Results 91 to 100 of about 83,738 (273)

Dearomative Higher‐Order Cycloaddition for the Construction of Dihydropyrimidin‐4(1H)‐One Scaffold Employing N‐Heterocyclic Carbene Catalysis

Advanced Synthesis &Catalysis, EarlyView.
The study presents dearomative higher‐order cycloaddition as an effective strategy for constructing the biologically important dihydropyrimidin‐4(1H)‐one core. The method employs indole‐7‐carbaldehydes as precursors of higherenes, which, under N‐heterocyclic carbene (NHC) catalysis, generate NHC‐bound aza‐o‐quinodimethanes.
Adam Cieśliński, Artur Przydacz, Anna Skrzyńska, Łukasz Albrecht   +3 more
wiley   +1 more source

Asymmetric synthesis of chiral heterobenzylic amines via visible-light-induced enantioselective C(sp3)-H alkylation

Green Synthesis and Catalysis
The chiral heterobenzylic amines, such as α-alkyl substituted chiral oxadiazole methylamine skeletons are widely present in pesticides and pharmaceuticals, due to their unique biological activities.
Yumei Huo, Beibei Chen, Xiaoyu Ren, Chao Wang, Rupeng Qi, Zhaoqing Xu   +5 more
doaj   +1 more source

P‐Stereogenic Phosphines via Mn(I)‐Catalyzed Asymmetric Hydrophosphination of Vinyl Sulfones: A Case of Solvent‐Induced Stereoinversion

Advanced Synthesis &Catalysis, EarlyView.
A new strategy for synthesis of P‐chiral phosphines via manganese‐catalyzed enantioselective hydrophosphination was established. The solvent like iPrOH was found to be able to tune the enantioselectivity of the product, thus providing both enantiomers of P(III)‐stereogenic compounds with a single (Rc, Sp)‐Clarke Mn(I) complex catalyst. In this work, we
Bin Wan, Syuzanna R. Harutyunyan
wiley   +1 more source

Elucidating Ligand‐Dependent Selectivities in Pd‐Catalyzed C–H Activations

Angewandte Chemie, EarlyView.
Strategies to understand ligand effects on regioselectivities of C–H activation processes were investigated using an alkynylation of thiophenes as a model system. The results shed light on the role of dispersion models for the correct prediction of reaction outcomes and propose new roles for the solvent and silver additive.
Fritz Deufel, Monika Ravi, Manuel van Gemmeren   +2 more
wiley   +2 more sources

Photocatalytic Enantioselective Radical Cascade Multicomponent Minisci Reaction of β‐Carbolines Using Diazo Compounds as Radical Precursors

Advanced Science
Here, a photocatalytic asymmetric multicomponent cascade Minisci reaction of β‐carbolines with enamides and diazo compounds is reported, enabling an effective enantioselective radical C─H functionalization of β‐carbolines with high yields and ...
Yi‐Jie Gu, Mu‐Peng Luo, Hua Yuan, Guo‐Kai Liu, Shou‐Guo Wang   +4 more
doaj   +1 more source

Enantioselective synthesis of (+)-petromyroxol, enabled by rhodium-catalyzed denitrogenation and rearrangement of a 1-sulfonyl-1,2,3-triazole [PDF]

, 2015
Petromyroxol is a non-racemic mixture of enantiomeric oxylipids isolated from water conditioned with larval sea lamprey. The (+)-antipode exhibits interesting biological properties but only 1 mg was isolated from >100000 L of water.
Boyer, Alistair
core   +2 more sources

Development of a Copper‐Free Click Reaction for Asymmetric Rh Diene Catalysis Under Confinement

Advanced Synthesis &Catalysis, EarlyView.
A copper‐free amino–yne click reaction enables the selective functionalization of chiral diene ligands with both soluble and immobilized amines. Substituent‐controlled stereoselectivity affords (E)‐ and (Z)‐enaminone ligands, which are converted into Rh complexes for asymmetric catalysis under homogeneous and heterogeneous conditions.
Manuel Kirchhof, Sanja Krause, Liam Rautenbach, Jakoba Wacker, Ann‐Katrin Beurer, Hoang‐Huy Nguyen, Wolfgang Frey, Yvonne Traa, Deven P. Estes, Anna Zens, Sabine Laschat   +10 more
wiley   +1 more source

Fluorescence Visualization of Helix Inversion in Biomimic Polymeric Foldamer

Angewandte Chemie, EarlyView.
A facile, rapid, and economical method is provided to directly visualize the solvent‐driven helix inversion in a water‐soluble foldamer using a tetraphenylethene‐functionalized hemicyanine dye based on the emission color change from yellow to red. The dyes are first restricted in the low‐polarity groove but then docked on the foldamer surface with the ...
Yuan Qiu, Zonghang Liu, Chenchen Sun, Xilong Wei, Ryan T. K. Kwok, Yonggui Liao, Jianwei Sun, Jacky W. Y. Lam, Zijie Qiu, Xiaolin Xie, Ben Zhong Tang   +10 more
wiley   +2 more sources

Nickel(II)/BINOL-catalyzed enantioselective C–H activation via desymmetrization and kinetic resolution

Nature Communications
The field of nickel catalysis has witnessed remarkable growth in recent years. However, the use of nickel catalysts in enantioselective C–H activation remains a daunting challenge because of their variable oxidation states, intricate coordination ...
Qi-Jun Yao, Fan-Rui Huang, Jia-Hao Chen, Bing-Feng Shi   +3 more
doaj   +1 more source

Asymmetric Synthesis of Atropisomeric Amines via Transaminase‐Catalyzed Dynamic Kinetic Resolution

Advanced Synthesis &Catalysis, EarlyView.
A dynamic kinetic resolution approach is developed for the atroposelective synthesis of heterobiaryl primary amines. Using transaminases and leveraging Lewis acid‐base interactions to induce racemization, a variety of axially chiral primary amines are produced in high yields and enantioselectivities.
Juan M. Coto‐Cid, Patricia Rodríguez‐Salamanca, Christian M. Heckmann, Caroline E. Paul, Joaquín López‐Serrano, Rosario Fernández, José M. Lassaletta, Valentín Hornillos, Gonzalo de Gonzalo   +8 more
wiley   +1 more source