Results 91 to 100 of about 3,779 (279)

Loss of proton‐sensing TDAG8 increases tumor progression in mouse models of colon cancer

Molecular Oncology, EarlyView.
Loss of the pH‐sensing receptor TDAG8 accelerates colorectal cancer progression in mice. Animals lacking TDAG8 expression had increased tumor growth, DNA damage, and recruitment of tumor‐associated immune cells, including macrophages, neutrophils, and monocytes.
Ermanno Malagola, Yasmine Illi, Anna Bircher, Marijn Wilmink, Rachele F. Malagutti, Solenn Ottié, Cordelia Schuler, Pedro A. Ruiz, Cheryl de Vallière, Klaus Seuwen, Gerhard Rogler, Martin Hausmann   +11 more
wiley   +1 more source

Silêncio organizacional: introdução e crítica

Cadernos EBAPE.BR
Resumo: Com as mudanças ocorridas a partir dos anos 1970, as organizações passaram a requerer maior participação de seus trabalhadores nos processos de trabalho. A comunicação franca e aberta torna-se vital nesse cenário.
Marcos Júnior de Moura-Paula, Deise Luiza da Silva Ferraz   +1 more
doaj   +1 more source

Epigenetic heterogeneity and plasticity in therapy‐induced tumor states through single‐cell multi‐omics

Molecular Oncology, EarlyView.
Single‐cell multi‐omics reveals epigenetic heterogeneity across therapy‐adaptive tumor states, including quiescent/dormant, drug‐tolerant persister, and EMT‐like phenotypes. By linking regulatory features with state‐associated biomarkers, these approaches inform biomarker‐guided therapeutic strategies for evolving tumors.
Hee Jung Kim, Hwiyeong Lee, Jin Hong, Daechan Park   +3 more
wiley   +1 more source

Effect of Toxic Leadership on Workplace Bullying: A Mediation and Moderation Analysis

Journal of Management and Research
This study investigates the impact of toxic leadership on workplace bullying across multiple sectors in Gujranwala, Pakistan, emphasizing the mediating effects of employee silence and psychological well-being, as well as the moderating effect of ...
Zain Ashfaq, Anam Ashraf, Jamshaid Ahmad
doaj   +1 more source

Linking ethical leadership to employee voice and employee silence: investigations of causality and underlying mechanisms

, 2019
Encouraging employees to ‘voice’ their opinions and ideas is an essential way for organizations to survive and develop in a dynamic and competitive business world.
Xiang Li (114679)
core   +1 more source

PAK1 activation drives divergent resistance mechanisms to aromatase inhibition and tamoxifen in a luminal: A breast cancer model

Molecular Oncology, EarlyView.
Breast cancer remains a major cause of cancer death in women, frequently developing endocrine therapy resistance. This study demonstrates that upregulated p21‐activated kinase 1 (PAK1) activity drives resistance to tamoxifen and long‐term estrogen deprivation in ER+ breast cancer models.
Luisa Schwarzmüller, Janina Müller, Efstathios‐Iason Vlachavas, Lukas Beumers, Lena Fleischhacker, Sara Burmester, Angelika Wörner, Sabine Karolus, Dominic Helm, Cindy Körner, Stefan Wiemann   +10 more
wiley   +1 more source

Inhibition of cyclin‐dependent kinases 12/13 using CT7439 as a treatment for colorectal cancer with CDK12 upregulation

Molecular Oncology, EarlyView.
The proposed mechanism of action for the CDK12/13 inhibitor and cyclin K degrader, CT7439. CDK12/13 inhibition interrupts transcription elongation, leading to increased DNA damage that results in cell death. This agent is a potentially novel treatment option for patients with colorectal cancer. Created in BioRender. Cyclin‐dependent kinase (CDK) 12 and
Wylie K. Watlington, Divya L. Dayanidhi, Mohammad Zokaasadi, John B. Mantyh, Pelumi D. Olawuni, Gabrielle Rupprecht, Jeremy M. Force, Shannon McCall, Ashwani K. Bahl, David S. Hsu, Jason A. Somarelli   +10 more
wiley   +1 more source

Organizational Silence Behaviors Role on Employee Effectiveness

, 2020
The debate on the role organisational silence behaviours play in employee effectiveness have remained unabated. More so, the education sector in Nigeria is facing challenges due to inadequate experienced talents to handle certain professional issues ...
M. I., FRANCIS-ODII,, O. U., ASIKHIA,, O., ODUYOYE,   +2 more
core  

In vitro and in silico modelling of ROS1‐positive non‐small cell lung cancer reveals fusion‐dependent tyrosine kinase inhibitor responses

Molecular Oncology, EarlyView.
Drug resistance limits treatment success in a subset of lung cancers driven by ROS1 gene alterations. Using patient‐derived cells and computer simulations, we studied three key mutations and how they affect five targeted drugs. The mutations reduced drug effectiveness in different ways by altering protein structure and behavior.
Farhan Ul Haq, Marc Terrones, Felicia Rodrigues Fortes, Anne Schepers, Alessia Denis, Christophe Deben, Ken Op de Beeck, Guy Van Camp, Geert Vandeweyer   +8 more
wiley   +1 more source

The effect of age discrimination on employee silence: The role of age similarity with familiar individuals

Acta Psychologica
This study investigates whether one person's experience of perceived discrimination at work can lead to someone they know exhibiting ineffectual silence in their own job. Data were collected using Study Response, an online panel, from focal employees and
María del Carmen Triana, Rawia Ahmed, M. Fernanda García   +2 more
doaj   +1 more source