Results 1 to 10 of about 6,268 (192)

Emerin expression stratification across breast cancer subtypes [PDF]

Cancer Treatment and Research Communications
Nuclear dysmorphism is a critical indicator of tumor aggressiveness, influencing cancer cell invasion and metastasis. Emerin, an integral nuclear envelope protein involved in nuclear architecture, is important for maintaining nuclear integrity.
Thaysa Ghiarone, Emily Hansen, James M. Holaska   +2 more
doaj   +3 more sources

Emerin deficiency drives MCF7 cells to an invasive phenotype [PDF]

Scientific Reports
During metastasis, cancer cells traverse the vasculature by squeezing through very small gaps in the endothelium. Thus, nuclei in metastatic cancer cells must become more malleable to move through these gaps.
Emily Hansen, Christal Rolling, Matthew Wang, James M. Holaska   +3 more
doaj   +6 more sources

Probing the Environment of Emerin by Enhanced Ascorbate Peroxidase 2 (APEX2)-Mediated Proximity Labeling [PDF]

Cells, 2020
Emerin is one of the best characterized proteins of the inner nuclear membrane, but can also occur at the level of the endoplasmic reticulum. We now use enhanced ascorbate peroxidase 2 (APEX2) to probe the environment of emerin.
Marret Müller, Christina James, Christof Lenz, Henning Urlaub, Ralph H. Kehlenbach   +4 more
doaj   +3 more sources

Activity-dependent synthesis of Emerin gates neuronal plasticity by regulating proteostasis [PDF]

Cell Reports
Summary: Neurons dynamically regulate their proteome in response to sensory input, a key process underlying experience-dependent plasticity. We characterized the visual experience-dependent nascent proteome in mice within a brief, defined time window ...
Yi Xie, Ruoxi Wang, Daniel B. McClatchy, Yuanhui Ma, Jolene Diedrich, Manuel Sanchez-Alavez, Michael Petrascheck, John R. Yates, III, Hollis T. Cline   +8 more
doaj   +2 more sources

ERM proteins support perinuclear actin rim formation [PDF]

Frontiers in Cell and Developmental Biology
The interaction of actin filaments with the nuclear envelope is essential for diverse cellular processes, including cell migration, nuclear positioning, and transcriptional control.
Yuval Hadad, Andrea Fracchia, Dagmawit Babele, Amit Ben Shushan, Gabi Gerlitz   +4 more
doaj   +2 more sources

Profibrotic Molecules Are Reduced in CRISPR-Edited Emery–Dreifuss Muscular Dystrophy Fibroblasts [PDF]

Cells
Emery–Dreifuss muscular dystrophy (EDMD) is caused by mutations in EMD, LMNA, SYNE1, SYNE2, and other related genes. The disease is characterized by joint contractures, muscle weakening and wasting, and heart conduction defects associated with dilated ...
Eleonora Cattin, Elisa Schena, Elisabetta Mattioli, Stefania Marcuzzo, Silvia Bonanno, Paola Cavalcante, Federico Corradi, Daniela Benati, Giorgia Farinazzo, Marco Cattaneo, Veronica De Sanctis, Roberto Bertorelli, Lorenzo Maggi, Melania Giannotta, Antonella Pini, Gaetano Vattemi, Denise Cassandrini, Marco Cavallo, Cristina Manferdini, Gina Lisignoli, Beatrice Fontana, Ilaria Pace, Claudio Bruno, Roberta Roncarati, Chiara Fiorillo, Manuela Ferracin, Eric C. Schirmer, Alessandra Recchia, Giovanna Lattanzi   +28 more
doaj   +2 more sources

C-terminal tagging, transmembrane domain hydrophobicity, and an ER retention motif influence the secretory trafficking of the inner nuclear membrane protein emerin [PDF]

eLife
The inner nuclear membrane (INM), a subdomain of the endoplasmic reticulum (ER), sequesters hundreds of transmembrane proteins within the nucleus. We previously found that one INM protein, emerin, can evade the INM by secretory transport to the lysosome,
Jessica Mella, Regan F Volk, Balyn W Zaro, Abigail Buchwalter   +3 more
doaj   +2 more sources

Emerin mislocalization during chromatin bridge resolution can drive prostate cancer cell invasiveness in a collagen-rich microenvironment [PDF]

Experimental and Molecular Medicine
Micronuclei (MN) can form through many mechanisms, including the breakage of aberrant cytokinetic chromatin bridges. The frequent observation of MN in tumors suggests that they might not merely be passive elements but could instead play active roles in ...
Marta Popęda, Kamil Kowalski, Tomasz Wenta, Galina V. Beznoussenko, Michał Rychłowski, Alexander Mironov, Zeno Lavagnino, Sara Barozzi, Julia Richert, Rebecca Bertolio, Kamil Myszczyński, Jolanta Szade, Michał Bieńkowski, Kevin Miszewski, Marcin Matuszewski, Anna J. Żaczek, Luca Braga, Giannino Del Sal, Natalia Bednarz-Knoll, Paolo Maiuri, Paulina Nastały   +20 more
doaj   +2 more sources

Role of Emerin in regulating fibroblast differentiation and migration at the substrate of stiffness coupled topology [PDF]

Acta Biochimica et Biophysica Sinica
In hypertrophic scars, the differentiation and migration of fibroblasts are influenced by the extracellular matrix microenvironment, which includes factors such as stiffness, restraint, and tensile force.
Yang Tiantian, Wang Li, Ma Haiyang, Li Kailun, Wang Yajing, Tang Wenjie, Wang Zichen, An Meiwen, Gao Xiang, Xu Ludan, Guo Yunyun, Guo Jiqiang, Liu Yong, Wang Hugen, Liu Yang, Zhang Quanyou   +15 more
doaj   +2 more sources

Emerin interacts with histone methyltransferases to regulate repressive chromatin at the nuclear periphery

Frontiers in Cell and Developmental Biology, 2022
X-Linked Emery-Dreifuss muscular dystrophy is caused by mutations in the gene encoding emerin. Emerin is an inner nuclear membrane protein important for repressive chromatin organization at the nuclear periphery.
Nicholas Marano, James M. Holaska
doaj   +1 more source