Results 31 to 40 of about 848,551 (267)

VEGF-B-mediated myofiber types involved in high-fat diet-induced hyperglycemia through PKA-NFATs signaling pathway

Stem Cell Research & Therapy
Background Hyperglycemia and insulin resistance are among the key phenotypes of obesity and type 2 diabetes (T2DM). Notably, skeletal muscle fiber-type composition is closely linked to insulin resistance. Vascular endothelial growth factor B (VEGF-B) has
Liu-liu Shi, Yu-ting Sun, Jia-nan Sun, Jing Yue, Wei Chen, Kun Meng, Long Chen, Chang-qing Hu, Rui Chen, Dong-sheng Sun, Cheng-bao Xu, Wei Yuan, Xin-li Li, Dan Zhao, Yan Wu, Shi-bing Xi, Xiao-ying Zhao, Jun-ming Tang   +17 more
doaj   +1 more source

The EMT-induced lncRNA NR2F1-AS1 positively modulates NR2F1 expression and drives gastric cancer via miR-29a-3p/VAMP7 axis

Cell Death and Disease, 2022
Deregulated lncRNAs play critical roles in tumorigenesis and tumor progression. NR2F1-AS1 is an antisense lncRNA of NR2F1. However, the biological function of NR2F1-AS1 in gastric cancer (GC) remains largely unclear. In this study, we revealed that NR2F1-
Dandan Li, Mengjie Xu, Zidi Wang, Pan Huang, Congcong Huang, Zhen Chen, Gaijuan Tang, Xingji Zhu, Mengyu Cai, Shanshan Qin   +9 more
doaj   +1 more source

Modeling hepatic fibrosis in TP53 knockout iPSC‐derived human liver organoids

Molecular Oncology, EarlyView.
This study developed iPSC‐derived human liver organoids with TP53 gene knockout to model human liver fibrosis. These organoids showed elevated myofibroblast activation, early disease markers, and advanced fibrotic hallmarks. The use of profibrotic differentiation medium further amplified the fibrotic signature seen in the organoids.
Mustafa Karabicici, Soheil Akbari, Ceyda Caliskan, Canan Celiker, Ozden Oz, Leman Binokay, Gökhan Karakulah, Serif Senturk, Esra Erdal   +8 more
wiley   +1 more source

Metformin inhibits the growth of SCLC cells by inducing autophagy and apoptosis via the suppression of EGFR and AKT signalling

Scientific Reports
Small cell lung cancer (SCLC) is a therapeutically challenging disease. Metformin, an effective agent for the treatment of type 2 diabetes, has been shown to have antitumour effects on many cancers, including non-small cell lung cancer (NSCLC) and breast
Hong Xia, Xue-jiao Tai, Wang Cheng, Yi Wu, Dan He, Li-feng Wang, Hao Liu, Shen-yi Zhang, Yu-ting Sun, Hang-zhi Liu, Dan-dan Liu, Hu-zi Zhao, Fu-yun Ji, Xi-hua Li   +13 more
doaj   +1 more source

Characterization of the Molecular Diversity and Degranulation Activity of Mastoparan Family Peptides from Wasp Venoms

Toxins, 2023
Wasp stings have become an increasingly serious public health problem because of their high incidence and mortality rates in various countries and regions.
Xiangdong Ye, Xin Liu, Xudong Luo, Fang Sun, Chenhu Qin, Li Ding, Wen Zhu, Huajun Zhang, Haimei Zhou, Zongyun Chen   +9 more
doaj   +1 more source

Adaptaquin is selectively toxic to glioma stem cells through disruption of iron and cholesterol metabolism

Molecular Oncology, EarlyView.
Adaptaquin selectively kills glioma stem cells while sparing differentiated brain cells. Transcriptomic and proteomic analyses show Adaptaquin disrupts iron and cholesterol homeostasis, with iron chelation amplifying cytotoxicity via cholesterol depletion, mitochondrial dysfunction, and elevated reactive oxygen species.
Adrien M. Vaquié, Davod R. Shah, Eliane E. S. Brechbühl, Michael McNicholas, Zhaoyang Xu, John H. Stockley, Laura Morcom, Diana Gold Diaz, Gemma C. Girdler, Rachel V. Seear, Gabriel Balmus, Rajiv R. Ratan, Harry Bulstrode, James A. Nathan, Manav Pathania, Kevin M. Brindle, David H. Rowitch   +16 more
wiley   +1 more source

The metabolome regulates the epigenetic landscape during naïve to primed human embryonic stem cell transition

Nature Cell Biology, 2015
For nearly a century developmental biologists have recognized that cells from embryos can differ in their potential to differentiate into distinct cell types.
Henrik Sperber, J. Mathieu, Yuliang Wang, A. Ferreccio, Jennifer Hesson, Zhuojin Xu, Karin A. Fischer, A. Devi, A. Devi, Damien Detraux, Haiwei Gu, S. Battle, Megan Showalter, C. Valensisi, J. Bielas, J. Bielas, Nolan G. Ericson, L. Margaretha, A. Robitaille, D. Margineantu, O. Fiehn, O. Fiehn, D. Hockenbery, C. Blau, D. Raftery, D. Raftery, Adam A. Margolin, R. D. Hawkins, R. Moon, R. Moon, C. Ware, H. Ruohola-Baker   +31 more
semanticscholar   +1 more source

The neural crest‐associated gene ERRFI1 is involved in melanoma progression and resistance toward targeted therapy

Molecular Oncology, EarlyView.
ERRFI1, a neural crest (NC)‐associated gene, was upregulated in melanoma and negatively correlated with the expression of melanocytic differentiation markers and the susceptibility of melanoma cells toward BRAF inhibitors (BRAFi). Knocking down ERRFI1 significantly increased the sensitivity of melanoma cells to BRAFi.
Nina Wang, Qian Sun, Daniel Novak, Lei Zhu, Juliane Poelchen, Tamara Steinfass, Yiman Wang, Viktor Umansky, Jochen Utikal   +8 more
wiley   +1 more source

Cytoplasmic p21 promotes stemness of colon cancer cells via activation of the NFκB pathway

Molecular Oncology, EarlyView.
Cytoplasmic p21 promotes colorectal cancer stem cell (CSC) features by destabilizing the NFκB–IκB complex, activating NFκB signaling, and upregulating BCL‐xL and COX2. In contrast to nuclear p21, cytoplasmic p21 enhances spheroid formation and stemness transcription factor CD133.
Arnatchai Maiuthed, Kerstin Huebner, Katharina Erlenbach‐Wuensch, Chuanpit Hampel, Daniela Thalheim, Adriana Vial‐Roehe, Bodee Nutho, Susanne Merkel, Arndt Hartmann, Pithi Chanvorachote, Regine Schneider‐Stock   +10 more
wiley   +1 more source

RIPK3 Suppresses the Progression of Spontaneous Intestinal Tumorigenesis

Frontiers in Oncology, 2021
Receptor-interacting protein 3 (RIPK3), a member of the family of serine/threonine protein kinases, emerged as a critical regulator of necroptosis. Downregulated expression of RIPK3 is correlated with poor prognosis in multiple tumor types. Here, we show
Qun Zhao, Jian Guo, Xinran Cheng, Yingying Liao, Yun Bi, Yingxia Gong, Xudong Zhang, Yang Guo, Xianhui Wang, Wei Yu, Shu Jin, Yan Tan, Xianjun Yu   +12 more
doaj   +1 more source