Results 11 to 20 of about 6,268 (192)
Emerin increase in regenerating muscle fibers
European Journal of Histochemistry, 2009 The fate of emerin during skeletal muscle regeneration was investigated in an animal model by means of crush injury. Immunofluorescence, immunoblotting and mRNA analysis demonstrated that emerin level is increased in regenerating rat muscle fibers with ...
S Squarzoni +5 more
doaj +7 more sources
Emerin Phosphorylation during the Early Phase of the Oxidative Stress Response Influences Emerin–BAF Interaction and BAF Nuclear Localization [PDF]
Cells, 2020 Reactive Oxygen Species (ROS) are reactive molecules required for the maintenance of physiological functions. Oxidative stress arises when ROS production exceeds the cellular ability to eliminate such molecules.
Vittoria Cenni +5 more
doaj +4 more sources
Mechanical Stress Triggers Premature Senescence in Cardiac Fibroblasts. [PDF]
Adv Sci (Weinh)Cellular senescence contributes to disease burden in cardiovascular disease (CVD) and aging, highlighting the need to understand its induction. In primary cardiac fibroblasts, reduced strain and increased frequency, mimicking CVD, elicit a distinct senescent phenotype compared to oxidative stress.
Schneider SE +5 more
europepmc +2 more sources
Temporal Stretch-Induced Nuclear Mechanosensing Coordinates Early Chromatin Accessibility and Genome Protection. [PDF]
Adv Sci (Weinh)Cyclic stretching of fibroblasts triggers coordinated nuclear mechanosensing events, including calcium ion release, perinuclear actin assembly, emerin translocation, and H3K9me3 loss, increasing chromatin accessibility for specific genes related to mechanotransduction and repair.
Shim HW +10 more
europepmc +2 more sources
Emerin in health and disease [PDF]
Seminars in Cell & Developmental Biology, 2014 Emery-Dreifuss muscular dystrophy (EDMD) is caused by mutations in the genes encoding emerin, lamins A and C and FHL1. Additional EDMD-like syndromes are caused by mutations in nesprins and LUMA. This review will specifically focus on emerin function and the current thinking for how loss or mutations in emerin cause EDMD.
Adam J, Koch, James M, Holaska
openaire +2 more sources
HSV-1 US3: A Master Mimic Hijacking Host Kinase Networks for Viral Dominance. [PDF]
J Med VirolABSTRACT Herpes simplex virus type 1 (HSV‐1) encodes the serine/threonine kinase US3, a central regulator of host–virus interactions that promotes viral replication, latency, and reactivation. Despite limited sequence homology to cellular kinases such as Akt or PKA, US3 phosphorylates diverse substrates to manipulate multiple pathways.
Hossain I +5 more
europepmc +2 more sources
The Role of Emerin in Cancer Progression and Metastasis [PDF]
International Journal of Molecular Sciences, 2021 It is commonly recognized in the field that cancer cells exhibit changes in the size and shape of their nuclei. These features often serve as important biomarkers in the diagnosis and prognosis of cancer patients. Nuclear size can significantly impact cell migration due to its incredibly large size.
Alexandra G. Liddane, James M. Holaska
openaire +2 more sources
Loss of emerin alters myogenic signaling and miRNA expression in mouse myogenic progenitors. [PDF]
PLoS ONE, 2012 Emerin is an integral membrane protein of the inner nuclear membrane. Mutations in emerin cause X-linked Emery-Dreifuss muscular dystrophy (EDMD), a disease characterized by skeletal muscle wasting and dilated cardiomyopathy.
Adam J Koch, James M Holaska
doaj +1 more source
Open Biology, 2023 Mitotic exit requires the dephosphorylation of many proteins whose phosphorylation was needed for mitosis. Protein phosphatase 2A with its B55 regulatory subunit (PP2A-B55) promotes this transition.
Virginie Emond-Fraser +8 more
doaj +1 more source
The nuclear envelope LEM-domain protein emerin [PDF]
Nucleus, 2013 Emerin, a conserved LEM-domain protein, is among the few nuclear membrane proteins for which extensive basic knowledge--biochemistry, partners, functions, localizations, posttranslational regulation, roles in development and links to human disease--is available.
Berk, Jason M +2 more
openaire +2 more sources