Results 61 to 70 of about 53,789 (311)

Statistical Workflow for Feature Selection in Human Metabolomics Data. [PDF]

, 2019
High-throughput metabolomics investigations, when conducted in large human cohorts, represent a potentially powerful tool for elucidating the biochemical diversity underlying human health and disease.
Antonelli, Joseph, Cheng, Susan, Claggett, Brian L, Demler, Olga V, Deng, Katherine, Henglin, Mir, Hushcha, Pavel V, Jain, Mohit, Kim, Andy, Kim, Nicole, Lagerborg, Kim A, Mora, Samia, Niiranen, Teemu J, Ovsak, Gavin, Pereira, Alexandre C, Rao, Kevin, Tyagi, Octavia, Watrous, Jeramie D   +17 more
core   +2 more sources

Eicosapentaenoic acid induces DNA demethylation in carcinoma cells through a TET1-dependent mechanism [PDF]

, 2018
In cancer cells, global genomic hypomethylation is found together with localized hypermethylation of CpG islands within the promoters and regulatory regions of silenced tumor suppressor genes.
Billi, Monia, Cannarile, Lorenza, Ceccarelli, Veronica, Grignani, Francesco, Ottini, Laura, Riccardi, Carlo, Ronchetti, Simona, Talesa, Vincenzo Nicola, Valentini, Virginia, Vecchini, Alba   +9 more
core   +1 more source

Repat33 Acts as a Downstream Component of Eicosanoid Signaling Pathway Mediating Immune Responses of Spodoptera exigua, a Lepidopteran Insect

Insects, 2021
Repat (=response to pathogen) is proposed for an immune-associated gene family from Spodoptera exigua, a lepidopteran insect. In this gene family, 46 members (Repat1–Repat46) have been identified. They show marked variations in their inducible expression
Md Tafim Hossain Hrithik, Mohammad Vatanparast, Shabbir Ahmed, Yonggyun Kim   +3 more
doaj   +1 more source

Obesity in Aging Exacerbates Neuroinflammation, Dysregulating Synaptic Function-Related Genes and Altering Eicosanoid Synthesis in the Mouse Hippocampus: Potential Role in Impaired Synaptic Plasticity and Cognitive Decline

The journals of gerontology. Series A, Biological sciences and medical sciences, 2018
There is strong evidence that obesity has deleterious effects on cognitive function of older adults. Previous preclinical studies demonstrate that obesity in aging is associated with a heightened state of systemic inflammation, which exacerbates blood ...
M. N. Valcarcel-Ares, Zsuzsanna Tucsek, T. Kiss, Cory B. Giles, Stefano Tarantini, A. Yabluchanskiy, Priya Balasubramanian, Tripti Gautam, V. Galvan, Praveen Ballabh, A. Richardson, W. Freeman, J. Wren, F. Deák, Z. Ungvari, A. Csiszar   +15 more
semanticscholar   +1 more source

S1R agonist modulates rat platelet eicosanoid synthesis and aggregation

Platelets, 2022
Sigma-1 receptor (S1R) is detected in different cell types and can regulate intracellular signaling pathways. S1R plays a role in the pathomechanism of diseases and the regulation of neurotransmitters. Fluvoxamine can bind to S1R and reduce the serotonin
Sándor Váczi, L. Barna, A. Harazin, M. Mészáros, G. Porkoláb, Á. Zvara, R. Ónody, I. Földesi, S. Veszelka, B. Penke, L. Fülöp, M. A. Deli, Z. Mezei   +12 more
doaj   +1 more source

Role of Oxylipins in the Inflammatory-Related Diseases NAFLD, Obesity, and Type 2 Diabetes

Metabolites, 2022
Oxygenated polyunsaturated fatty acids (oxylipins) are bioactive molecules established as important mediators during inflammation. Different classes of oxylipins have been found to have opposite effects, e.g., pro-inflammatory prostaglandins and anti ...
Mariya Misheva, Jethro Johnson, James McCullagh   +2 more
doaj   +1 more source

Antithetic relationship of dietary arachidonic acid and eicosapentaenoic acid on eicosanoid production in vivo

Journal of Lipid Research, 1994
Eicosanoids are oxidative derivatives of arachidonic acid. When produced in excessive amounts, many are proinflammatory and/or prothrombotic agents. N-3 polyunsaturated fatty acids (PUFA) have been used to attenuate tissue arachidonic acid (AA, 20:4 n-6)
B Li, C Birdwell, J Whelan
doaj   +1 more source

Regulation of Eicosanoid Pathways by MicroRNAs

Frontiers in Pharmacology, 2019
Over the last years, many microRNAs (miRNAs) have been identified that regulate the formation of bioactive lipid mediators such as prostanoids and leukotrienes.
Meike J. Saul, Anne C. Emmerich, D. Steinhilber, B. Suess   +3 more
semanticscholar   +1 more source

Postoperative Stress Accelerates Atherosclerosis Through Inflammatory Remodeling of the HDL Proteome and Impaired Reverse Cholesterol Transport

Advanced Science, EarlyView.
The study shows that noncardiac surgical inflammation rapidly disrupts HDL function and cholesterol efflux in mice and human patients. Impaired reverse cholesterol transport after surgery drives rapid lipid accumulation, NETosis, and apoptosis within atherosclerotic plaques.
Dominique M. Boucher, Victoria Lorant, Valerie Rochon, Abigail Carter, Cameron Stotts, My‐Anh Nguyen, Thomas Laval, Christina Emerton, Nathan Joyce, Nysa Vinayak, Marlena Scaffidi, David Cook, Katey J. Rayner, Rebecca C. Auer, Scott M. Gordon, Mireille I. Ouimet   +15 more
wiley   +1 more source

Effect of Cyclooxygenase(COX)-1 and COX-2 inhibition on furosemide-induced renal responses and isoform immunolocalization in the healthy cat kidney [PDF]

, 2015
BACKGROUND: The role of cyclooxygenase(COX)-1 and COX-2 in the saluretic and renin-angiotensin responses to loop diuretics in the cat is unknown. We propose in vivo characterisation of isoform roles in a furosemide model by administering non-steroidal ...
A Hayes, B Mann, B Rose, B Rose, B Rose, CM Hao, DA Heller, DO Stichtenoth, F Catella-Lawson, F Nantel, G Giovanni, H Syme, H. Syme, J Hippisley-Cox, J Peti-Peterdi, J. Elliott, J. N. King, JA Jakobsen, K Schumacher, K. Smith, KA Kirchner, KL Therland, KN Khan, KN Khan, L Pelligand, L Pelligand, L. Pelligand, M Komhoff, M Meskell, M Sabbatini, N. Suemanotham, P. Lees, PA Friedman, RC Harris, RC Harris, RE Jepson, S Yu, V Campean, V Sreenivasan, VB Schmid, W. Seewald, WA Corsini, XR He   +42 more
core   +3 more sources