Results 191 to 200 of about 1,274,889 (380)

Electrical Stimulation Therapy – Dedicated to the Perfect Plastic Repair

Advanced Science, EarlyView.
This review discusses various types of electrical stimulation sources and materials, delving into the roles and mechanisms of electrical stimulation therapy in plastic surgery for tissue repair. This work broadens the clinical perspective of electrical stimulation, covering diverse repair needs from bone to soft tissues, and provides insights into ...
Kexin Deng, Ruizeng Luo, Ying Chen, Xiaoqiang Liu, Yuanyin Xi, Muhammad Usman, Xupin Jiang, Zhou Li, Jiaping Zhang   +8 more
wiley   +1 more source

The Reconstruction of Peripheral Auditory Circuit: Recent Advances and Future Challenges

Advanced Science, EarlyView.
This paper summarizes the potential of biomaterials, stem cells, and gene editing technologies in the regeneration of inner ear hair cells, spiral ganglion neurons, and inner ear organoids. Challenges and potential developments are discussed and explored.
Zhe Li, Ying Zhang, Zhenyu Xiao, Jieyu Qi   +3 more
wiley   +1 more source

X‐Linked Gene Dosage and SOX2 Act as Key Roadblocks for Human Germ Cell Specification in Klinefelter Syndrome

Advanced Science, EarlyView.
Klinefelter syndrome‐derived iPSCs provide an excellent model for studying X chromosome inactivation and functions of escapee genes during human primordial germ cell‐like cells differentiation process. Downregulation of three X‐linked genes—IGSF1, CHRDL1, and USP9X—significantly enhances the efficiency of hPGCLCs.
Wenteng He, Qing Luo, Jian Zhao, Mengting Wang, Allan Zhao, Luohua Feng, Ahmed Reda, Eva Lindgren, Jan‐Bernd Stukenborg, Jiayu Chen, Qiaolin Deng   +10 more
wiley   +1 more source

Deciphering Auditory Hyperexcitability in Otogl Mutant Mice Unravels an Auditory Neuropathy Mechanism

Advanced Science, EarlyView.
By investigating auditory hyperexcitability in a mouse model for hereditary deafness, this study identified a subpopulation of afferent neurons of the auditory nerve marked by Otogl expression. Despite their apparently normal hearing, Otogl+/− mice display poor activation of afferent neurons processing loud sounds and an elevation of the middle the ear
Mathilde Gagliardini, Sabrina Mechaussier, Carolina Campos Pina, Monica Morais, Olivier Postal, Philippe Jean, Typhaine Dupont, Amrit Singh‐Estivalet, Shéhanie Udugampolage, Cyril Scandola, Elisabeth Verpy, Baptiste Libé‐Philippot, Talya C. Inbar, Joanna Schwenkgrub, Carla Maria Barbosa Spinola, Raphaël Etournay, Aziz El‐Amraoui, Brice Bathellier, Adeline Mallet, Sedigheh Delmaghani, Fabrice Giraudet, Christine Petit, Boris Gourévitch, Paul Avan, Nicolas Michalski   +24 more
wiley   +1 more source

N6-methyladenosine modification destabilizes developmental regulators in embryonic stem cells

Nature Cell Biology, 2014
Yang Wang, Yue Li, J. Toth, M. Petroski, Zhaolei Zhang, Jing Crystal Zhao   +5 more
semanticscholar   +1 more source

Production of a germ-line chimeric mouse derived from newly established embryonic stem cells.

, 1991
Sadahiro Azuma, Yutaka Toyoda
openalex   +2 more sources

Expression of AML1-d, a short human AML1 isoform, in embryonic stem cells suppresses in vivo tumor growth and differentiation [PDF]

, 1998
Revital Ben Aziz‐Aloya, Ditsa Levanon, Heather A. Karn, Debora Kidron, Dalia Goldenberg, Joseph Lotem, Sylvie Polak-Chaklon, Yoram Groner   +7 more
openalex   +1 more source

Delivery of A Chemically Modified Noncoding RNA Domain Improves Dystrophic Myotube Function

Advanced Science, EarlyView.
CYTOR is a pro‐myogenic ncRNA in skeletal muscle. Here, chemical probing of CYTOR, coupled with functional cellular assays identifies exon 2 as an independent myogenic RNA domain. Chemical engineering of CYTOR exon 2 RNA improves pharmacologic properties, including RNA stability and cell‐autonomous immunogenicity.
Zeinabou Niasse‐Sy, Bo Zhao, Ajda Lenardič, Huyen Thuc Tran Luong, Ori Bar‐Nur, Johan Auwerx, Martin Wohlwend   +6 more
wiley   +1 more source

Introduction of specific point mutations into RNA polymerase II by gene targeting in mouse embryonic stem cells: evidence for a DNA mismatch repair mechanism.

, 1990
C M Steeg, James Ellis, A Bernstein
openalex   +1 more source

Gene conversion during vector insertion in embryonic stem cells [PDF]

, 1995
Paul Hasty, Jaime A. Rivera‐Pérez, Allan Bradley   +2 more
openalex   +1 more source