Results 81 to 90 of about 2,310 (177)

Methylxanthines induce structural and functional alterations of the cardiac system in zebrafish embryos

BMC Pharmacology and Toxicology, 2017
Background Zebrafish embryos are emerging as a model for pharmacological and toxicological studies. We used zebrafish embryos to study the general toxicity and cardiovascular effects of eight methylxanthines: aminophylline, caffeine, diprophylline ...
Ram Manohar Basnet, Daniela Zizioli, Michela Guarienti, Dario Finazzi, Maurizio Memo   +4 more
doaj   +1 more source

Decrease of intracellular pH as possible mechanism of embryotoxicity of glycol ether alkoxyacetic acid metabolites

, 2010
Embryotoxicity of glycol ethers is caused by their alkoxyacetic acid metabolites, but the mechanism underlying the embryotoxicity of these acid metabolites is so far not known.
Verwei, M., Blaauboer, B.J., Rietjens, I.M.C.M., Louisse, J., Sandt, J.J.M. van de, Bai, Y.   +5 more
core  

The validated embryonic stem cell test to predict embryotoxicity in vitro

, 2011
In the embryonic stem cell test (EST), differentiation of mouse embryonic stem cells (mESCs) is used as a model to assess embryotoxicity in vitro. The test was successfully validated by the European Center for the Validation of Alternative Methods (ECVAM)
Andrea E M Seiler, Horst Spielmann, Seiler, A. E. M., Spielmann, H.   +3 more
core   +1 more source

Synergistic Embryotoxicity of Polycyclic Aromatic Hydrocarbon Aryl Hydrocarbon Receptor Agonists with Cytochrome P4501A Inhibitors in -3

, 2011
Copyright information:Taken from "Synergistic Embryotoxicity of Polycyclic Aromatic Hydrocarbon Aryl Hydrocarbon Receptor Agonists with Cytochrome P4501A Inhibitors in "Environmental Health Perspectives 2004;112(17):1658-1664.Published online 18 Aug ...
Deena M. Wassenberg (71520), Richard T. Di Giulio (71521)   +1 more
core   +1 more source

Assesment of sediment contamination by spermiotoxicity and embryotoxicity bioassays with sea urchins (Paracentrotus lividus) and oysters (Crassostrea gigas)

, 2001
Gametes (sperm) and fertilized eggs (embryos) of the Mediterranean sea urchin, Paracentrotus lividus, and the Japanese oyster, Crassostrea gigas, were used to investigate the toxicity of two marine sediments, one polluted by polycyclic aromatic ...
Matthias N. L. Seaman, Augagneur, S., Geffard, O., Sylvie Augagneur, His, E., Seaman, Matthias N. L., Olivier Geffard, Budzinski, H., Helene Budzinski, Edouard His   +9 more
core   +1 more source

Synergistic Embryotoxicity of Polycyclic Aromatic Hydrocarbon Aryl Hydrocarbon Receptor Agonists with Cytochrome P4501A Inhibitors in -1

, 2011
Copyright information:Taken from "Synergistic Embryotoxicity of Polycyclic Aromatic Hydrocarbon Aryl Hydrocarbon Receptor Agonists with Cytochrome P4501A Inhibitors in "Environmental Health Perspectives 2004;112(17):1658-1664.Published online 18 Aug ...
Deena M. Wassenberg (71520), Richard T. Di Giulio (71521)   +1 more
core   +1 more source

Shortening and Improving the Embryonic Stem Cell Test through the Use of Gene Biomarkers of Differentiation

Journal of Toxicology, 2011
The embryonic Stem cell Test (EST) is a validated assay for testing embryotoxicity in vitro. The total duration of this protocol is 10 days, and its main end-point is based on histological determinations.
Andrea C. Romero, Eugenio Vilanova, Miguel A. Sogorb   +2 more
doaj   +1 more source

Differential effects on angiogenesis of two antimalarial compounds, dihydroartemisinin and artemisone : implications for embryotoxicity

, 2007
Artemisinin derivatives are highly effective and well-tolerated antimalarial drugs that now form the basis of antimalarial combination therapies recommended by the World Health Organization.
Parati, Eugenio Agostino, E. A. Parati, Haynes, Richard K., R. K. Haynes, S. D'Alessandro, D. Taramelli, D'Alessandro, Sarah, Basilico, Nicoletta, Taramelli, Donatella, M. Gelati, N. Basilico, Gelati, Maurizio   +11 more
core   +1 more source

Toxicological Effects of Glufosinate-Ammonium-Containing Commercial Formulations on Biomphalaria glabrata in Aquatic Environments: A Multidimensional Study from Embryotoxicity to Histopathology

Toxics
Glufosinate-ammonium (GLA) is a broad-spectrum herbicide widely used for weed control. However, its potential toxic effects on non-target aquatic organisms, especially in freshwater ecosystems, are of growing concern.
Yuncheng Qian, Jialu Xu, Yilu Feng, Ruiqi Weng, Keda Chen, Hezheng Zheng, Xianwei Li, Qingzhi Zhao, Xiaofen Zhang, Hongyu Li   +9 more
doaj   +1 more source

Multiparameter analysis of Diuron and its metabolites (DCA and DCPMU) in different stages of zebrafish (Danio rerio) development

Frontiers in Water
IntroductionDiuron (3-(3,4-dichlorophenyl)-1,1-dimethylurea) is a prominent herbicide in Brazilian agriculture, particularly in sugarcane farming. This herbicide persists in the environment and is transformed into potentially toxic metabolites, such as 3,
Paloma Vitória Lima Peixoto, Bianca Camargo Penteado Sales, Luiza Aggio, Cristina Viriato, Lilian Cristina Pereira   +4 more
doaj   +1 more source