Results 31 to 40 of about 1,383,394 (337)

Single-cell RNA-seq reveals novel regulators of human embryonic stem cell differentiation to definitive endoderm

Genome Biology, 2016
Human pluripotent stem cells offer the best available model to study the underlying cellular and molecular mechanisms of human embryonic lineage specification.
Li-Fang Chu, Ning Leng, Jue Zhang, Zhonggang Hou, Daniel Mamott, D. Vereide, Jeea Choi, C. Kendziorski, R. Stewart, J. Thomson   +9 more
semanticscholar   +1 more source

Primate Primordial Germ Cells Acquire Transplantation Potential by Carnegie Stage 23. [PDF]

, 2017
Primordial germ cells (PGCs) are the earliest embryonic progenitors in the germline. Correct formation of PGCs is critical to reproductive health as an adult.
Chen, Di, Clark, Amander T, Gkountela, Sofia, Hennebold, Jon D, Liu, Wanlu, Orwig, Kyle E, Sosa, Enrique, Sukhwani, Meena   +7 more
core   +2 more sources

Reprogramming Malignant Cancer Cells toward a Benign Phenotype following Exposure to Human Embryonic Stem Cell Microenvironment

PLoS ONE, 2017
The embryonic microenvironment is well known to be non-permissive for tumor development because early developmental signals naturally suppress the expression of proto-oncogenes.
Shufeng Zhou, M. Abdouh, V. Arena, M. Arena, G. Arena   +4 more
semanticscholar   +1 more source

Stem Cells from a Biological Perspective in Animals: A Review [PDF]

, 2017
Cells are the smallest living units of living system. Stem cells are undifferentiated biological cells that can differentiate into specialized cells and can divide to produce more stem cells.
Jain, A. (Archana), Khan, M. A. (M), Shakkarpude, J. (J)   +2 more
core   +1 more source

MELK-a conserved kinase: functions, signaling, cancer, and controversy. [PDF]

, 2015
Maternal embryonic leucine zipper kinase (MELK) is a highly conserved serine/threonine kinase initially found to be expressed in a wide range of early embryonic cellular stages, and as a result has been implicated in embryogenesis and cell cycle control.
Beullens, Monique, Ganguly, Ranjit, Kornblum, Harley I, Mohyeldin, Ahmed, Nakano, Ichiro, Thiel, Jordyn   +5 more
core   +2 more sources

Organoids in pediatric cancer research

FEBS Letters, EarlyView.
Organoid technology has revolutionized cancer research, yet its application in pediatric oncology remains limited. Recent advances have enabled the development of pediatric tumor organoids, offering new insights into disease biology, treatment response, and interactions with the tumor microenvironment.
Carla Ríos Arceo, Jarno Drost
wiley   +1 more source

Association between Interleukin-10 Gene Polymorphisms and Behcet’s Disease Susceptibility: Evidence from a Meta-Analysis

Journal of Immunology Research, 2020
Epidemiological studies have demonstrated that interleukin-10 (IL-10) polymorphisms may be associated with the development of Behcet’s disease (BD). However, the published results were inconsistent. Therefore, this meta-analysis was conducted to derive a
Xue-Feng Li, Zhi-Zhen Huang, Yuan-Yuan Hu, Yu-Ming Niu, Jun-Wei Cai   +4 more
doaj   +1 more source

Tracking the embryonic stem cell transition from ground state pluripotency

Development, 2016
Mouse embryonic stem (ES) cells are locked into self-renewal by shielding from inductive cues. Release from this ground state in minimal conditions offers a system for delineating developmental progression from naïve pluripotency.
Tüzer Kalkan, Nelly N Olova, M. Roode, C. Mulas, Heather J. Lee, Isabelle Nett, H. Marks, Rachael Walker, H. Stunnenberg, K. Lilley, J. Nichols, W. Reik, P. Bertone, A. Smith   +13 more
semanticscholar   +1 more source

The role of fibroblast growth factors in cell and cancer metabolism

FEBS Letters, EarlyView.
Fibroblast growth factor (FGF) signaling regulates crucial signaling cascades that promote cell proliferation, survival, and metabolism. Therefore, FGFs and their receptors are often dysregulated in human diseases, including cancer, to sustain proliferation and rewire metabolism.
Jessica Price, Chiara Francavilla
wiley   +1 more source

Stem Cell Therapeutics: Exploring Newer Alternatives to Human Embryonic Stem Cells [PDF]

, 2008
Stem cells therapeutics has come a long way since stem cells and their potential was discovered for the first time. Intense research into cellular biology of stem cells has revealed that they possess immense potential for curing many human diseases ...
Garg, Abhishek D.
core