human Metabolomics Data. [PDF]
, 2019 High-throughput metabolomics investigations, when conducted in large human cohorts, represent a potentially powerful tool for elucidating the biochemical diversity underlying human health and disease.
Antonelli, Joseph +17 more
core +2 more sources
Interactions between the endocrine and immune systems in locusts [PDF]
, 2003 The prophenoloxidase cascade in the haemolymph of mature adult Locusta migratoria migratorioides (R & F) is activated in response to injection of laminarin, a -1,3 glucan.
Chandrakant, S. +3 more
core +1 more source
Prostanoid Metabolites as Biomarkers in Human Disease
Metabolites, 2022 Prostaglandins (PGD2, PGE2, PGF2α), prostacyclin (PGI2), and thromboxane A2 (TXA2) together form the prostanoid family of lipid mediators. As autacoids, these five primary prostanoids propagate intercellular signals and are involved in many physiological
Helena Idborg, Sven-Christian Pawelzik
doaj +1 more source
Staphylococcus aureus enterotoxin B regulates prostaglandin E-2 synthesis, growth, and migration in nasal tissue fibroblasts [PDF]
, 2008 Background. Superantigens and eicosanoids are important amplifiers and regulators of inflammation in airway diseases. We therefore studied the possible influence of Staphylococcus aureus enterotoxin B ( SEB) on the cyclooxygenase ( COX) pathway and basic
Bachert, Claus +4 more
core +2 more sources
Thematic Review Series: Proteomics. An integrated omics analysis of eicosanoid biology1[S]
Journal of Lipid Research, 2009 Eicosanoids have been implicated in a vast number of devastating inflammatory conditions, including arthritis, atherosclerosis, pain, and cancer. Currently, over a hundred different eicosanoids have been identified, with many having potent bioactive ...
Matthew W. Buczynski +2 more
doaj +1 more source
Total synthesis of the endogenous inflammation resolving lipid resolvin D2 using a common lynchpin
Beilstein Journal of Organic Chemistry, 2013 The total synthesis of the endogenous inflammation resolving eicosanoid resolvin D2 (1) is described. The key steps involved a Wittig reaction between aldehyde 5 and the ylide derived from phosphonium salt 6 to give enyne 17 and condensation of the same ...
John Li +3 more
doaj +1 more source