Results 61 to 70 of about 5,729 (171)
FEBS Open Bio, Volume 16, Issue 8, Page 1491-1500, August 2026.Cytosolically synthesized chloroplast preproteins are translocated across the outer and inner envelope membranes through translocons called TOC and TIC, respectively. In green algae and plants, the TIC core is composed of essential membrane proteins, Tic12, Tic20, and Tic214.
Mengyi Li, Xueyang Zhao, Masato Nakai
wiley +1 more source
Pharmaceutics, 2020 Electroporation—a transient electric-field-induced increase in cell membrane permeability—can be used to facilitate the delivery of anticancer drugs for antitumour electrochemotherapy.
Diana Navickaite +6 more
doaj +1 more source
An Integrated DNA Nanoprobe for Intranuclear Imaging and In Situ Profiling of OGG1 Activity
Advanced Science, Volume 13, Issue 47, 24 August 2026.The TP‐SA nanoprobe, integrating an AS1411 aptamer for nuclear delivery and a FRET array for signal amplification, enables real‐time tracking of nuclear OGG1 activity. It reveals cell‐line‐specific basal OGG1 levels and shows clinical promise using pneumonia patients’ lavage fluid.
Mingzhu Zhao +9 more
wiley +1 more source
LNA-based Oligonucleotide Electrotransfer for miRNA Inhibition [PDF]
Molecular Therapy, 2012 Micro-RNAs (miRNAs) are small regulatory RNAs that play an important role in disease development and progression and therefore represent a potential new class of therapeutic targets. However, an effective and safe clinical approach for miRNA inhibition remains elusive, primarily due to the lack of effective delivery methods.
Orio, Julie +6 more
openaire +2 more sources
PLoS ONE, 2023 We investigated gene electrotransfer using electrical short-circuiting via a cell suspension droplet in dielectric oil. An aqueous droplet of a few microliters placed between a pair of electrodes can be deformed by an intense DC electric field depending ...
Yoshino Tsurusaki +4 more
doaj +1 more source
Clinical and Translational Medicine, Volume 16, Issue 8, August 2026.CD155 is identified as a key driver of anti‐PD‐1 resistance in NSCLC. CD155 promotes tumour glycolysis and malignant progression via the PI3K/AKT/HIF‐1α signalling axis. AAV9_shCD155 combined with anti‐PD‐1 markedly inhibits tumour growth and promotes immune infiltration. Abstract Objective Anti‐PD‐1 therapy resistance remains a critical barrier in non‐
Wei‐Guang Du +11 more
wiley +1 more source
Veterinary Medicine and Science, Volume 12, Issue 4, July 2026.Betaine alleviated NEFA‐induced oxidative stress, which served as a central mechanistic link between fatty liver and mammary dysfunction, and concurrently improved milk protein synthesis via regulation of the Nrf2‐JAK2/STAT5/mTOR axis. ABSTRACT Background Fatty liver is highly prevalent in dairy cows and poses a significant challenge to the dairy ...
Wenyan Yan +6 more
wiley +1 more source
Radiology and Oncology, 2017 The study was aimed to characterize tumor response after combined treatment employing electrochemotherapy with IL-12 gene electrotransfer in dogs with spontaneous mast cell tumors (MCT).
Salvadori Claudia +9 more
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Aging Cell, Volume 25, Issue 7, July 2026.GW9508 activates GPR40 to trigger Ca2+ influx and AMPKα signaling, repressing ERK1/2‐MAPK cascade. This pathway alleviates thymic epithelial cell senescence and restores T cell production to counteract thymus aging. ABSTRACT Age‐associated thymic involution leads to a reduction of T‐cell production, which constitutes a primary factor in ...
Qingqing Li +11 more
wiley +1 more source
Advanced Science, Volume 13, Issue 34, 19 June 2026.In colorectal cancer, high expression of the DNA repair protein EEPD1 correlates with immune exclusion and poor prognosis. This study demonstrates that EEPD1 depletion induces genomic instability, leading to cytosolic DNA accumulation and subsequent activation of the cGAS‐STING‐type I interferon pathway. This cascade remodels the tumor microenvironment
Liyun Huo +8 more
wiley +1 more source