Results 51 to 60 of about 5,598 (174)

Calcium Electroporation of Equine Sarcoids

open access: yesAnimals, 2020
Sarcoids are common equine skin tumors where the risk of recurrence after treatment is high, and better treatment options are warranted. Calcium electroporation is a novel anti-cancer treatment where lethally high calcium concentrations are introduced ...
Stine K. Frandsen   +3 more
doaj   +1 more source

EEPD1 Inhibition Unleashes Antitumor Immunity in Colorectal Cancer by Activating the cGAS‐STING Pathway

open access: yesAdvanced Science, Volume 13, Issue 34, 19 June 2026.
In colorectal cancer, high expression of the DNA repair protein EEPD1 correlates with immune exclusion and poor prognosis. This study demonstrates that EEPD1 depletion induces genomic instability, leading to cytosolic DNA accumulation and subsequent activation of the cGAS‐STING‐type I interferon pathway. This cascade remodels the tumor microenvironment
Liyun Huo   +8 more
wiley   +1 more source

Computational Simulation Expands Understanding of Electrotransfer-Based Gene Augmentation for Enhancement of Neural Interfaces

open access: yesFrontiers in Neuroscience, 2019
The neural interface is a critical factor in governing efficient and safe charge transfer between a stimulating electrode and biological tissue. The interface plays a crucial role in the efficacy of electric stimulation in chronic implants and both ...
Amr Al Abed   +6 more
doaj   +1 more source

Aluminum particles generated during millisecond electric pulse application enhance adenovirus-mediated gene transfer in L929 cells

open access: yesScientific Reports, 2021
Gene electrotransfer is an attractive method of non-viral gene delivery. However, the mechanism of DNA penetration across the plasma membrane is widely discussed.
Angela Tesse   +2 more
doaj   +1 more source

Structural Characterization of Ginseng Adventitious Root Polysaccharides and Their Effects on Ameliorating Insulin Resistance

open access: yeseFood, Volume 7, Issue 3, June 2026.
Purified ginseng adventitious root polysaccharides (GARP) improve insulin resistance by enhancing glucose and lipid metabolism and reducing oxidative stress. These beneficial effects are mediated, at least in part, through activation of the Nrf2/Keap1 signaling pathway in cellular and animal models.
Tian‐fu Yang   +5 more
wiley   +1 more source

Ultra‐Pulsed Fractional CO2 Laser Combined With Stromal Vascular Fraction Gel: Synergistic Effects and Underlying Mechanisms in Depressed Scars

open access: yesJournal of Cosmetic Dermatology, Volume 25, Issue 6, June 2026.
ABSTRACT Objective To investigate the therapeutic efficacy and underlying molecular mechanisms of stromal vascular fraction gel (SVF‐gel) combined with ultra‐pulsed fractional CO2 laser (UFCL) in the treatment of depressed scars. Methods A rat model of depressed scars was established by full‐thickness excision of dorsal skin.
Lei Chen, Lingling Liu, Qunqun Jiang
wiley   +1 more source

Electroporation as the Immunotherapy Strategy for Cancer in Veterinary Medicine: State of the Art in Latin America

open access: yesVaccines, 2020
Electroporation is a technology that increases cell membrane permeability by the application of electric pulses. Electrochemotherapy (ECT), the best-known application of electroporation, is a very effective local treatment for tumors of any histology in ...
Felipe Maglietti   +6 more
doaj   +1 more source

Biosensors for Alzheimer's Disease Detection and Monitoring: Bridging Preclinical and Clinical Applications

open access: yesAnalysis &Sensing, Volume 6, Issue 3, May 2026.
This review summarizes recent advances in biosensing technologies for Alzheimer's disease, including immunosensors, aptasensors, and hybrid platforms. Emphasis is placed on both the incorporation of nanomaterials, which enhance electron transfer, biomolecule immobilization, and signal amplification, enabling femtomolar detection, and the role of ...
Denisa‐Nicoleta Voicila   +2 more
wiley   +1 more source

Extracellular-Ca2+-Induced Decrease in Small Molecule Electrotransfer Efficiency: Comparison between Microsecond and Nanosecond Electric Pulses

open access: yesPharmaceutics, 2020
Electroporation—a transient electric-field-induced increase in cell membrane permeability—can be used to facilitate the delivery of anticancer drugs for antitumour electrochemotherapy.
Diana Navickaite   +6 more
doaj   +1 more source

LNA-based Oligonucleotide Electrotransfer for miRNA Inhibition [PDF]

open access: yesMolecular Therapy, 2012
Micro-RNAs (miRNAs) are small regulatory RNAs that play an important role in disease development and progression and therefore represent a potential new class of therapeutic targets. However, an effective and safe clinical approach for miRNA inhibition remains elusive, primarily due to the lack of effective delivery methods.
Orio, Julie   +6 more
openaire   +2 more sources

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