Results 31 to 40 of about 1,293,017 (382)

Direct comparison of distinct naive pluripotent states in human embryonic stem cells [PDF]

, 2017
Until recently, human embryonic stem cells (hESCs) were shown to exist in a state of primed pluripotency, while mouse embryonic stem cells (mESCs) display a naive or primed pluripotent state.
Chuva de Sousa Lopes, Susana Marina, De Coninck, Dieter, De Sutter, Petra, Deforce, Dieter, Duggal, Galbha, Heindryckx, Björn, Lierman, Sylvie, Menten, Björn, Mestdagh, Pieter, Peelman, Luc, Popovic, Mina, Sutherland, Ella, Taelman, Jasin, Tilleman, Laurentijn, Van der Jeught, Margot, Van Nieuwerburgh, Filip, Van Soom, Ann, Vandesompele, Jo, Warrier, Sharat   +18 more
core   +1 more source

Embryonic stem cell proteomics

Expert Review of Proteomics, 2006
Human embryonic stem cells potentially represent an unlimited source of cells and tissues for regenerative medicine. Understanding signaling events that drive proliferation and specialization of these cells into various differentiated derivatives is of utmost importance for controlling their behavior in vitro. Major progress has been made in unraveling
van Hoof, D., Mummery, C.L., Heck, A.J.R., Krijgsveld, J.   +3 more
openaire   +5 more sources

Single-cell RNA-seq reveals novel regulators of human embryonic stem cell differentiation to definitive endoderm

Genome Biology, 2016
Human pluripotent stem cells offer the best available model to study the underlying cellular and molecular mechanisms of human embryonic lineage specification.
Li-Fang Chu, Ning Leng, Jue Zhang, Zhonggang Hou, Daniel Mamott, D. Vereide, Jeea Choi, C. Kendziorski, R. Stewart, J. Thomson   +9 more
semanticscholar   +1 more source

An Opposite Effect of the CDK Inhibitor, p18^INK4c on Embryonic Stem Cells Compared with Tumor and Adult Stem Cells [PDF]

, 2012
Self-renewal is a feature common to both adult and embryonic stem (ES) cells, as well as tumor stem cells (TSCs). The cyclin-dependent kinase inhibitor, p18INK4c, is a known tumor suppressor that can inhibit self-renewal of tumor cells or adult stem ...
Cindy Tian, Haizhong Feng, Li-Ying Sung, Rekha Pal, Shi-Yuan Cheng, Tadayuki Akagi, Tao Cheng, Weimin Miao, Yanxin Li   +8 more
core   +8 more sources

Serine protease PRSS56, a novel cancer-testis antigen activated by DNA hypomethylation, promotes colorectal and gastric cancer progression via PI3K/AKT axis

Cell & Bioscience, 2023
Background Cancer/testis (CT) antigens/genes are usually overexpressed in cancers and exhibit high immunogenicity, making them promising targets for immunotherapy and cancer vaccines. The role of serine protease PRSS56 in cancers remains unknown to date.
Dandan Li, Lingyun Xia, Pan Huang, Zidi Wang, Qiwei Guo, Congcong Huang, Weidong Leng, Shanshan Qin   +7 more
doaj   +1 more source

The Liberation of Embryonic Stem Cells

PLoS Genetics, 2011
Mouse embryonic stem (ES) cells are defined by their capacity to self-renew and their ability to differentiate into all adult tissues including the germ line. Along with efficient clonal propagation, these properties have made them an unparalleled tool for manipulation of the mouse genome.
Kathryn Blair, Austin Smith, Jason Wray
openaire   +5 more sources

Hypoxia Signaling Pathway in Stem Cell Regulation: Good and Evil [PDF]

, 2018
Purpose of Review: This review summarizes the role of hypoxia and hypoxia-inducible factors (HIFs) in the regulation of stem cell biology, specifically focusing on maintenance, differentiation, and stress responses in the context of several stem cell ...
Aljoufi, Arafat, Broxmeyer, Hal E., Huang, Xinxin, Trinh, Thao   +3 more
core   +1 more source

Integrin-Associated Focal Adhesion Kinase Protects Human Embryonic Stem Cells from Apoptosis, Detachment, and Differentiation

Stem Cell Reports, 2016
Human embryonic stem cells (hESCs) can be maintained in a fully defined niche on extracellular matrix substrates, to which they attach through integrin receptors.
Loriana Vitillo, Melissa Baxter, Banu Iskender, Paul Whiting, Susan J. Kimber   +4 more
doaj   +1 more source

Democracy Derived? New Trajectories in Pluripotent Stem Cell Research [PDF]

, 2011
How has the development of human induced pluripotent stem cells (hiPSCs) modified the trajectory of stem cell research? Here, coauthorship networks of stem cell research articles and analysis of cell lines used in stem cell research indicate that hiPSCs ...
DeRouen, Mindy C., McCormick, Jennifer B., Owen-Smith, Jason, Scott, Christopher Thomas   +3 more
core   +1 more source

Stem cells in the embryonic kidney [PDF]

Kidney International, 2008
The mammalian kidney, the metanephros, is formed by a reciprocally inductive interaction between two precursor tissues, the metanephric mesenchyme and the ureteric bud. The ureteric bud induces the metanephric mesenchyme to differentiate into the epithelia of glomeruli and renal tubules.
openaire   +3 more sources