Results 141 to 150 of about 5,186,673 (318)
The FASEB Journal, Volume 40, Issue 2, 31 January 2026.TDP‐43 overexpressing mice, a genetic model of frontotemporal dementia, exhibit dramatic changes in their small intestinal endocannabinoidome members, in terms of both altered concentrations of lipid mediators and expression of some of their receptors (Cnr1, Gpr119, Gpr55, Pparg) and metabolic enzymes (Napepld, Faah). Also, the levels of some oxylipins
Hayatte‐Dounia Mir +9 more
wiley +1 more source
Three‐liquid‐phase salting‐out extraction of eicosapentaenoic acid (EPA) and docosahexaenoic acid (DHA)‐rich oils from Euphausia superba [PDF]
, 2021 Liaqat Zeb +5 more
openalex +1 more source
Gpx4 Deletion‐Mediated Macrophage Ferroptosis Alleviates Obesity‐Associated Insulin Resistance
The FASEB Journal, Volume 40, Issue 2, 31 January 2026.Macrophage‐specific loss of Gpx4 induces ferroptosis, thereby alleviating high‐fat diet (HFD)‐induced obesity, insulin resistance, and metabolic dysfunction, and conferring systemic metabolic protection in type 2 diabetes (T2D). ABSTRACT Obesity has become a global epidemic and a major contributor to the development of Type 2 diabetes (T2D) through the
Suhua Wu +13 more
wiley +1 more source
Advanced Science, Volume 13, Issue 2, 9 January 2026.In temporal lobe epilepsy, hippocampal APOE is markedly upregulated predominantly in microglia. APOE overexpression in microglia drives TLR4 and cGAS/STING‐dependent neuroinflammation, engages bidirectional crosstalk with neurons and astrocytes, increases neuronal excitability, and perturbs hippocampal lipid metabolism. These findings suggest that APOE‐
Jianwei Shi +10 more
wiley +1 more source
Novel C20 Conjugated Fatty Acids as Biohydrogenation Intermediates in Paraclostridium bifermentans
Journal of the American Oil Chemists' Society, Volume 103, Issue 1, Page 27-34, January 2026.ABSTRACT In this paper, we report a detailed characterization of the eicosapentaenoic acid (EPA) hydrogenation pathway in Paraclostridium bifermentans JCM 1386T, including the identification of novel intermediates of conjugated EPAs, cis‐5,cis‐8,cis‐11,trans‐13,cis‐17‐20:5 (CEPA1) and cis‐5,cis‐8,trans‐11,trans‐13,cis‐17‐20:5 (CEPA2) by nuclear ...
Juo‐Ying Chen +7 more
wiley +1 more source
ChemistryEurope, Volume 4, Issue 1, January 2026.Docosahexaenoic acid (DHA) synthase, a fatty acid synthase‐like large enzyme complex with multiple catalytic domains, possesses three dehydratase (DH) domains. In vitro analysis using acyl–acyl carrier protein (ACP) intermediates from all elongation cycles revealed that eukaryotic microalgal DHA synthase mainly uses the DH1FabA and DH2FabA domains ...
Tomoya Kawata +7 more
wiley +1 more source
Endocrinology, Diabetes &Metabolism, Volume 9, Issue 1, January 2026.The findings suggest a protective role of MUFA intake against CVDs risk. ABSTRACT Background Despite early interest in the effects of dietary fats on cardiovascular diseases (CVDs), substantial controversy remains regarding the evidence linking different types of fatty acids to CVDs.
Naeemeh Hassanpour Ardekanizadeh +12 more
wiley +1 more source
Supplementary Figure 2 from Regulation of Colorectal Cancer Cell Apoptosis by the n-3 Polyunsaturated Fatty Acids Docosahexaenoic and Eicosapentaenoic [PDF]
, 2023 Anna Girós +11 more
openalex +1 more source
Endocrinology, Diabetes &Metabolism, Volume 9, Issue 1, January 2026.Holothuria leucospilota n‐hexane extract shows antidiabetic, anti‐inflammatory, and anti‐apoptotic effects in STZ‐induced diabetic rats. The extract modulates key pathways in glucose metabolism, insulin secretion, inflammation, and apoptosis. Treatment significantly decreased glucose and amyloid beta levels, increased insulin, and improved glycemic ...
Niloufar Darbandi +1 more
wiley +1 more source