Results 71 to 80 of about 4,182 (225)

Advancing Maternal Health with Long‐Acting Therapeutics: Priorities, Efficacy and Safety Considerations, and Emerging Technologies

Clinical Pharmacology &Therapeutics, Volume 119, Issue 5, Page 1179-1194, May 2026.
Maternal health remains a critical global concern, particularly in underserved populations and in low‐ and middle‐income countries where access to safe and effective therapeutics is limited. Despite the use of medications by most women during pregnancy, the exclusion of pregnant and lactating women from clinical trials has resulted in significant data ...
Rachel K. Scott, Sharon Nachman, Ethel D. Weld, Rachel Daley, Shakir Atoyebi, Robert Bies, Catriona Waitt, Adeniyi Olagunju   +7 more
wiley   +1 more source

Toxic Effects of Polystyrene Microplastics and Sulfamethoxazole on Early Neurodevelopment in Embryo–Larval Zebrafish (Danio rerio)

Toxics
Microplastics (MPs) and antibiotics have emerged as contaminants of global concern, posing potential threats to ecosystem security and organismal health.
Fantao Meng, Shibo Ma, Yajun Wang, Chunmei Wang, Ruoming Li, Jiting Wang   +5 more
doaj   +1 more source

Essential and toxic elements intake from botanical extracts: a probabilistic risk–benefit evaluation within the Italian dietary context

Journal of the Science of Food and Agriculture, Volume 106, Issue 7, Page 4060-4072, May 2026.
Abstract BACKGROUND Botanical extracts are widely consumed for their claimed health benefits, yet their safety profile with respect to chronic consumption remains poorly characterized. Understanding the potential health risks associated with their inorganic content is a crucial issue for ensuring safe use, along with a characterization of the ...
Giovanni Tommaso Lanza, Maria Olga Varrà, Lenka Husáková, Martina Piroutková, Jan Patočka, Emanuela Zanardi   +5 more
wiley   +1 more source

Embryotoxicity Assay of Aflatoxin Produced by Aspergillus Parasiticus NRRL 2999

, 2000
1. The embryotoxicity of mixed aflatoxins (AF) and aflatoxin B-1 (AFB(1)) were evaluated by a modified chick embryotoxicity screening test (CHEST). Adverse effects on the early embryonic development of thymus and bursa of Fabricius were also investigated
Boydak, M., Demet, O., Dönmez, H. H., Nizamlıoğlu, F., Oğuz, H., Sur, E., Çelik, İ.   +6 more
core   +1 more source

Toxic Effects of BPAF on Marine Medaka (Oryzias melastigma) During Embryo–Larval Stages

Toxics
BPAF (Bisphenol AF), one of the primary substitutes for BPA (Bisphenol A), is widely used in the production of plastics, optical fibers, and other materials.
Jiahao Gao, Tianyang Zhou, Zuchun Chen, Ning Zhang, Yusong Guo, Zhongduo Wang, Wenjun Shi, Zhongdian Dong   +7 more
doaj   +1 more source

PSMA‐Targeting Macrophage Membrane‐Coated Nanoparticles for Precision Diagnosis and Combination Therapy of Prostate Cancer

Exploration, Volume 6, Issue 2, April 2026.
Advanced prostate cancer is highly invasive and prone to rapid metastasis, creating an urgent need for novel therapeutic strategies. We developed a PSMA‐targeting macrophage membrane‐coated nanomedicine (P‐MMCNPs@DM1). Leveraging the immune‐evasive and active‐targeting properties of macrophage membrane coating, P‐MMCNPs@DM1 effectively managed both ...
Keying Zhang, Bo Gao, Jingwei Wang, Yu Li, Chao Xu, Fa Yang, Shaojie Liu, Hongji Li, Chao Zhang, Xiangliang Meng, Zhaokun Shi, Rui Zhang, Ruili Zhang, Zhongliang Wang, Weihong Wen, Qiang Zhang, Yuankang Zou, Donghui Han, Huijie Bian, Weijun Qin   +19 more
wiley   +1 more source

Pesticide Contamination in the Hair of Children From Colonia San Juan, a Rural Community in Paraguay

Drug Testing and Analysis, Volume 18, Issue 3, Page 354-369, March 2026.
Hair analysis in children from a rural community in Paraguay reveals exposure to organophosphates, pyrethroids, neonicotinoids, fungicides, herbicides, and endocrine disruptors, highlighting the urgent need for stricter environmental protections and preventive health measures. ABSTRACT Chronic exposure to pesticides can cause carcinogenic, reproductive,
Stela Benitez Leite, Alba Iglesias‐Gonzalez, Mirta Noemí Mesquita, María Luisa Macchi, Robin Mesnage, Brice M. R. Appenzeller   +5 more
wiley   +1 more source

Embryotoxicity test of thyroxine on chick embryo.

, 2013
Thyroxine is the main thyroid gland's hormone. The state, when the thyroid gland does not produce enough of it into the bloodstream is called hypothyroidism.
Petrušková, Michaela
core  

Embryotoxicity Caused by DON-Induced Oxidative Stress Mediated by Nrf2/HO-1 Pathway

, 2017
Deoxynivalenol (DON) belongs to the type B group of trichothecenes family, which is composed of sesquiterpenoid metabolites produced by Fusarium and other fungi in grain.
Hanyin Wang, Liangkai Chen, Wei Yang, Andreas Nüssler, Miao Yu, Ping Yao, Yadong Song, Liegang Liu, Zhao Peng, Di Wang, Hong Yan, Andreas K. Nüssler   +11 more
core   +1 more source

Methylxanthines induce structural and functional alterations of the cardiac system in zebrafish embryos

BMC Pharmacology and Toxicology, 2017
Background Zebrafish embryos are emerging as a model for pharmacological and toxicological studies. We used zebrafish embryos to study the general toxicity and cardiovascular effects of eight methylxanthines: aminophylline, caffeine, diprophylline ...
Ram Manohar Basnet, Daniela Zizioli, Michela Guarienti, Dario Finazzi, Maurizio Memo   +4 more
doaj   +1 more source