Results 91 to 100 of about 4,182 (225)

Distribution and Excretion of BisGMA in Guinea Pigs [PDF]

, 2008
Bisphenol-A-glycidyldimethacrylate (BisGMA) is used in many resin-based dental materials. It was shown in vitro that BisGMA was released into the adjacent biophase from such materials during the first days after placement.
Kunzelmann, K.H., Seiss, M., Kehe, K., Reichl, F.X., Kleinsasser, N., Hickel, R., Thomas, P., Spahl, W.   +7 more
core   +1 more source

Embryotoxicity Hazard Assessment of Methylmercury and Chromium Using Embryonic Stem Cells

, 2007
The embryonic stem cell test (EST) has been scientifically validated (2001) as an in vitro embryotoxicity test, showing a good overall test accuracy of 78%.
STUMMANN Tina, BREMER Susanne, HARENG Lars   +2 more
core   +1 more source

Protein Biomarkers for in Vitro Testing of Embryotoxicity

, 2010
There are new challenges for hazard and risk assessment in the chemical industry with regard to REACH legislation in Europe and related activities in the U.S.
Tina C. Stummann, Steemans, M., Hayess, K., Seiler, A., Horst Spielmann, Schrattenholz, A., Petra Jaeckel, Poznanovic, S., Slobodan Poznanovic, Jaeckel, P., Stegmann, W., Andrea Seiler, Woijciech Wozny, Chaturvedala Sastri, Schopf, R., Sastri, C., Zengerling, H., Martina Klemm-Manns, Klemm-Manns, M., Katrin Hayess, Gerhard Schwall, Peters, A.K., Werner Stegmann, André Schrattenholz, Rainer Schöpf, Spielmann, H., Schwall, G., Margino Steemans, Annelieke K. Peters, Groebe, K., Wozny, W., Helmut Zengerling, Karlfried Groebe, Stummann, T.C.   +33 more
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Lysosomal cysteine proteinases and their role in visceral yolk sac mediated nutrition and embryotoxicity.

, 1994
The embryotoxicity of certain chemicals has been associated with an inhibition of protein degradation in the visceral yolk sac (VYS), an extraembryonic membrane responsible for embryonic amino acid supply prior to the formation of the functional placenta.
Ambroso, Jeffrey Lee
core  

Assaying embryotoxicity in the test tube: Current limitations of the embryonic stem cell test (EST) challenging its applicability domain

, 2012
Testing for embryotoxicity in vitro is an attractive alternative to animal experimentation. The embryonic stem cell test (EST) is such a method, and it has been formally validated by the European Centre for the Validation of Alternative Methods. A number
Riebeling,C., Seiler,A.E.M., Steemans,M., Spielmann,H., Luch,A., Hayess,K., Peters,A.K.   +6 more
core   +1 more source

Impact of Nicotine Exposure on Hair Cell Toxicity and Embryotoxicity During Zebrafish Development [PDF]

, 2018
Objectives Nicotine has various adverse effects including negative impacts associated with maternal exposure. In the current study, we examined nicotine-induced damage of hair cells and embryotoxicity during zebrafish development.
Yoon Chan Rah, Soonil Koun, Sung Won Chae, Gi Jung Im, Saemi Park, June Choi, Hak Hyun Jung, Myung Hoon Yoo   +7 more
core   +1 more source

Synergistic Embryotoxicity of Polycyclic Aromatic Hydrocarbon Aryl Hydrocarbon Receptor Agonists with Cytochrome P4501A Inhibitors in -3

, 2011
Copyright information:Taken from "Synergistic Embryotoxicity of Polycyclic Aromatic Hydrocarbon Aryl Hydrocarbon Receptor Agonists with Cytochrome P4501A Inhibitors in "Environmental Health Perspectives 2004;112(17):1658-1664.Published online 18 Aug ...
Deena M. Wassenberg (71520), Richard T. Di Giulio (71521)   +1 more
core   +1 more source

Validating Preclinical Assessment of a Medicine Benefit-Risk Ratio Based on WOE and IV Models

Безопасность и риск фармакотерапии
INTRODUCTION. Mathematical models are actively used in biomedical research, including efficacy and safety prediction of medicinal products. Scientific Centre for Expert Evaluation of Medicinal Products has developed and implemented a method for ...
D. M. Ivashova, O. V. Schreder, D. V. Goryachev   +2 more
doaj   +1 more source

Polyhydroxy steroids isolated from starfish (Asterina pectinifera) and their embryotoxicity

Many marine organisms possess an essential capacity to produce secondary metabolites that exhibit toxic characteristics. A new polyhydroxy steroid, 24-methyl-5 alpha-cholestane-24(28)-ene-3 beta, 4 beta, 6 alpha, 7 alpha, 8, 15 beta, 16 beta, 26-octol-6 ...
Sun, Xueting, Lu, Zhen, Wang, Derui, Yan, Zhi, Li, Ke, Li, Xiaodong, Zhang, Ranran, Yin, Xiuli   +7 more
core   +1 more source

Synergistic Embryotoxicity of Polycyclic Aromatic Hydrocarbon Aryl Hydrocarbon Receptor Agonists with Cytochrome P4501A Inhibitors in -1

, 2011
Copyright information:Taken from "Synergistic Embryotoxicity of Polycyclic Aromatic Hydrocarbon Aryl Hydrocarbon Receptor Agonists with Cytochrome P4501A Inhibitors in "Environmental Health Perspectives 2004;112(17):1658-1664.Published online 18 Aug ...
Deena M. Wassenberg (71520), Richard T. Di Giulio (71521)   +1 more
core   +1 more source