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EICOSAPENTAENOIC ACID AND PREVENTION OF THROMBOSIS AND ATHEROSCLEROSIS?
Lancet, The, 1978Unlike arachidonic acid (eicosatetraenoic acid, C20:4omega-6, A.A.), eicosapentaenoic acid (C20:5omega-3, E.P.A.) does not induce platelet aggregation in human platelet-rich plasma (P.R.P.), probably because of the formation of thromboxane A3 (T.X.A3) which does not have platelet aggregating properties.
J Dyerberg, H O Bang, E Stoffersen
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Immunomodulation of microglia by docosahexaenoic acid and eicosapentaenoic acid
Current Opinion in Clinical Nutrition and Metabolic Care, 2012The omega-3 fatty acids (ω-3 FAs) docosahexaenoic acid and eicosapentaenoic acid are dietary components which have been ascribed many different health benefits. Inflammation is present in, and contributes to, pathological conditions in the central nervous system (CNS).
Erik, Hjorth, Yvonne, Freund-Levi
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Eicosapentaenoic acid and chemoprevention of FAP
Gut, 2010In this issue of Gut , West et al 1 report positive results of a chemoprevention trial in British subjects with familial adenonomatous polyposis (FAP) ( see page 918 ). There is a long history of use of natural products in FAP and other adenoma prevention trials.2 4 In most cases the rationale seems predicated on notions of likely safety and ...
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Chain elongation of eicosapentaenoic acid in the macrophage
Biochimica et Biophysica Acta (BBA) - Lipids and Lipid Metabolism, 1990In order to elucidate the metabolic fate of eicosapentaenoic acid (20:5 (n-3], a major n-3 fatty acid constituent of fish oil, resident and casein-elicited mouse peritoneal macrophages were incubated with [3H]20:5 (n-3). Comparative experiments with arachidonic acid (20:4 (n-6] were also conducted.
R S, Chapkin, C C, Miller
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Production of Eicosapentaenoic Acid by Marine Bacteria
The Journal of Biochemistry, 1988About 5,000 strains of marine microorganisms were screened for eicosapentaenoic acid (EPA)-producing ability, which was detected in 88 of them. All of the latter were found to be obligate aerobic, Gram-negative, motile, short rod-shaped bacteria. One strain, designated as SCRC-8132, showed a doubling time of 30 min at 25 degrees C and produced 20 mg ...
K, Yazawa +7 more
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Heterotrophic production of eicosapentaenoic acid by microalgae
Biotechnology Advances, 2003Eicosapentaenoic acid (EPA) is an omega-3 polyunsaturated fatty acid that plays an important role in the regulation of biological functions and prevention and treatment of a number of human diseases such as heart and inflammatory diseases. As fish oil fails to meet the increasing demand for purified EPA, alternative sources are being sought. Microalgae
Wen, ZY, Chen, F
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Effect of eicosapentaenoic acid and docosahexaenoic acid on diabetic osteopenia
Diabetes Research and Clinical Practice, 1995To evaluate the effect of eicosapentaenoic acid (EPA) and docosahexaenoic acid (DHA), which are polyunsaturated fatty acids, on diabetic osteopenia, we measured the bone fragility in streptozotocin-induced diabetic rats. The fragility of femur was increased in diabetic rats, which was prevented in part by EPA or DHA.
Y, Yamada +8 more
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