Results 71 to 80 of about 1,625 (162)

A novel in vitro potency assay of antisera against Thai Naja kaouthia based on nicotinic acetylcholine receptor binding

Scientific Reports, 2017
Snake envenomation is an important medical problem. One of the hurdles in antivenom development is the in vivo assay of antivenom potency which is expensive, gives variable results and kills many animals.
Kavi Ratanabanangkoon, Pavinee Simsiriwong, Kritsada Pruksaphon, Kae Yi Tan, Sukanya Eursakun, Choo Hock Tan, Bunkuea Chantrathonkul, Wongsakorn Wongwadhunyoo, Sirida Youngchim, Nget Hong Tan   +9 more
doaj   +1 more source

Activity of two key toxin groups in Australian elapid venoms show a strong correlation to phylogeny but not to diet. [PDF]

BMC Evol Biol, 2020
Tasoulis T, Lee MSY, Ziajko M, Dunstan N, Sumner J, Isbister GK.   +5 more
europepmc   +1 more source

Aligning Post-Column ESI-MS, MALDI-MS, and Coagulation Bioassay Data of Naja spp., Ophiophagus hannah, and Pseudonaja textillis Venoms Chromatographically to Assess MALDI-MS and ESI-MS Complementarity with Correlation of Bioactive Toxins to Mass Spectrometric Data

Toxins
Snakebite is a serious health issue in tropical and subtropical areas of the world and results in various pathologies, such as hemotoxicity, neurotoxicity, and local swelling, blistering, and tissue necrosis around the bite site.
Haifeng Xu, Susan El-Asal, Hafsa Zakri, Rama Mutlaq, Natascha T. B. Krikke, Nicholas R. Casewell, Julien Slagboom, Jeroen Kool   +7 more
doaj   +1 more source

Anti-inflammatory peptides and proteins from venomous snakes: a short review

Journal of Biological Research
Inflammation can be acute or chronic. Chronic inflammation is a condition associated with several diseases like cardiovascular and neurodegenerative disorders, and even cancer.
Fernando Lazcano-Pérez, Adrián Marcelo Franco-Vásquez, Ayetza Mathob Rodríguez-García, Roberto Arreguin-Espinosa   +3 more
doaj   +1 more source

Antimicrobial Activity of Micrurus Venoms and Bioactive Films Functionalized with Purified L-Amino Acid Oxidase

Toxins
Phytopathogenic bacteria and fungi significantly reduce fruit and vegetable yields, resulting in substantial economic losses. Conventional management relies on synthetic agrochemicals; however, their intensive use poses risks to human health ...
Vitelbina Núñez Rangel, Paola Rey-Suárez, Daniel Buitrago-Chinchilla, Laura Reyes-Méndez, Leidy Gómez-Sampedro, Alejandro Carmona-Jiménez, Mateo Rivillas-Ochoa, Adriana Muñoz-Bravo   +7 more
doaj   +1 more source

Anticoagulant activity in Australasian elapid snake venoms and neutralisation with antivenom and varespladib

Toxicon
The venoms of Australasian elapid snakes are known to possess coagulant activity, including some with strong procoagulant activity and others with anticoagulant activity, although the latter are less well known. This study investigates the anticoagulant activity of Australasian elapid snake venoms, and whether this activity is neutralised by commercial
Kate Murphy, Theo Tasoulis, Nathan Dunstan, Geoffrey K. Isbister   +3 more
openaire   +2 more sources

Optimizing drug discovery for snakebite envenoming via a high-throughput phospholipase A2 screening platform

Frontiers in Pharmacology
Snakebite envenoming is a neglected tropical disease that causes as many as 1.8 million envenomings and 140,000 deaths annually. To address treatment limitations that exist with current antivenoms, the search for small molecule drug-based inhibitors that
Laura-Oana Albulescu, Laura-Oana Albulescu, Adam Westhorpe, Adam Westhorpe, Rachel H. Clare, Rachel H. Clare, Christopher M. Woodley, Nivya James, Jeroen Kool, Neil G. Berry, Paul M. O’Neill, Nicholas R. Casewell, Nicholas R. Casewell   +12 more
doaj   +1 more source

Nanotechnology-based paper microfluidics for rapid point-of-care detection and differentiation of snake venom types

Biosensors and Bioelectronics: X
Snake envenomation is recognized as a neglected tropical disease, contributing to high mortality rates and causing significant organ damage, particularly to the liver, kidneys, and brain.
Lakshmi Narashimhan Ramana, Nitin Salvi, M.V. Khadilkar, Tarun Kumar Sharma   +3 more
doaj   +1 more source

Standard Quality Characteristics and Efficacy of a New Third-Generation Antivenom Developed in Colombia Covering Micrurus spp. Venoms

Toxins
In Colombia, Micrurus snakebites are classified as severe according to the national clinical care guidelines and must be treated with specific antivenoms.
Santiago Tabares Vélez, Lina María Preciado, Leidy Johana Vargas Muñoz, Carlos Alberto Madrid Bracamonte, Angelica Zuluaga, Jeisson Gómez Robles, Camila Renjifo-Ibañez, Sebastián Estrada-Gómez   +7 more
doaj   +1 more source

Antigenic divergence of cobra short-chain α-neurotoxins: Implications for regional antivenom effectiveness in Southeast Asia. [PDF]

PLoS Negl Trop Dis
Tan CH, Palasuberniam P, Pernee LL, Tan KY.   +3 more
europepmc   +1 more source