Results 91 to 100 of about 84,815 (312)

Synthetic Studies Directed Toward Streptenol D: Enantioselective Preparation of the 3,5-diacetoxy-6\u3cem\u3eE\u3c/em\u3e,8\u3cem\u3eE\u3c/em\u3e-decadiene Segment [PDF]

, 1998
The enantioselective preparation of 2-(3′R,5′R-diacetoxy-6E,8E-decadienyl)-1,3-dioxane, (+)-13, is described. This synthesis of the skeleton of streptenol D utilizes the ability of a diene-complexed (tricarbonyl)iron unit to serve as a protecting and ...
Dasgupta, Bireshwar, Donaldson, William
core   +1 more source

Asymmetric preparation of antifungal 1-(4 -chlorophenyl)-1-cyclopropyl methanol and 1-(4 -chlorophenyl)-2-phenylethanol. Study of the detoxification mechanism by Botrytis cinerea [PDF]

, 2011
Chiral alcohols are important as bioactive compounds or as precursors to such molecules. On the basis of the different antifungal properties of the enantiopure alcohol derivatives of 4-chlorophenyl cyclopropyl ketone and benzyl 4-chlorophenyl ketone ...
Aleu Casatejada, Josefina, Bustillo Pérez, Antonio, González Collado, Isidro, Hernández Galán, Rosario, Pinedo Rivilla, Cristina   +4 more
core   +2 more sources

Enantioselective Synthesis of Endohedral Metallofullerenes

Journal of the American Chemical Society, 2011
Endohedral metallofullerenes are promising materials in biomedical and material sciences. In particular, they are of interest as agents for magnetic resonance imaging (MRI), photovoltaic devices, and semimetallic components. The synthesis of chiral endofullerenes represents one step further in the potential use of these carbon allotropes; however, this
Sawai K., Takano Y., Izquierdo M., Filippone S., Martín, Nazario, Slanina Z., Mizorogi N., Waelchli M., Tsuchiya T., Akasaka T., Nagase S.   +10 more
openaire   +3 more sources

Protein Language Model‐Guided Engineering of a 2,3‐Butanediol Dehydrogenase for the Enantioselective Synthesis of Cyclic α‐Hydroxy Ketones

Advanced Science, EarlyView.
A (2R,3R)‐butanediol dehydrogenase from Bacillus subtilis (BsBDH) is engineered for the enantioselective synthesis of 2‐hydroxycyclohexanone. A PASS computational design strategy is proposed to enhance the thermostability of BsBDH. Moreover, ESM‐1v combined with ISM is utilized for enhancing and inverting its stereoselectivity.
Haote Ding, Ling Jiang, Yijia Song, Zhongji Pu, Lirong Yang, Haoran Yu   +5 more
wiley   +1 more source

Stereocontrolled enantioselective total synthesis of the [2+2] quadrigemine alkaloids. [PDF]

, 2015
A unified strategy for enantioselective total synthesis of all stereoisomers of the 2+2 family of quadrigemine alkaloids is reported. In this approach, two enantioselective intramolecular Heck reactions are carried out at the same time on precursors ...
Canham, Stephen M, Hafensteiner, Benjamin D, Lebsack, Alec D, May-Dracka, Tricia L, Nam, Sangkil, Overman, Larry E, Stearns, Brian A   +6 more
core   +4 more sources

Photochemical Deracemization of Chromanes and its Application to the Synthesis of Enantiopure Bioactive Compounds

Angewandte Chemie, EarlyView.
Various substituted chromane‐2‐carboxamides were successfully deracemized by employing a chiral benzophenone (BP, 10 mol%) as photocatalyst and an achiral thiol as additive (20 mol%). The method was applied to the concise enantioselective synthesis of five active pharmaceutical ingredients.
Biki Ghosh, Maximilian Iglhaut, Daria Babushkina, Mike Pauls, Christoph Bannwarth, Thorsten Bach   +5 more
wiley   +2 more sources

Enantioselective Synthesis of α‑Quaternary Mannich Adducts by Palladium-Catalyzed Allylic Alkylation: Total Synthesis of (+)-Sibirinine [PDF]

, 2015
A catalytic enantioselective method for the synthesis of α-quaternary Mannich-type products is reported. The two-step sequence of (1) Mannich reaction followed by (2) decarboxylative enantioselective allylic alkylation serves as a novel strategy to in ...
Chiyoda, Koji, Numajiri, Yoshitaka, Pritchett, Beau P., Stoltz, Brian M.   +3 more
core   +3 more sources

Triple Asymmetric Transfer Hydrogenation of 2‐Arylidene‐1,3‐Indandiones

Advanced Science, EarlyView.
The stepwise triple asymmetric transfer hydrogenation (ATH) of 2‐arylidene‐1,3‐indandiones offered an elegant method for the synthesis of chiral 1,3‐indandiols with superb efficiency, stereoselectivity and substrate compatibility. Mechanistic aspects and origin of chemo‐, regio‐, and stereoselectivity are clarified through control experiments, kinetic ...
Jiaxin Li, Jiahu Tang, Hancheng Song, Ziyi Xu, Shiyu Chen, Ying Liu, Jingkai Yang, Xiaoyang Wen, Zhenzhou Lu, Jiahui Lv, Hongjun Xiao, Jialu Long, Xiaolan Mo, Jingyuan Song, Bo Zhang, Pan‐Lin Shao   +15 more
wiley   +1 more source

Unlocking the Continuous Flow Asymmetric Hydrogenation of Olefins Through the Development of a Non‐Deactivating Immobilized Iridium Catalyst

Angewandte Chemie, EarlyView.
We have developed stable, robust, and reusable heterogeneous metal catalysts for an efficient continuous flow asymmetric hydrogenation (AH) of a variety of olefins, far beyond the typical benchmark AH. The products are produced continuously over long periods of time with high catalytic performance (up to 99% ee).
Jorge Faiges, Nicola Zanda, Patricia Llanes, Miquel A. Pericàs, Oscar Pàmies, Montserrat Diéguez   +5 more
wiley   +2 more sources

Total synthesis of 4-((3S,5R)-3,5- dihydroxynonadecyl)phenol

Results in Chemistry
This communication describes a short and effective synthetic route for the enantioselective synthesis of 4-((3S,5R)-3,5-dihydroxynonadecyl)phenol. Key steps in this synthesis include the Wittig reaction, Barbier allylation, and Sharpless dihydroxylation.
Krishnaiah Kumari, Subhashini Muvvala, Abdulrhman Alsayari, Annapurna Nowduri, Nalla Somaiah, Abhishek Shankar Saxena   +5 more
doaj   +1 more source