Results 91 to 100 of about 51,388 (286)
Smoking in inflammatory bowel diseases: Good, bad or ugly? [PDF]
, 2007 Smoking is an important environmental factor in inflammatory bowel disease (IBD), having different effects in ulcerative colitis (UC) and Crohn’s disease (CD).
Lakatos, László +2 more
core +1 more source
Flux Sampling Suggests Metabolic Signatures of High Antibody‐Producing CHO Cells
Biotechnology and Bioengineering, Volume 122, Issue 7, Page 1898-1913, July 2025.ABSTRACT Chinese hamster ovary (CHO) cells remain the industry standard for producing numerous therapeutic proteins, particularly monoclonal antibodies (mAbs). However, achieving higher recombinant protein titers remains an ongoing challenge and a fundamental understanding of the cellular mechanism driving improved bioprocess performance remains ...
Kate E. Meeson +9 more
wiley +1 more source
Journal of Lipid Research, 2003 Arachidonic acid inhibits adipocyte differentiation of 3T3-L1 cells via a prostaglandin synthesis-dependent pathway. Here we show that this inhibition requires the presence of a cAMP-elevating agent during the first two days of treatment.
Rasmus K. Petersen +8 more
doaj
Frataxin deficiency increases cyclooxygenase 2 and prostaglandins in cell and animal models of Friedreich's ataxia. [PDF]
, 2014 An inherited deficiency of the mitochondrial protein frataxin causes Friedreich's ataxia (FRDA); the mechanism by which this deficiency triggers neuro- and cardio-degeneration is unclear.
Cortopassi, Gino +5 more
core +1 more source
Redirecting Intermediary Metabolism to Counteract Cyanide Poisoning
The FASEB Journal, Volume 39, Issue 12, 30 June 2025.Cyanide is coined “the classic metabolic poison”; however, FDA‐approved cyanide chelators do not counteract cyanide's metabolic damage. Here, we review the mechanisms of cyanide toxicity, with a focus on intermediary metabolism. We present the theory that, within the innate plasticity of the metabolome, there may reside metabolic pathways that can ...
Vik S. Bebarta, Anjali K. Nath
wiley +1 more source
Journal of Lipid Research, 2015 Cytochrome P450 (CYP)-dependent eicosanoids comprise epoxy- and hydroxy-metabolites of long-chain PUFAs (LC-PUFAs). In mammals, CYP eicosanoids contribute to the regulation of cardiovascular and renal function. Caenorhabditis elegans produces a large set
Yiwen Zhou +4 more
doaj
An investigation into the effects of Omega-3 fatty acids on bone resorption in the female ovariectomised rat : a thesis presented in partial fulfillment of the requirements for the degree of Master of Science in Nutritional Science at Massey University [PDF]
, 2004 Estrogen deficiency results in disruption of the normal bone remodeling cyclc leading to a loss of bone mineral and, in many cases, the development of osteoporosis.
Poulsen, Raewyn Carol
core
The FASEB Journal, Volume 39, Issue 11, 15 June 2025.Ozone (O3) is a toxic air pollutant that causes respiratory inflammation and can cause hospitalization. The goal of this study was to determine if the G protein‐coupled receptor, ALX/FPR2, is required for the initiation of inflammation in the lungs following O3 exposure.
Michael J. Yaeger +16 more
wiley +1 more source
Journal of Lipid Research, 2018 Extracellular vesicles (EVs), such as exosomes and microvesicles, are small membrane-bound vesicles released by cells under various conditions. In a multitude of physiological and pathological conditions, EVs contribute to intercellular communication by ...
Eric Boilard
doaj
Egg Production and Quality of Magelang Duck Fed Diets Containing Different Ratio of Omega 3 : Omega 6 and Organic Zn [PDF]
, 2013 The aims of this study were to determine the feeding effect of diets containing different ratio of ω-3 and ω-6 fatty acids and organic Zn on egg production and quality of Magelang duck.
Darmawan, A. (A) +2 more
core