Results 1 to 10 of about 848,551 (267)

LncRNA GAS5-hnRNPK axis inhibited ovarian cancer progression via inhibition of AKT signaling in ovarian cancer cells

Discover Oncology, 2023
Background The incidence of ovarian cancer ranks third among gynecologic malignancies, but the mortality rate ranks first. Methods The expression of GAS5 is low in ovarian cancer and is associated with the low survival of ovarian cancer patients ...
Te Zhang, Yahui Leng, Mengjing Duan, Zihang Li, Yongqing Ma, Chengyang Huang, Qin Shi, Yi Wang, Chengcheng Wang, Dandan Liu, Xuan Zhao, Shuang Cheng, Ao Liu, Yang Zhou, Jiaqi Liu, Zhongqiu Pan, Huimei Zhang, Li Shen, Hongyan Zhao   +18 more
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NSUN2 alleviates doxorubicin-induced myocardial injury through Nrf2-mediated antioxidant stress

Cell Death Discovery, 2023
Doxorubicin (DOX) is a commonly used antitumor drug, but its application has been limited because of its strong cardiac damage. This study aims to explore the role of NSUN2 in DOX-induced heart injury.
Yi Wang, Yuxin Zan, Yingying Huang, Xiaoyun Peng, Shinan Ma, Ji Ren, Xiao Li, Lin Wei, Xiaoli Wang, Yahong Yuan, Junming Tang, Zhongqun Zhan, Zhixiao Wang, Yan Ding   +13 more
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Spatio-temporal model of Meox1 expression control involvement of Sca-1-positive stem cells in neointima formation through the synergistic effect of Rho/CDC42 and SDF-1α/CXCR4

Stem Cell Research & Therapy, 2021
Aims Neointimal hyperplasia remains a major obstacle in vascular regeneration. Sca-1-positive progenitor cells residing within the vascular adventitia play a crucial role in the assemblage of vascular smooth muscle cell (VSMC) and the formation of the ...
Yan Wu, Yuan-jin Li, Liu-liu Shi, Yun Liu, Yan Wang, Xin Bao, Wei Xu, Lu-yuan Yao, Magdaleena Naemi Mbadhi, Long Chen, Shan Li, Xing-yuan Li, Zhi-feng Zhang, Sen Zhao, Ruo-nan Zhang, Shi-You Chen, Jing-xuan Zhang, Jun-mingTang   +17 more
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Effects of Luteolin-7-O-Glucoside on Intestinal Microbiota Dysbiosis and Drug Resistance Transmission Caused by Raoultella ornithinolytica B1645-1: Modulating the Composition of Intestinal Microbiota and Promoting the Transfer of bla_NDM-1 Gene from Genus Enterococcus to Lactobacillus in Mice

Microorganisms, 2023
Raoultella ornithinolytica is an Enterobacteriaceae bacterium that can infect both humans and animals, while luteolin-7-O-glucoside (IOG) is a flavonoid that has broad effects on the intestinal microbiota of healthy animals. However, current studies lack
Zhaomeng Wu, Ronghui Gou, Longhua Sha, Chunfang Yu, Lixue Meng, Zhixiong Jin   +5 more
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miRNA‐194 predicts favorable prognosis in gastric cancer and inhibits gastric cancer cell growth by targeting CCND1

FEBS Open Bio, 2021
MicroRNAs (MiRNAs) play critical roles in regulating target gene expression and multiple cellular processes in human cancer malignant progression. However, the function of miR‐194 in gastric cancer (GC) remains unclear and controversial.
Jingjie Wang, Meixin Zhang, Xinhui Hu, Jiajun She, Ruonan Sun, Shanshan Qin, Dandan Li   +6 more
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Qiliqiangxin reduced cardiomyocytes apotosis and improved heart function in infarcted heart through Pink1/Parkin -mediated mitochondrial autophagy

BMC Complementary Medicine and Therapies, 2020
Background Qiliqiangxin (QLQX) is a preparation refined from a traditional Chinese medicine compound. It plays an important role in protecting cardiac function after myocardial infarction (MI). However, the underline mechanism of QLQX action is not clear.
Junyang Zhou, Zhixiao Wang, Yun He, Xinxia Luo, Wenjun Zhang, Li Yu, Xiuying Chen, Xiju He, Yahong Yuan, Xiaoli Wang, Xinrong Guo, Junming Tang, Mingan Zhu, Dongsheng Li, Yan Ding   +14 more
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An Efficient and Footprint-Free Protocol for the Transdifferentiation of Hepatocytes Into Insulin-Producing Cells With IVT mRNAs

Frontiers in Genetics, 2020
BackgroundDirect transdifferentiation of adult somatic cells into insulin-producing cells (IPCs) is a promising approach for cell-based therapies for type 1 diabetes mellitus.
Shinan Ma, Mengjie Yang, Mengjie Yang, Wenhui Zhou, Longjun Dai, Longjun Dai, Yan Ding, Xingrong Guo, Yahong Yuan, Junming Tang, Dongsheng Li, Xiaoli Wang   +11 more
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Generation of C57BL/6 knockout mice using C3H × BALB/c blastocysts

BioTechniques, 2008
The International Mouse Knockout Consortium aims to generate a knockout mouse for every single gene on a C57BL/6 background. Our ability to generate such mice is hampered by the poor economics of producing blastocysts to achieve germline transmission of ...
Gabriela Pacholczyk, Rupali Suhag, Magdalena Mazurek, Suzanne M. Dederscheck, Pandelakis A. Koni   +4 more
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ANGPTL8 promotes adipogenic differentiation of mesenchymal stem cells: potential role in ectopic lipid deposition

Frontiers in Endocrinology, 2022
BackgroundEctopic lipid deposition plays a promoting role in many chronic metabolic diseases. Abnormal adipogenic differentiation of mesenchymal stem cells (MSCs) is an important cause of lipid deposition in organs.
Jian Tang, Jian Tang, Shinan Ma, Yujiu Gao, Fan Zeng, Ying Feng, Chong Guo, Lin Hu, Lingling Yang, Lingling Yang, Yanghui Chen, Qiufang Zhang, Yahong Yuan, Xingrong Guo, Xingrong Guo   +14 more
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ANGPTL8 is a negative regulator in pathological cardiac hypertrophy

Cell Death and Disease, 2022
Pathological cardiac hypertrophy is an independent risk factor for heart failure and is considered a target for the treatment of heart failure. However, the mechanisms underlying pathological cardiac hypertrophy remain largely unknown.
Lin Hu, Jiarui Wei, Yue Zhang, Ziyuan Wang, Junming Tang, Jian Tang, Yujiu Gao, Xiaoqiao Zhang, Yifan Li, Yantong Liu, Shinan Ma, Xingrong Guo, Qiufang Zhang   +12 more
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