Results 71 to 80 of about 3,779 (279)
Molecular Oncology, EarlyView.We have established a humanized orthotopic patient‐derived xenograft (Hu‐oPDX) mouse model of high‐grade serous ovarian cancer (HGSOC) that recapitulates human tumor–immune interactions. Using combined anti‐PD‐L1/anti‐CD73 immunotherapy, we demonstrate the model's improved biological relevance and enhanced translational value for preclinical ...
Luka Tandaric +10 more
wiley +1 more source
İstanbul Gelişim Üniversitesi Sosyal Bilimler DergisiAim: This study investigates how intrinsic motivation among the creative class moderates the relationship between social undermining and organizational silence.
Ferda Üstün, Şeyma Ersolak
doaj +1 more source
Molecular Oncology, EarlyView.We analyze cisplatin–DNA adducts (CDAs) and double‐strand breaks (DSBs) in a cell‐cycle‐dependent manner. We find that CDAs form similarly across all cell cycle phases. DSBs arise only in S‐phase. CDAs might not directly impair DSB repair, but S‐phase DSB lesions evolve in the presence of CDAs and disrupt repair in G2, also causing radiosensitization ...
Ye Qiu +10 more
wiley +1 more source
Molecular Oncology, EarlyView.Intratumour heterogeneity complicates precision management of advanced endometrial cancer. Circulating tumor DNA (ctDNA) offers a minimally invasive strategy to capture tumor evolution and therapeutic resistance. Here, we compare tumor‐agnostic NGS with tumor‐informed ddPCR, outlining their relative sensitivity, concordance, and clinical implications ...
Carlos Casas‐Arozamena +15 more
wiley +1 more source
, 2020 Employee silence is a silent killer of organizations, stripping them of lost revenue, productivity, and divergent thought. If organizations wish to reduce employee silence behaviors, they need to understand the factors in their organizational culture and
Flanagan-Benedict, Geneva
core
Molecular Oncology, EarlyView.Circulating tumor cells (CTCs) and plasma cell‐free DNA (cfDNA) were analyzed to detect ESR1 mutations and methylation in patients with advanced breast cancer. CTC‐derived DNA showed higher sensitivity for mutation detection and revealed complementary genetic and epigenetic alterations, highlighting the added value of CTC analysis for understanding ...
Dimitra Stergiopoulou +12 more
wiley +1 more source
ORGANIZATIONAL SILENCE IN WHITE-COLLAR WORKERS: A RESEARCH ON BANK BRANCH EMPLOYEES
Sakarya Üniversitesi İktisat Dergisi, 2017 The purpose of this researchis to examine the factors that create the organizational silence climate overoccupational silence, and the effects of employee silence behavior on jobsatisfaction, organizational commitment and burnout.For the research ...
Bülent Turan, Gürkan Haşit
doaj
Interpreting the effects of DNA polymerase variants at the structural level
Molecular Oncology, EarlyView.Using MAVISp and molecular dynamics simulations, we analyzed over 60 000 missense variants in POLE and POLD1 from ClinVar, COSMIC, cBioPortal, and saturation mutagenesis. Identified mechanistic indicators, including stability, binding, and long‐range, enable structural interpretation, providing ACMG‐like evidence for possible reclassification of VUS ...
Matteo Arnaudi +7 more
wiley +1 more source
Introducing the employee into employee silence: a reconceptualisation of employee silence from the perspective of those with mental health issues within the workplace [PDF]
, 2017 In recent years, employee silence has emerged as an important construct and field of study. This thesis contributes to knowledge about the ontological foundations of silence, focusing on who is remaining silent and what they are remaining silent about ...
Morgan, Kate Elizabeth
core
Employee silence motives: Investigation of dimensionality and development of measures
, 2012 In four studies, I examine the motives for employee silence. In Study 1, I examine open-ended survey responses to determine the nature and scope of silence motives. Study 2 develops measures of these motives and explores their factor structure.
Brinsfield, Chad T
core +1 more source