Results 61 to 70 of about 285,203 (291)

Structural instability impairs function of the UDP‐xylose synthase 1 Ile181Asn variant associated with short‐stature genetic syndrome in humans

open access: yesFEBS Letters, EarlyView.
The Ile181Asn variant of human UDP‐xylose synthase (hUXS1), associated with a short‐stature genetic syndrome, has previously been reported as inactive. Our findings demonstrate that Ile181Asn‐hUXS1 retains catalytic activity similar to the wild‐type but exhibits reduced stability, a looser oligomeric state, and an increased tendency to precipitate ...
Tuo Li   +2 more
wiley   +1 more source

Inhibiting stearoyl‐CoA desaturase suppresses bone metastatic prostate cancer by modulating cellular stress, mTOR signaling, and DNA damage response

open access: yesFEBS Letters, EarlyView.
Bone metastasis in prostate cancer (PCa) patients is a clinical hurdle due to the poor understanding of the supportive bone microenvironment. Here, we identify stearoyl‐CoA desaturase (SCD) as a tumor‐promoting enzyme and potential therapeutic target in bone metastatic PCa.
Alexis Wilson   +7 more
wiley   +1 more source

Research Report on Phase 5 Of Cornell University/Gevity Institute Study: Human Resource Management Practices and Firm Performance In Small Businesses: A Look At Differences Across Industries [PDF]

open access: yes, 2007
In this study, we look at the effects of three HR practice strategies on firm performance and examine potential differences in effects across industries.
Collins, Christopher J
core   +1 more source

The (Glg)ABCs of cyanobacteria: modelling of glycogen synthesis and functional divergence of glycogen synthases in Synechocystis sp. PCC 6803

open access: yesFEBS Letters, EarlyView.
We reconstituted Synechocystis glycogen synthesis in vitro from purified enzymes and showed that two GlgA isoenzymes produce glycogen with different architectures: GlgA1 yields denser, highly branched glycogen, whereas GlgA2 synthesizes longer, less‐branched chains.
Kenric Lee   +3 more
wiley   +1 more source

Retention Strategies for Technical Talents in the Technological Sector

open access: yesJournal of Human Resource Management
Purpose – Despite the growing recognition of human capital as a key driver of organizational success, many technological companies in Lagos State face persistent challenges in retaining skilled employees.
Abdulmaleek Olawale ABDULAZEEZ   +2 more
doaj   +1 more source

Identify Critical Factors to Turn Workforce Satisfaction into Bottom-Line Results [PDF]

open access: yes, 2010
KEY FINDINGS · While practitioners and researchers assume that higher employee satisfaction equals higher sales and profits, analysis shows that there is no direct link between the two.
Center for Advanced Human Resource Studies
core   +1 more source

Structural biology of ferritin nanocages

open access: yesFEBS Letters, EarlyView.
Ferritin is a conserved iron‐storage protein that sequesters iron as a ferric mineral core within a nanocage, protecting cells from oxidative damage and maintaining iron homeostasis. This review discusses ferritin biology, structure, and function, and highlights recent cryo‐EM studies revealing mechanisms of ferritinophagy, cellular iron uptake, and ...
Eloise Mastrangelo, Flavio Di Pisa
wiley   +1 more source

ANALYSIS ON EQUITY SHARE BEING OFFERED TO ELIGIBLE EMPLOYEES FOR EMPLOYEE RETENTION IN LARGE CAP STOCKS

open access: yesICTACT Journal on Management Studies
Equity shares are increasingly utilized by companies to retain talent and align employee interests with organizational goals. Large-cap stocks, due to their stability and growth potential, offer a unique context for evaluating this retention strategy ...
Anil Kumar Yadav
doaj   +1 more source

The Search for Satisfaction: Report from the UMDLaw Alumni Career Path Survey [PDF]

open access: yes, 2010
In 2007, UMDLaw began exploring the decisions graduates make in shaping their careers and their satisfaction with the results of those decisions.
LaMaster, Teresa
core   +1 more source

Structural insights into an engineered feruloyl esterase with improved MHET degrading properties

open access: yesFEBS Letters, EarlyView.
A feruloyl esterase was engineered to mimic key features of MHETase, enhancing the degradation of PET oligomers. Structural and computational analysis reveal how a point mutation stabilizes the active site and reshapes the binding cleft, expading substrate scope.
Panagiota Karampa   +5 more
wiley   +1 more source

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